Locally Controlled Release of Methotrexate and Alendronate by Thermo-Sensitive Hydrogels for Synergistic Inhibition of Osteosarcoma Progression

Shan, Hongli; Li, Ké; Zhao, Duoyi; Chi, Changliang; Tan, Qinyuan; Wang, Xiaoqing; Yu, Jinhai; Piao, Meihua

doi:10.3389/fphar.2020.00573

Cited by 16 publications

(10 citation statements)

References 38 publications

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“…The aforementioned strategy has been followed, wherein injectable thermo-sensitive poly (L-valine) hydrogel containing methotrexate and alendronate was employed in osteosarcoma progression, which managed sustainable release at the tumor site. More precisely, this developed system has reduced bone destruction and lung metastasis due to osteosarcoma (reduction in bone density, hence weakness) [ 108 , 109 ].…”

Section: Strategies In Bone Targetingmentioning

confidence: 99%

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Lipid-Based Nano-Sized Cargos as a Promising Strategy in Bone Complications: A Review

et al. 2022

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Bone metastasis has been considered the fatal phase of cancers, which remains incurable and to be a challenge due to the non-availability of the ideal treatment strategy. Unlike bone cancer, bone metastasis involves the spreading of the tumor cells to the bones from different origins. Bone metastasis generally originates from breast and prostate cancers. The possibility of bone metastasis is highly attributable to its physiological milieu susceptible to tumor growth. The treatment of bone-related diseases has multiple complications, including bone breakage, reduced quality of life, spinal cord or nerve compression, and pain. However, anticancer active agents have failed to maintain desired therapeutic concentrations at the target site; hence, uptake of the drug takes place at a non-target site responsible for the toxicity at the cellular level. Interestingly, lipid-based drug delivery systems have become the center of interest for researchers, thanks to their biocompatible and bio-mimetic nature. These systems possess a great potential to improve precise bone targeting without affecting healthy tissues. The lipid nano-sized systems are not only limited to delivering active agents but also genes/peptide sequences/siRNA, bisphosphonates, etc. Additionally, lipid coating of inorganic nanomaterials such as calcium phosphate is an effective approach against uncontrollable rapid precipitation resulting in reduced colloidal stability and dispersity. This review summarizes the numerous aspects, including development, design, possible applications, challenges, and future perspective of lipid nano-transporters, namely liposomes, exosomes, solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), and lipid nanoparticulate gels to treat bone metastasis and induce bone regeneration. Additionally, the economic suitability of these systems has been discussed and different alternatives have been discussed. All in all, through this review we will try to understand how far nanomedicine is from clinical and industrial applications in bone metastasis.

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Section: Strategies In Bone Targetingmentioning

confidence: 99%

“…However, some complications in preparation and applications are also associated with the hydrogels. Therefore, the specific site of application and its clinical effectiveness still need to be explored [ 109 ].…”

Section: Strategies In Bone Targetingmentioning

confidence: 99%

Lipid-Based Nano-Sized Cargos as a Promising Strategy in Bone Complications: A Review

et al. 2022

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“…Hence, several scientists developed MTX loaded hydrogel to improve solubility and lower the side effects and treat cancer [ 61 , 130 ]. For example, a novel MTX and alendronate co-loaded mPEG45–PLV19 containing thermosensitive hydrogel was developed by scientists, demonstrating synergistic inhibition osteosarcoma with sustained release of drugs [ 131 ]. In another study, investigators developed in situ MTX loaded gelatin and poly(vinyl) alcohol (Gel/PVA) hydrogel and used to treat colorectal disorders [ 132 ].…”

Section: Methotrexate-loaded Hydrogels For Cancer Therapymentioning

confidence: 99%

New Horizons in Hydrogels for Methotrexate Delivery

Dehshahri

Kumar

Madamsetty

et al. 2020

Gels

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Since its first clinical application, methotrexate (MTX) has been widely used for the treatment of human diseases. Despite great advantages, some properties such as poor absorption, short plasma half-life and unpredictable bioavailability have led researchers to seek novel delivery systems to improve its characteristics for parenteral and oral administration. Recently, great attention has been directed to hydrogels for the preparation of MTX formulations. This review describes the potential of hydrogels for the formulation of MTX to treat cancer, rheumatoid arthritis, psoriasis and central nervous system diseases. We will delineate the state-of-the-art and promising potential of hydrogels for systemic MTX delivery as well as transdermal delivery of the drug-using hydrogel-based formulations.

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“…mPEG 45 -PLV 19 (5.0 wt%) was stirred slowly and thoroughly at 4 • C overnight, and OXA (5.0 mg/mL) (Feather et al, 2018) and ALN (10.0 mg/mL) (Shan et al, 2020) were added to the polymer solution and mixed thoroughly (4 • C) to keep injectable. The sol state is used for tumor suppression experiments.…”

Section: Thermo-sensitive Hydrogel Loaded With Drugsmentioning

confidence: 99%

Thermogel Delivers Oxaliplatin and Alendronate in situ for Synergistic Osteosarcoma Therapy

Sun

et al. 2020

Front. Bioeng. Biotechnol.

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The therapeutic effect of osteosarcoma (OS) has not made extraordinary progress in the past few decades. Oxaliplatin (OXA) is a widely used clinical anti-tumor drug. Recent studies have shown that OXA can trigger anti-tumor immunity by inducing immunogenic death (ICD). Alendronate (ALN) has been used to threaten the skeletal system tumors because of the unique bone affinity and the ability to inhibit bone destruction. In this study, we co-loaded OXA and ALN on mPEG45-PLV19 thermo-sensitive hydrogel to perform in situ treatment on the mouse OS model. Slowly released OXA can induce immunogenic death of tumor cells. At the same time, thermo-sensitive hydrogels can induce the accumulation of cytotoxic T lymphocytes. Besides, ALN could synergistically diminish tumors and prevent bone destruction. This system could synergistically inhibit the progression of OS and lung metastasis and has no toxicity to various organs throughout the body.

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Locally Controlled Release of Methotrexate and Alendronate by Thermo-Sensitive Hydrogels for Synergistic Inhibition of Osteosarcoma Progression

Cited by 16 publications

References 38 publications

Lipid-Based Nano-Sized Cargos as a Promising Strategy in Bone Complications: A Review

Lipid-Based Nano-Sized Cargos as a Promising Strategy in Bone Complications: A Review

New Horizons in Hydrogels for Methotrexate Delivery

Thermogel Delivers Oxaliplatin and Alendronate in situ for Synergistic Osteosarcoma Therapy

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