Locally advanced paranasal sinus carcinoma: A study of 30 patients

Perri, Francesco; Addeo, Raffaele; Conson, Manuel; Faiella, A.; Scarpati, Giuseppina Della Vittoria; Torre, Gabriella Della; Biase, Angela Di; Romanelli, P.; Buonerba, Carlo; Lorenzo, Giuseppe Di; Daponte, Antonio; Caponigro, Francesco; Pisconti, Salvatore; Pacelli, Roberto; Ravo, Vincenzo; Muto, Paolo; Solla, Raffaele

doi:10.3892/ol.2017.5598

Cited by 11 publications

(6 citation statements)

References 34 publications

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“…[ 11 12 ] Due to delayed presentation of these tumours, it becomes extremely difficult to determine the exact site of origin because of extensive involvement of surrounding structures. [ 13 14 ] Unlike squamous cell carcinoma of other sites in head-and-neck region, lymph node metastasis in SNM is not commonly seen, with incidence ranging from 3.3% to 26%. [ 1 ] The most common histologies are squamous cell carcinoma followed by adenocarcinoma and adenoid cystic carcinoma etc.…”

Section: Introductionmentioning

confidence: 99%

Outcomes of management of sinonasal malignancies at a dedicated cancer institution: A retrospective study

Dhanani

Faisal

Shahid

et al. 2021

Ann Maxillofac Surg

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Introduction: Sinonasal malignancies (SNMs) are a rare and heterogeneous group of cancers with an incidence of 3%–5% of all head-and-neck tumours. The aim of the present study was to identify the characteristic features of SNMs and to analyze the treatment outcomes and the prognostic factors affecting it. Materials and Methods: A retrospective review of patients with SNM treated at a dedicated cancer center of Pakistan between 2004 and 2018 was carried out. All patients with histologically proven diagnosis of malignancy arising from nasal cavity or paranasal sinuses and being treated with curative intent were included. The medical records of 184 cases were utilized for final analysis. Chi-square test was applied to identify significant differences. Five-year disease-specific survival (DSS) was calculated using Kaplan–Meier curve via log-rank test and comparison was made between squamous and nonsquamous histologies. P ≤0.05 was considered statistically significant. Results: Squamous cell carcinoma was the most common histopathology ( n = 62, 33.7%). 130 (70.7%) patients presented with stage IV disease. Nodal metastasis was seen in 24 (13%) patients. Treatment failure was seen in 96 (52.2%) patients and was significantly associated with tumour size and the overall stage. DSS of patients with squamous cell carcinoma was 29% as compared to 52% for patients with nonsquamous histologies ( P = 0.001). Discussion: SNM is a diverse group of cancers presenting in late stages. A higher rate of treatment failure associated significantly with stage of the disease was identified in our study.

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Section: Introductionmentioning

confidence: 99%

Outcomes of management of sinonasal malignancies at a dedicated cancer institution: A retrospective study

Dhanani

Faisal

Shahid

et al. 2021

Ann Maxillofac Surg

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“…Even if the principle of en bloc resection was followed, the R0 resection rate was still extremely low, only 16.7%. In comparison to our analysis, previous two studies included only locally advanced (T3/T4) sinonasal tumors, and nearly 15% of cases in the rst study underwent endoscopic surgery, with R0 resection rates as high as 60% [28,29]. In this condition, the treatment strategy of surgery and adjuvant radiotherapy obtained good clinical e cacy with the median survival time of 56 months, illustrating the importance of adjuvant radiotherapy and the value of comprehensive treatment.…”

Section: Discussionmentioning

confidence: 66%

Clinical characteristics and long-term outcomes following surgery combined with adjuvant radiotherapy for primary frontal sinus malignancies: A single-center analysis

Wang

Zhang

et al. 2021

Preprint

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Objective This study aimed to determine clinicopathologic characteristics of primary frontal sinus malignancies (FSMs) and provide long-term survival results. Materials and methods A retrospective study of six cases of primary FSMs at our center from 2006 to 2016 was performed. The demographics characteristics, tumor characteristics, treatment modalities and survival outcomes were recorded. Results In this series, the median age was 48 years (30–53 years) and all patients were male. There were five cases with squamous cell carcinoma, and one with osteosarcoma. All cases presented with locally advanced disease without regional lymphatic metastasis, including 5 cases of stage Ⅲ and one of stage Ⅱ. The two most common pathways of tumor invasion were as follows: local tumor broke posteriorly through bone wall and invaded dura mater, followed by frontal lobe; local tumor infiltrated downward through the floor of frontal sinus into ethmoid sinus, thereafter invaded laterally orbit and orbital contents. All patients received surgery followed by postoperative radiotherapy at the total doses of 50Gy to 75.95Gy. Among them, only one patient underwent R0 resection, the rest of patients underwent R1/R2 resection. With a median survival time of 56 months (32 to 76 months), two patients receiving R1/R2 resection developed treatment failure and died within 5 years, including one case with local recurrence, and one with local recurrence thereafter distant metastasis. Conclusion The majority of FSMs presented with peripherally invasive progression lesions, which led to a high ratio of R1/R2 resection. Surgery combined with postoperative radiotherapy might result in satisfactory efficacy.

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“…On univariate analysis, the authors found that stage of the disease was the most significant factor associated with outcome of the disease. 6 Danesh-Sani et al found in their study that males were 62.2% compared to only 37.8% of the female cases. 7 This finding is in concordance with the finding of the present study where we also observed that males were more than females and the male to female ratio was 2:1.…”

Section: Discussionmentioning

confidence: 88%

“…Peril et al studied 30 cases of advanced sinonasal cancer retrospectively. 6 These cases were first operated surgically and then they were given radiotherapy or chemotherapy. They found that 31 month survival rate was 33.3%.…”

Section: Discussionmentioning

confidence: 99%

Clinical study of non epidermoid malignancies of the paranasal sinuses

Rao

Kaur

2019

Int J Otorhinolaryngol Head Neck Surg

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Background: Malignancy of paranasal sinuses post challenging issues not only for surgeons but also for radiologists. Patients also try to avoid and neglect the condition. Hence clinical studies are more pertinent on this issue. Objective was to study clinical picture of non epidermoid malignancies of the paranasal sinuses.Methods: This was a retrospective hospital based study of 30 patients with non epidermoid malignancies of the paranasal sinuses from two hospitals over a period of more than four years. Clinical characteristics were studied. CT scan, diagnostic nasal endoscopy, histopathology was done for all patients. Data was analyzed using proportions. Results: Majority affected were males. The male to female ratio was 2:1. Maximum cases were found in the age group of 51-60 years and all of them were males. Left side was most commonly affected. The most common presenting feature was nasal obstruction in 50% of the cases. Nasal endoscopy findings has shown that there were five cases each of pinkish red polypoid mass, pinkish grey fleshy mass, pinkish red proliferative mass, pink fleshy mass, purulent discharge and fleshy pinkish red mass. Heterogeneous soft tissue density was the most common CT scan finding. Non Hodgkins lymphoma was more common. Half of the cases were managed by maxillectomy and half of the cases were managed by radiotherapy. There was no recurrence of the tumor after 6-9 months of follow up.Conclusions: Males are more commonly affected than females. Appropriate management of cases prevents recurrence of the tumors.

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Locally advanced paranasal sinus carcinoma: A study of 30 patients

Abstract: Abstract. Sinonasal carcinomas (SNcs) are rare neoplasms arising from the paranasal sinuses and nasal cavity. Although

Cited by 11 publications

References 34 publications

Outcomes of management of sinonasal malignancies at a dedicated cancer institution: A retrospective study

Outcomes of management of sinonasal malignancies at a dedicated cancer institution: A retrospective study

Clinical characteristics and long-term outcomes following surgery combined with adjuvant radiotherapy for primary frontal sinus malignancies: A single-center analysis

Clinical study of non epidermoid malignancies of the paranasal sinuses

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