Locally advanced lymphoepithelial carcinoma of the larynx/hypopharynx: A case report

Clinical outcomes of non‐nasopharyngeal lymphoepithelial carcinoma treated with a combined modality approach: A single‐institution study

“…11 A number of studies targeting specific locations of LEC (such as lung, salivary gland, cervix, and larynx/hypopharynx) have reported similar results, advocating surgery as the primary modality. 7,[12][13][14][15] However, data from our study identified both surgery and radiotherapy as independent prognostic factors for OS and PFS. And the sub-group analysis of treatment modalities on outcomes of pulmonary and salivary LEC showed that radiotherapy significantly improves OS in comparison with the no radiotherapy group for salivary LEC, while surgery significantly improves OS for pulmonary LEC.…”

“…Guidelines from the NCCN recommend chemoradiotherapy combined with induction chemotherapy or adjuvant chemotherapy as the primary treatment for advanced NPC 4 . Further reports have confirmed that chemotherapy is also effective for pulmonary LEC 15 . The majority of non‐chemotherapy cases included in the present study were early stage with good prognosis, and therefore, the cohort failed to reflect the survival benefits of chemotherapy.…”

“…4 Further reports have confirmed that chemotherapy is also effective for pulmonary LEC. 15 The majority of non‐chemotherapy cases included in the present study were early stage with good prognosis, and therefore, the cohort failed to reflect the survival benefits of chemotherapy. Thus, the efficacy of chemotherapy for NNPLEC and potential optimal regimens require further investigation.…”

“…A retrospective cohort study using the Surveillance, Epidemiology, and End Results (SEER) database analyzed 1,184 patients with nasopharyngeal LEC and 922 patients with NNPLEC, which concluded that radiotherapy could be recommended for nasopharyngeal LEC due to its significant survival benefit while surgery should remain the primary treatment strategy for resectable non‐nasopharyngeal LEC 11 . A number of studies targeting specific locations of LEC (such as lung, salivary gland, cervix, and larynx/hypopharynx) have reported similar results, advocating surgery as the primary modality 7,12‐15 . However, data from our study identified both surgery and radiotherapy as independent prognostic factors for OS and PFS.…”

Lymphepithelial carcinoma - a rare tumor of the larynx. Case Report

“…Radiotherapy protocols vary according to stage of the tumor, usually with the 70 Gy (2.0 Gy/fraction) per 7 weeks and for the site of suspected subclinical spread: 44–50 Gy (2.0 Gy/fraction) to 54–63 Gy (1.6–1.8 Gy/fraction). This protocol is suggested in NCCN guidelines (2022) in the treatment of advanced head and neck cancer ( 3 , 5 ).…”