Locally advanced cervical cancer: A study of 5-year outcomes

Chopra, Supriya; Gupta, Monisha; Mathew, Ashwathy Susan; Mahantshetty, Umesh; Gurram, Lavanya; Gupta, Sudeep; Ghosh, Jaya; Thakur, Meenakshi; Deodhar, Kedar; Menon, Santosh; Rekhi, Bharat; Bajpai, Jyoti; Gulia, Seema; Maheshwari, Amita; Kerkar, Rajendra; Shylasree, TS; Shrivastava, SK

doi:10.4103/ijc.ijc_428_17

Cited by 53 publications

(39 citation statements)

References 9 publications

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“…The current therapy for CC mainly includes surgical treatment, cytotoxic chemotherapy, and radiotherapy. Despite advances in these traditional and newly emerging therapeutic modalities for CC, the 5-year disease-free survival (DFS) rates for advanced staged CC patients are only 45% [6]. Hence, it is crucial to investigate and identify the molecular aberrations in CC so as to develop more effective therapeutic strategies.…”

Section: Introductionmentioning

confidence: 99%

Identification of Core Prognosis-Related Candidate Genes in Cervical Cancer via Integrated Bioinformatical Analysis

Wei

Shi

Wang

2020

BioMed Research International

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Purposes. Cervical cancer (CC) is one of the highest frequently occurred malignant gynecological tumors with high rates of morbidity and mortality. Here, we aimed to identify significant genes associated with poor outcome. Materials and methods. Differentially expressed genes (DEGs) between CC tissues and normal cervical tissues were picked out by GEO2R tool and Venn diagram software. Database for Annotation, Visualization and Integrated Discovery (DAVID) was performed to analyze gene ontology (GO) and Kyoto Encyclopedia of Gene and Genome (KEGG) pathway. The protein-protein interactions (PPIs) of these DEGs were visualized by Cytoscape with Search Tool for the Retrieval of Interacting Genes (STRING). Afterwards, Kaplan-Meier analysis was applied to analyze the overall survival among these genes. The Gene Expression Profiling Interactive Analysis (GEPIA) was applied for further validation of the expression level of these genes. Results. The mRNA expression profile datasets of GSE63514, GSE27678, and GSE6791 were downloaded from the Gene Expression Omnibus database (GEO). In total, 76 CC tissues and 35 normal tissues were collected in the three profile datasets. There were totally 73 consistently expressed genes in the three datasets, including 65 up-regulated genes and 8 down-regulated genes. Of PPI network analyzed by Molecular Complex Detection (MCODE) plug-in, all 65 up-regulated genes and 4 down-regulated genes were selected. The results of the Kaplan-Meier survival analysis showed that 3 of the 65 up-regulated genes had a significantly worse prognosis, while 3 of the 4 down-regulated genes had a significantly better outcome. For validation in GEPIA, 4 of 6 genes (PLOD2, ANLN, AURKA, and AR) were confirmed to be significantly deregulated in CC tissues compared to normal tissues. Conclusion. We have identified three up-regulated (PLOD2, ANLN, and AURKA) and a down-regulated DEGs (AR) with poor prognosis in CC on the basis of integrated bioinformatical methods, which could be regarded as potential therapeutic targets for CC patients.

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Section: Introductionmentioning

confidence: 99%

Identification of Core Prognosis-Related Candidate Genes in Cervical Cancer via Integrated Bioinformatical Analysis

Wei

Shi

Wang

2020

BioMed Research International

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“…Optimal chemoradiation and brachytherapy (BT) in locally advanced cervical cancer (LACC) are associated with 5-year survival rates of 75% and 55% in those with stage IB2 to IIB and IIIB disease, respectively, in clinical trials and tertiary care centers in India. 5-8 Therefore, the National Cancer Grid of India and Indian Council of Medical Research recommend that chemoradiation and BT be the standard of care for LACC. 9,10…”

Section: Introductionmentioning

confidence: 99%

External Radiation and Brachytherapy Resource Deficit for Cervical Cancer in India: Call to Action for Treatment of All

Chopra

Shukla

Budukh

et al. 2019

JGO

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“…Chopra et al . observed that the patients aged over 70 years had a significantly poor DFS at 5 years; however, did not have any effect on survival [ 30 ]. In our study, we have found better survival rates in patients older than 62 years.…”

Section: Discussionmentioning

confidence: 99%

The analysis of the long-term outcomes in elderly women treated for locally advanced cervical cancer

Koper

Dziobek²,

Makarewicz³

et al. 2018

jcb

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PurposeLocally advanced cervical cancer (LACC) should be treated with a combination of external irradiation and brachytherapy with concurrent chemotherapy. However, as cervical carcinoma cells can disperse by way of the lymphatic system to either pelvic or para-aortic nodes, planning the extent of radiation requires precise information about the spread of the disease to the lymph nodes, especially to the para-aortic area.Material and methodsAll of the 75 women included in our study underwent chemoradiotherapy, which started with brachytherapy. Out of them, 54 have undergone radical hysterectomy with lymphadenectomy followed by chemoradiation. We have retrospectively analyzed the 5-year overall survival (OS) rates relative to the lymph node involvement, the type of lymphadenectomy performed (pelvic, para-aortic, or both), the size of the tumor (> or < 4 cm), the histological type, grading, and the age of patients.ResultsWe observed significant differences in the OS rates relative to the age of the patients with LACC. We noted significant differences in the OS rates related to para-aortic lymphadenectomy and presence of lymph node metastases.ConclusionsPara-aortic lymphadenectomy seems to have a positive influence on long-term outcomes in the LACC patients, and elderly patients may benefit more from applied therapy.

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Locally advanced cervical cancer: A study of 5-year outcomes

Abstract: Five-year DFS of 62% and 45% of Stage II and III patients treated under routine care represents comparable stage-matched results to the rest of the world, respectively.

Cited by 53 publications

References 9 publications

Identification of Core Prognosis-Related Candidate Genes in Cervical Cancer via Integrated Bioinformatical Analysis

Identification of Core Prognosis-Related Candidate Genes in Cervical Cancer via Integrated Bioinformatical Analysis

External Radiation and Brachytherapy Resource Deficit for Cervical Cancer in India: Call to Action for Treatment of All

The analysis of the long-term outcomes in elderly women treated for locally advanced cervical cancer

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