Location and stability of the preferred retinal locus in native Persian‐speaking patients with age‐related macular degeneration

Farzaneh, Abdollah; Riazi, Abbas; Khabazkhoob, Mehdi; Doostdar, Asgar; Farzaneh, Mehrnaz; Falavarjani, Khalil Ghasemi

doi:10.1111/cxo.13132

Cited by 7 publications

(11 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This difference is either due to the better performance of the central, left, superior, and inferior areas than the right visual field or because of the reading difficulty in right-field PRL. The retinal sensitivity was higher in the right visual field than in other areas, 36 but the RA in the right visual field was significantly worse. It seems that individuals with macular degeneration try to place the scotoma in an area of the visual field that improves their visual function.…”

Section: Discussionmentioning

confidence: 79%

“…The image processing technique was described in another paper. 36 Briefly, the images taken with the Microperimeter and OCT instruments and the ETDRS grid were processed using AutoCAD 2018 software version 28.0 (Autodesk Inc., US), ImageJ, and Photoshop CC 2019 software version 20.0 (Adobe Inc., US) to determine precisely the PRL position [ Figure 1 ]. The macula is divided into five fields, including central, inferior, superior, nasal, and temporal, using the ETDRS grid (6 × 6 mm).…”

Section: Ethodsmentioning

confidence: 99%

See 1 more Smart Citation

Evaluating Reading Performance in Different Preferred Retinal Loci in Persian-Speaking Patients with Age-Related Macular Degeneration

Farzaneh

Riazi

Falavarjani

et al. 2021

Journal of Current Ophthalmology

View full text Add to dashboard Cite

Purpose:To evaluate reading performance in different preferred retinal loci (PRLs) using a Persian version of a Minnesota Low Vision Reading (MNREAD) chart in Persian-speaking patients with age-related macular degeneration (AMD).Methods:In this cross-sectional study, 35 patients with AMD were assessed. The reading performance was investigated by the MNREAD chart without using low vision aids. The location of PRL was determined monocularly using an MP1 microperimeter (Nidek Technologies, Padua, Italy). The anatomical location of the fovea was determined using optical coherence tomography (OCT). Images were taken with the MP1 microperimeter, and Spectralis HRA-OCT device was processed using graphic software to determine the location of the PRL on the retina.Results:Thirty-five patients (51 eyes) with a mean age of 73.8 ± 7.7 years (range, 54–88 years) were assessed. Mean best corrected distance visual acuity (logMAR) was 0.65 ± 0.35 (range, 0.2–1.3). Mean levels of reading acuity (RA) (P= 0.009) and critical print size (CPS) (P= 0.015) were significantly different in different locations of PRL. Average scores of maximum reading speed (MRS) (P= 0.058) and reading accessibility index (ACC) (P= 0.058) were not statistically significant in different locations of PRL. There was a positive correlation between PRL-fovea distance and RA (P< 0.001,r= 0.591) and CPS (P< 0.001,r= 0.614). Significant negative correlations were observed between PRL-fovea distance and MRS (P< 0.001,r= −0.519) and ACC (P< 0.001,r= −0.545).Conclusions:This study provides evidence for differences in the reading performance of Persian-speaking patients with AMD in different PRL locations. The average scores of all reading indices obtained in the right-field PRL are lower than those in other areas and are highly correlated with the PRL-fovea distance.

show abstract

Section: Discussionmentioning

confidence: 79%

Section: Ethodsmentioning

confidence: 99%

Evaluating Reading Performance in Different Preferred Retinal Loci in Persian-Speaking Patients with Age-Related Macular Degeneration

Farzaneh

Riazi

Falavarjani

et al. 2021

Journal of Current Ophthalmology

View full text Add to dashboard Cite

show abstract

“…We detected no statistically significant relationship between PRL location and fixation stability. Similarly, Farzaneh et al 27 found no significant relationship between PRL location on the retina and fixation stability in native Persian-speaking AMD patients.…”

Section: Discussionmentioning

confidence: 93%

“…Studies have shown that the PRL, which replaces the nonfunctioning fovea in eyes with central scotoma, is less stable as its distance from the fovea increases. 6 , 9 , 10 , 27 The mean PRL-fovea distance in AMD was reported to be 6.69°±7.4° by Erbezci and Oztürk 9 and 6.25°±2.38° by Sahli et al, 19 while Fujita et al 28 reported distances between 5° and 11°. In our study, the mean PRL-fovea distance was 5.15°±3.31° (range, 0.75°-14.2°).…”

Section: Discussionmentioning

confidence: 96%

Fixation Stability and Preferred Retinal Locus in Advanced Age-Related Macular Degeneration

Altınbay¹,

İdil²

2022

tjo

View full text Add to dashboard Cite

Objectives: To evaluate fixation stability and characteristics of the preferred retinal locus (PRL) in patients with advanced age-related macular degeneration (AMD). Materials and Methods: Sixty-three eyes of 63 patients with AMD who presented to the low vision unit were included in this prospective study. Sociodemographic characteristics, eye examination findings, and reading performance results with the Minnesota Low Vision Reading test were evaluated. Microperimetry was used to evaluate fixation stability and PRL characteristics. Results: There was unstable fixation in 68% of the eyes, relative stable fixation in 27%, and stable fixation in 5%. The mean PRL-foveal distance was 5.15°±3.31° (range 0.75°-14.2°). PRL-foveal distance was greater in cases with unstable fixation than cases with stable fixation (p=0.023). Distance of the PRL from the lesion margin was not associated with absolute scotoma size or fixation stability (p=0.315, p=0.095, respectively). PRLs were most frequently located in the nasal quadrant (31%), followed by the superior quadrant (26%) of the retina. There was no significant relationship between PRL location and fixation stability (p=0.088). Fixation stability was significantly associated with reading speed (p=0.003). Conclusion: In advanced AMD, PRL-foveal distance is an important factor in fixation stability. Knowing the factors that affect fixation stability may be important in determining low vision rehabilitation strategies for these patients because of the strong association between fixation stability and reading speed.

show abstract

“…All in all, little is known about the formation of PRLs in people with central vision loss. According to a study by Farzaneh et al (2021), who used a Nidek MP-1 microperimeter and Image J software to evaluate the fixation characteristics plus optical coherence tomography to determine the location of the central fovea in patients with AMD, the participants most frequently placed their PRL in the inferior and left visual field, which would result in a scotoma displacement to the superior and right visual field. Fixation stability was statistically similar in different locations of PRL, but improved with decreasing distance between PRL and fovea.…”

Section: Introductionmentioning

confidence: 99%

Cortical Thickness Related to Compensatory Viewing Strategies in Patients With Macular Degeneration

et al. 2021

View full text Add to dashboard Cite

Retinal diseases like age-related macular degeneration (AMD) or hereditary juvenile macular dystrophies (JMD) lead to a loss of central vision. Many patients compensate for this loss with a pseudo fovea in the intact peripheral retina, the so-called “preferred retinal locus” (PRL). How extensive eccentric viewing associated with central vision loss (CVL) affects brain structures responsible for visual perception and visually guided eye movements remains unknown. CVL results in a reduction of cortical gray matter in the “lesion projection zone” (LPZ) in early visual cortex, but the thickness of primary visual cortex appears to be largely preserved for eccentric-field representations. Here we explore how eccentric viewing strategies are related to cortical thickness (CT) measures in early visual cortex and in brain areas involved in the control of eye movements (frontal eye fields, FEF, supplementary eye fields, SEF, and premotor eye fields, PEF). We determined the projection zones (regions of interest, ROIs) of the PRL and of an equally peripheral area in the opposite hemifield (OppPRL) in early visual cortex (V1 and V2) in 32 patients with MD and 32 age-matched controls (19–84 years) by functional magnetic resonance imaging. Subsequently, we calculated the CT in these ROIs and compared it between PRL and OppPRL as well as between groups. Additionally, we examined the CT of FEF, SEF, and PEF and correlated it with behavioral measures like reading speed and eccentric fixation stability at the PRL. We found a significant difference between PRL and OppPRL projection zones in V1 with increased CT at the PRL, that was more pronounced in the patients, but also visible in the controls. Although the mean CT of the eye fields did not differ significantly between patients and controls, we found a trend to a positive correlation between CT in the right FEF and SEF and fixation stability in the whole patient group and between CT in the right PEF and reading speed in the JMD subgroup. The results indicate a possible association between the compensatory strategies used by patients with CVL and structural brain properties in early visual cortex and cortical eye fields.

show abstract

Location and stability of the preferred retinal locus in native Persian‐speaking patients with age‐related macular degeneration

Cited by 7 publications

References 44 publications

Evaluating Reading Performance in Different Preferred Retinal Loci in Persian-Speaking Patients with Age-Related Macular Degeneration

Evaluating Reading Performance in Different Preferred Retinal Loci in Persian-Speaking Patients with Age-Related Macular Degeneration

Fixation Stability and Preferred Retinal Locus in Advanced Age-Related Macular Degeneration

Cortical Thickness Related to Compensatory Viewing Strategies in Patients With Macular Degeneration

Contact Info

Product

Resources

About