Locally aggressive central odontogenic fibroma associated to an inflammatory cyst: a clinical, histological and immunohistochemical study

Abstract

The case describes a 38-year-old woman presenting a multilocular radiolucency affecting the entire right half of the lower jaw, with an unerupted third molar displaced to the region of the coronoid process. The histological study showed the presence of fibroblasts, focally with pleomorphic nuclei, dense collagen and an odontogenic epithelium with dystrophic calcifications. A cyst with an important inflammatory infiltrate was, moreover, observed.

Odontogenic fibroma — a case report

“…OF consists of fibroblasts located in a myxoid matrix with collagen fibres [6]. The matrix can also contains epithelial-rich and epithelial-poor areas, as were observed in the present case.…”

“…However, according to the majority of the authors, OF develops more frequently in the mandible and in the area of the posterior teeth [6]. The authors also emphasise that tumour growth is slow and initially asymptomatic.…”

“…According to Cercadillo-Ibarguren et al, there are 68 cases of odontogenic fibroma reported in literature and Calvo et al mention 22 cases [6,8]. The peripheral type of this tumour is extremely rare.…”

“…Cercadillo-Ibarguren et al described a case involving a large CEF covering the ramus, angle of the mandible and the distal section of the mandibular body. This lesion coexisted with the presence of an inflammatory cyst [6]. Calvo et al presented the case of a 61-year-old patient who came to a hospital with symptoms of an abscess in the anterior part of the maxilla [8].…”

“…OF develops within the mandible six times more frequently than within the maxilla. Within the mandible it usually develops in the posterior area, whereas in the case of the maxilla it occurs in the area of the front teeth [6].…”