Location of the Primary Gustatory Area in Humans and its Properties, Studied by Magnetoencephalography

Kobayakawa, Tatsu

doi:10.1093/chemse/bjh196

Cited by 25 publications

(14 citation statements)

References 18 publications

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“…The first and last sessions in the behavioral chamber consisted of 15-20 minute periods in which animals were habituated to the behavioral chamber in the absence of tastes. During the middle experimental session (depicted in Figure 1A ), rats received a pseudo-randomized sequence of four standard taste stimuli [sweet: 4 mM saccharin (S); salty: 100 mM sodium chloride (N); neutral: distilled water (W); and bitter: 5 mM quinine hydrochloride (Q)] that varied in hedonic value and fell within the range of concentrations typically used by other groups (3-20 mM saccharin, 10-300 mM sodium chloride, and 1-10 mM quinine; for review, see Frank and Brown, 2003; Kobayakawa et al, 2005; Accolla and Carleton, 2008; Geran and Travers, 2009; Rosen et al, 2010; Chen et al, 2011; MacDonald et al, 2012; Li and Lemon, 2015; Sadacca et al, 2016). Taste solutions were delivered directly onto the tongue in ~40 µL aliquots via four polyamide tubes inserted into the IOC, with a separate tube for each solution to prevent the mixing of tastes.…”

Section: Methodsmentioning

confidence: 99%

Interaction of taste and place coding in the hippocampus

Herzog

Pascual

Scott

et al. 2018

Preprint

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An animal’s survival depends on finding food, and the memory of food and contexts are often linked. Given that the hippocampus is required for spatial and contextual memory, it is reasonable to expect related coding of space and food stimuli in hippocampal neurons. However, relatively little is known about how the hippocampus responds to tastes, the most central sensory property of food. In this study, we examined the taste-evoked responses and spatial firing properties of single units in the dorsal CA1 hippocampal region as male rats received a battery of taste stimuli differing in both chemical composition and palatability within a specific spatial context. We identified a subset of hippocampal neurons that responded to tastes, some of which were place cells. These taste and place responses had a distinct interaction: taste-responsive cells tended to have less spatially specific firing fields, and place cells only responded to tastes delivered inside their place field. Like neurons in the amygdala and lateral hypothalamus, hippocampal neurons discriminated between tastes predominantly on the basis of palatability, with taste-selectivity emerging concurrently with palatability-relatedness; these responses did not reflect movement or arousal. However, hippocampal taste responses emerged several hundred msec later than responses in other parts of the taste system, suggesting that the hippocampus does not influence real-time taste decisions, instead associating the hedonic value of tastes with a particular context. This incorporation of taste responses into existing hippocampal maps could be one way that animals use past experience to locate food sources.Significance statementFinding food is essential for animals’ survival, and taste and context memory are often linked. While hippocampal responses to space and contexts have been well characterized, little is known about how the hippocampus responds to tastes. Here, we identified a subset of hippocampal neurons that discriminated between tastes based on palatability. Cells with stronger taste responses typically had weaker spatial responses, and taste responses were confined to place cells’ firing fields. Hippocampal taste responses emerged later than in other parts of the taste system, suggesting that the hippocampus does not influence taste decisions, but rather, associates the hedonic value of tastes consumed within a particular context. This could be one way that animals use past experience to locate food sources.

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Section: Methodsmentioning

confidence: 99%

Interaction of taste and place coding in the hippocampus

Herzog

Pascual

Scott

et al. 2018

Preprint

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“…In the insula, Small D. M. et al (2003) with fMRI and Kobayakawa T. et al (2005) with MEG found indication of the coding of intensity of taste. O'Doherty J.…”

Section: Intensity Coding Absence Of Chemotopymentioning

confidence: 97%

Functional Magnetic Resonance Imaging Study of Taste

Faurion

Kobayakawa

Cerf-Ducastel

2008

The Senses: A Comprehensive Reference

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“…During the middle experimental session (depicted in Fig. 1A), rats received a pseudorandomized sequence of four standard taste stimuli [sweet: 4 mM saccharin (S); salty: 100 mM sodium chloride (N); neutral: distilled water (W); and bitter: 5 mM quinine hydrochloride (Q)] that varied in hedonic value and fell within the range of concentrations typically used in other studies (3-20 mM saccharin, 10 -300 mM sodium chloride, and 1-10 mM quinine; for review, see Frank and Brown, 2003;Kobayakawa et al, 2005;Accolla and Carleton, 2008;Geran and Travers, 2009;Rosen et al, 2010;Chen et al, 2011;MacDonald et al, 2012;Li and Lemon, 2015;Sadacca et al, 2016). Taste solutions were delivered directly onto the tongue in ϳ40 l aliquots via four polyamide tubes inserted into the IOC, with a separate tube for each solution to prevent the mixing of tastes.…”

Section: Passive Taste Administration Paradigmmentioning

confidence: 99%

Interaction of Taste and Place Coding in the Hippocampus

et al. 2019

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An animal's survival depends on finding food and the memory of food and contexts are often linked. Given that the hippocampus is required for spatial and contextual memory, it is reasonable to expect related coding of space and food stimuli in hippocampal neurons. However, relatively little is known about how the hippocampus responds to tastes, the most central sensory property of food. In this study, we examined the taste-evoked responses and spatial firing properties of single units in the dorsal CA1 hippocampal region as male rats received a battery of taste stimuli differing in both chemical composition and palatability within a specific spatial context. We identified a subset of hippocampal neurons that responded to tastes, some of which were place cells. These taste and place responses had a distinct interaction: taste-responsive cells tended to have less spatially specific firing fields and place cells only responded to tastes delivered inside their place field. Like neurons in the amygdala and lateral hypothalamus, hippocampal neurons discriminated between tastes predominantly on the basis of palatability, with taste selectivity emerging concurrently with palatability-relatedness; these responses did not reflect movement or arousal. However, hippocampal taste responses emerged several hundred milliseconds later than responses in other parts of the taste system, suggesting that the hippocampus does not influence real-time taste decisions, instead associating the hedonic value of tastes with a particular context. This incorporation of taste responses into existing hippocampal maps could be one way that animals use past experience to locate food sources.Finding food is essential for animals' survival and taste and context memory are often linked. Although hippocampal responses to space and contexts have been well characterized, little is known about how the hippocampus responds to tastes. Here, we identified a subset of hippocampal neurons that discriminated between tastes based on palatability. Cells with stronger taste responses typically had weaker spatial responses and taste responses were confined to place cells' firing fields. Hippocampal taste responses emerged later than in other parts of the taste system, suggesting that the hippocampus does not influence taste decisions, but rather associates the hedonic value of tastes consumed within a particular context. This could be one way that animals use past experience to locate food sources.

show abstract

Location of the Primary Gustatory Area in Humans and its Properties, Studied by Magnetoencephalography

Cited by 25 publications

References 18 publications

Interaction of taste and place coding in the hippocampus

Interaction of taste and place coding in the hippocampus

Functional Magnetic Resonance Imaging Study of Taste

Interaction of Taste and Place Coding in the Hippocampus

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