Location of Electric Current Sources with Activation of Experimental Occlusal Interference in the Human Brain by Dipole Tracing Method

Toyoda, Yasuo; Mushimoto, Eiko

doi:10.2186/jjps.48.183

Cited by 6 publications

(2 citation statements)

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“…A study investigating the interaction between mastication and brain blood flow (BBF) with positron-emission tomography revealed that chewing activates widespread regions of the brain 11 . Electroencephalograms also revealed that experimental premature contact affects brain function in healthy volunteers 12 . Together, ideal occlusion would be an essential factor for maintaining favorable brain function.…”

Section: Introductionmentioning

confidence: 97%

Mandibular prognathism attenuates brain blood flow induced by chewing

Kanzaki

Wada

Kumazawa

et al. 2019

Sci Rep

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Mastication is closely related to brain function. Animal experiments have revealed that tooth loss has a negative influence on brain function. Clinical studies also suggest that normal occlusion is an essential factor for favorable brain function. Mandibular prognathism (MP) usually results in occlusal dysfunction. However, the relationship between MP and brain function remains unclear. In the present study, we examined the relationship between MP and brain function by measuring brain blood flow (BBF). Seventeen subjects with normal occlusion (NORM) and 25 patients with MP participated in this study. The number of occlusal contacts were counted. Electromyography of the masseter muscles during clenching was also recorded. BBF was measured with non-invasive functional near-infrared spectroscopy during calculation task and chewing task. The number of the occlusal contacts and masseter muscle activity were lower in MP compared with NORM. The calculation task increased BBF in both groups. The chewing task also increased BBF in the inferior frontal gyrus in both groups, although the increase in MP was smaller than in NORM. We discovered that patients with MP exhibited a smaller increase in BBF at the inferior frontal gyrus during chewing as compared with NORM. As such, MP would negatively affect brain function.

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Section: Introductionmentioning

confidence: 97%

Mandibular prognathism attenuates brain blood flow induced by chewing

Kanzaki

Wada

Kumazawa

et al. 2019

Sci Rep

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“…For example, in humans, occlusal interference induces changes in electroencephalogram recordings accompanied by feelings of discomfort 1,2) . In rats, occlusal interference induces c-fos mRNA expression in the amygdala, piriform cortex, and other brain areas 3) .…”

Section: Introductionmentioning

confidence: 99%

The bite-raised condition enhances the aging process in the dorsal and ventral hippocampus

Kubo¹,

Saitoh

Kogaya³

et al. 2008

Okajimas Folia Anat. Jpn.

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Summary:The bite raised condition decreases the number of neurons and increases the amount of glial fibrillary acidic protein in the hippocampus of aged SAMP8 mice. In the present study, we examined whether these effects differ between the dorsal and ventral hippocampus. In bite-raised SAMP8 mice, the number of neurons was significantly lower in the hippocampal CA1 and dentate gyrus (DG) subfields compared to control mice. In the bite raised condition, the number of neurons was significantly lower in both the dorsal and ventral CA3 subfields, and the number of glial fibrillary acidic proteinlabeled astrocytes was increased in the CA1, CA3, and DG subfields, compared to control mice. These data suggest that in aged SAMP8 mice, the bite-raised condition enhanced aging processes in both the dorsal and ventral hippocampus.

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