Locally Delivered Doxycycline as an Adjunctive Therapy to Scaling and Root Planing in the Treatment of Smokers: A 2‐Year Follow‐Up

Machion, Luciana; Andia, Denise Carleto; Lecio, Giovana; Nociti, Francisco Humberto; Casati, Márcio Zaffalon; Sallum, Antônio Wilson; Sallum, Enílson Antônio

doi:10.1902/jop.2006.050087

Cited by 53 publications

(61 citation statements)

References 17 publications

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“…Clinically, although the use of systemic and local antimicrobials, in combination with scaling and root planning, produces greater benefits than mechanical periodontal therapy alone (4,5), recurrent/ refractory disease still occurs after all types of periodontal treatment. There is therefore an interest in developing therapeutic approaches for periodontitis that are more efficient.…”

Section: {‖mentioning

confidence: 99%

Exogenous Administration of 15d-PGJ2–Loaded Nanocapsules Inhibits Bone Resorption in a Mouse Periodontitis Model

Napimoga

Silva

Carregaro

et al. 2012

The Journal of Immunology

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The 15-deoxy-Δ12,14-PG J2 (15d-PGJ2) has demonstrated excellent anti-inflammatory results in different experimental models. It can be used with a polymeric nanostructure system for modified drug release, which can change the therapeutic properties of the active principle, leading to increased stability and slower/prolonged release. The aim of the current study was to test a nanotechnological formulation as a carrier for 15d-PGJ2, and to investigate the immunomodulatory effects of this formulation in a mouse periodontitis model. Poly (D,L-lactide-coglycolide) nanocapsules (NC) were used to encapsulate 15d-PGJ2. BALB/c mice were infected on days 0, 2, and 4 with Aggregatibacter actinomycetemcomitans and divided into groups (n = 5) that were treated daily during 15 d with 1, 3, or 10 μg/kg 15d-PGJ2-NC. The animals were sacrificed, the submandibular lymph nodes were removed for FACS analysis, and the jaws were analyzed for bone resorption by morphometry. Immunoinflammatory markers in the gingival tissue were analyzed by reverse transcriptase-quantitative PCR, Western blotting, or ELISA. Infected animals treated with the 15d-PGJ2-NC presented lower bone resorption than infected animals without treatment (p < 0.05). Furthermore, infected animals treated with 10 μg/kg 15d-PGJ2-NC had a reduction of CD4+CD25+FOXP3+ cells and CD4/CD8 ratio in the submandibular lymph node (p < 0.05). Moreover, CD55 was upregulated, whereas RANKL was downregulated in the gingival tissue of the 10 μg/kg treated group (p < 0.05). Several proinflammatory cytokines were decreased in the group treated with 10 μg/kg 15d-PGJ2-NC, and high amounts of 15d-PGJ2 were observed in the gingiva. In conclusion, the 15d-PGJ2-NC formulation presented immunomodulatory effects, decreasing bone resorption and inflammatory responses in a periodontitis mouse model.

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Section: {‖mentioning

confidence: 99%

Exogenous Administration of 15d-PGJ2–Loaded Nanocapsules Inhibits Bone Resorption in a Mouse Periodontitis Model

Napimoga

Silva

Carregaro

et al. 2012

The Journal of Immunology

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“…53 Recent studies have suggested that the adjunct use of local and systemic antimicrobial therapy may improve the clinical results obtained with scaling/ root planing 54 and guided tissue regeneration in smokers. 55 Machion et al 56,57 showed that the association of scaling and root planing to local 10% doxycycline in the treatment of smokers with chronic periodontitis may lead to better clinical results than mechanical therapy alone.…”

Section: Periodontal Treatment In Smokersmentioning

confidence: 99%

Smoking and periodontal tissues: a review

et al. 2012

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The impact of smoking on general health has been widely studied and is directly related to several important medical problems including cancer, low birth weight, and pulmonary and cardiovascular disease. In the past 25 years, there has also been an increasing awareness of the role of cigarette consumption in oral health problems such as periodontal disease. Smoking is considered the major risk factor in the prevalence, extent and severity of periodontal diseases. This article will discuss the available evidence and provide the reader with an overview of the impact of smoking and its cessation on the pathogenesis and treatment of periodontal diseases.

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“…These studies have found smokers respond less favorably to periodontal therapy than nonsmokers, regardless of therapy received. However, use of systemic 97,98 and local [99][100][101] antibiotics as adjuncts to SRP may provide an additional benefit in the treatment response of smokers.…”

Section: Smoking and Periodontal Diseasementioning

confidence: 99%

Treating chronic periodontitis: current status, challenges, and future directions

Shaddox¹

2010

CCIDE

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Periodontitis affects roughly one-third of the US population. A timely diagnosis of chronic periodontitis at its earliest stage is essential to avoid more challenging severe stages of the disease. Most cases of slight and moderate chronic periodontitis can be successfully managed by mechanical removal and/or reduction of subgingival bacterial biofilms and calculus. However, any factor that affects either the local environment or the host response may contribute to progression of the disease and a poor treatment response. Thus, it is essential that clinicians are aware of etiologic and risk factors associated with disease development and progression in order to plan and execute a successful treatment. This paper reviews a variety of risk factors, both local and systemic, that can impact the successful treatment of chronic periodontitis.

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Locally Delivered Doxycycline as an Adjunctive Therapy to Scaling and Root Planing in the Treatment of Smokers: A 2‐Year Follow‐Up

Abstract: The use of locally delivered doxycycline may constitute an important adjunct for the active and supportive treatments of severe periodontal disease in smokers.

Cited by 53 publications

References 17 publications

Exogenous Administration of 15d-PGJ2–Loaded Nanocapsules Inhibits Bone Resorption in a Mouse Periodontitis Model

Exogenous Administration of 15d-PGJ2–Loaded Nanocapsules Inhibits Bone Resorption in a Mouse Periodontitis Model

Smoking and periodontal tissues: a review

Treating chronic periodontitis: current status, challenges, and future directions

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