Locally advanced leiomyosarcoma of the spleen. A case report and review of the literature

Piovanello, P; Viola, Vincenzo; Costa, Giampaolo; Carletti, Massimiliano; Cecera, Andrea; Turchetta, Fabrizio; Iudicone, R; Catalano, Giuseppe; Santucci, Antonello; Recchia, Franco M.; Fiorillo, Loredana; Menichella, Maria Antonella; Baiano, G

doi:10.1186/1477-7819-5-135

Cited by 9 publications

(5 citation statements)

References 5 publications

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“…Splenic sarcomas are the rarest primary tumors arising in the spleen with only three cases of leiomyosarcoma reported so far [8][9][10]. Two of these were in young women (49 and 54 years old) while the third was described in an 87 year old male patient.…”

Section: Discussionmentioning

confidence: 99%

Primary splenic leiomyosarcoma – case report and literature review

2022

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Primary tumors of the spleen are rarely encountered in clinical practice and their diagnosis often requires invasive procedures (splenectomy). Leiomyosarcomas are rare tumors originating from smooth muscle cells or their precursor mesenchymal cells and as such can arise in any organs, most typically abdominal ones. Only a few cases of leiomyosarcomas of the spleen have been described in literature. We present the case of a 69 year-old, a previously healthy patient, with non-specific symptoms, diagnosed on CT scan with multiple splenic, hepatic and bone tumors. Biopsy from one of the liver tumors revealed the diagnosis of leiomyosarcoma. Due to characteristic aspects on contrast-enhanced ultrasonography and CT scan we concluded that the primary tumor was located in the spleen, while the others represented metastases.

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Section: Discussionmentioning

confidence: 99%

Primary splenic leiomyosarcoma – case report and literature review

2022

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“…LMSs are rare malignant tumors of smooth muscle origin generally found in the uterus, gastrointestinal tract, and retroperitoneum. 1 Primary soft tissue tumors arising from blood vessels are extremely rare and account for <1% of all malignancies. 2 Among them, vascular LMSs only represent 2% of cases and will involve the veins roughly five times more frequently than the arteries.…”

Section: Discussionmentioning

confidence: 99%

A case of leiomyosarcoma of the common femoral artery

Nguyen

León

Pacanowski

et al. 2021

Journal of Vascular Surgery Cases, Innovations and Techniques

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…Most reports about this neoplasm focus on its occurrence in humans (Daudia et al, 2001;Piovanello et al, 2007;Patrono et al, 2014). Giant leiomyosarcoma has been reported in humans in different tissues, such as kidney (Öziş, et al, 2014), uterus (Senol et al, 2016), subcutaneous tissues (Kumar et al, 2016), and rectum (Anzai, 2017).…”

Section: Discussionmentioning

confidence: 99%

Occurrence of splenic leiomyosarcoma in dog: anatomopathological findings

et al. 2017

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Leiomyosarcoma is a malignant neoplasm with origin in smooth muscles. It can originate in the vessel wall and interstitium of the spleen smooth muscle, which is considered rare. The objective of this study was to describe clinical and anatomopathological findings of a splenic leiomyosarcoma in an eight-year-old bitch of the Fila breed. This splenic leiomyosarcoma weighed 9.2 kg, and had 30×27×14 cm in dimension, rounded shape, irregular outline, reddish color alternating with pale areas, friable and hemorrhagic tissues, and necrotic center. After conventional histopathological examination, the suspected diagnosis (leiomyosarcoma) was confirmed by histochemical analysis using Masson's trichrome staining (which showed the reactivity of the muscle tissue) and by immunohistochemical analysis, showed positivity for smooth muscle actin, vimentin, and desmin. This study emphasizes the importance of associating histopathological evaluation with histochemical and immunohistochemical techniques for a diagnosis of this neoplasm. The occurrence of leiomyosarcoma reported here denotes the importance of considering it for a differential diagnosis in cases of splenic tumors.

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Locally advanced leiomyosarcoma of the spleen. A case report and review of the literature

Abstract: Background: Leiomyosarcomas are rare tumours, predominantly localized in the stomach, small intestine and retroperitoneum. Only one case of primary leiomyosarcoma of the spleen is described in human beings in literature.

Cited by 9 publications

References 5 publications

Primary splenic leiomyosarcoma – case report and literature review

Primary splenic leiomyosarcoma – case report and literature review

A case of leiomyosarcoma of the common femoral artery

Occurrence of splenic leiomyosarcoma in dog: anatomopathological findings

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