Location Propensity for Keloids in the Head and Neck

Wang, James C.; Fort, Callie L; Hom, David B.

doi:10.1089/fpsam.2020.0106

Cited by 8 publications

(4 citation statements)

References 16 publications

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“…Bagian sentral wajah (termasuk kelopak mata, bawah mata, pipi, hidung, dan bibir) memiliki kecenderungan lebih rendah untuk mengalami keloid. Jika terjadi perlukaan dan terbentuk scar, biasanya hanya berupa scar hipertrofi yang tidak berkembang menjadi keloid (11). Beberapa penelitian menunjukkan peran lokasi anatomi pada pembentukan keloid dipengaruhi oleh hal berikut: (a) individu dengan bakat genetik keloid setelah luka, tetapi tidak di setiap bagian tubuh.…”

Section: Hasil Pemeriksaanunclassified

Fraktur Os Nasal Terbuka dengan Bakat Keloid

Zachreini¹,

Siregar

2023

Galenical: j. kedokt. dan kesehat. mhs. Malikussaleh

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Fraktur os nasal adalah setiap retakan atau patah yang terjadi pada bagian tulang di organ hidung. Fraktur os nasal terbuka menyebabkan perubahan tempat dari tulang hidung yang juga disertai laserasi pada kulit atau mukoperiosteum rongga hidung. Insidensi fraktur nasal sangat tinggi dan meningkat seiring bertambahnya usia. Kasus yang dilaporkan pada dewasa sekitar 39-45% sedangkan pada remaja sekitar 45% dan 2-3 kali lebih banyak pada laki-laki. Pasien anak usia 2 tahun datang ke IGD RSU Cut Meutia dibawa oleh orang tuanya dengan keluhan luka robek pada pangkal hidungnya disertai perdarahan aktif setelah terjatuh di kamar mandi dan mengenai sudut lantai 1 jam sebelum masuk rumah sakit. Pasien dan ibu pasien memiliki riwayat keloid. Pemeriksaan fisik dijumpai luka robek 2x0,5x1 cm, terdapat nyeri tekan, krepitasi, dan perdarahan aktif. Pasien mengeluhkan nyeri pada bagian yang terluka. Pasien dilakukan pemeriksaan foto schedel dan didapatkan kesan fraktur nasal dengan deviasi septum. Pasien diberikan antibiotik dan ATS untuk mencegah infeksi, kemudian direncanakan tindakan debridemen luka dan reduksi fraktur nasal.

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Section: Hasil Pemeriksaanunclassified

Fraktur Os Nasal Terbuka dengan Bakat Keloid

Zachreini¹,

Siregar

2023

Galenical: j. kedokt. dan kesehat. mhs. Malikussaleh

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“…Most patients experience clinical symptoms such as itching and pain, which cause discomfort to the patients, both physiologically and psychologically 1 . In China, high incidence body parts of keloid disease are the earlobes, chest, shoulders, and the back 2 . The common clinical treatment methods for keloids include surgical resection, physical therapy (such as radiotherapy, laser therapy, stress therapy), and drug therapy (such as glucocorticoid, botulinum toxin A), but these treatment methods are ineffective, with a high recurrence rate 3‐5 .…”

Section: Introductionmentioning

confidence: 99%

“… 1 In China, high incidence body parts of keloid disease are the earlobes, chest, shoulders, and the back. 2 The common clinical treatment methods for keloids include surgical resection, physical therapy (such as radiotherapy, laser therapy, stress therapy), and drug therapy (such as glucocorticoid, botulinum toxin A), but these treatment methods are ineffective, with a high recurrence rate. 3 , 4 , 5 Moreover, because the specific pathogenesis of keloids is not clear, their curative treatment is difficult.…”

Section: Introductionmentioning

confidence: 99%

Bioinformatics analysis and verification of m6A related genes based on the construction of keloid diagnostic model

Yang

Wang

Zheng

et al. 2023

International Wound Journal

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Keloids are formed due to abnormal hyperplasia of the skin connective tissue. We explored the relationship between N6‐methyladenosine (m6A)‐related genes and keloids. The transcriptomic datasets (GSE44270 and GSE185309) of keloid and normal skin tissues samples were obtained from the Gene Expression Omnibus database. We constructed the m6A landscape and verified the corresponding genes using immunohistochemistry. We extracted hub genes for unsupervised clustering analysis using protein–protein interaction (PPI) network; gene ontology enrichment analysis was performed to determine the biological processes or functions affected by the differentially expressed genes (DEGs). We performed immune infiltration analysis to determine the relationship between keloids and the immune microenvironment using single‐sample gene set enrichment analysis and CIBERSORT. Differential expression of several m6A genes was observed between the two groups; insulin‐like growth factor 2 mRNA‐binding protein 3 (IGF2BP3) was significantly upregulated in keloid patients. PPI analysis elucidated six genes with significant differences between the two keloid sample groups. Enrichment analysis revealed that the DEGs were mainly enriched in cell division, proliferation, and metabolism. Moreover, significant differences in immunity‐related pathways were observed. Therefore, the results of this study will provide a reference for the elucidation of the pathogenesis and therapeutic targets of keloids.

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“…The most common areas on the body for keloids include the chest, skin overlying joints, shoulders, head and neck regions, and particularly the ears. 6,7 This abnormal healing response is difficult to treat and can occur anywhere in the body where trauma, surgery, vaccinations, blisters, acne, or body piercing have injured the skin. 8 When evaluating keloids on different parts of the body, specific morphological and anatomical characteristics should be considered.…”

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confidence: 99%

The Efficacy of CT-Based Conformal Electron Beam Radiation Therapy After Keloid Excision

et al. 2022

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BACKGROUND Adjuvant computed tomography-based conformal electron beam radiation therapy (RT) for patients with keloids enables radiation oncologists to customize the target volume with precision and deliver the maximal prescription dose while sparing normal surrounding tissues. OBJECTIVE To report treatment and cosmetic outcomes by the patient's self-assessment survey. METHODS Medical records of patients with keloids, who were treated with postoperative electron beam RT between January 2015 and December 2020, were reviewed. A total of 85 consecutive patients with 136 keloids were included in this study. Subjective cosmetic outcomes were scored by each patient using a 5-point Likert scale survey. RESULTS The median follow-up time was 29.0 months (range, 12.1-77.9 months), and local recurrence was observed in 10 lesions (7.4%). The recurrence rate of keloids occurring in the ear was 5.4%, whereas the recurrence rate of keloids occurring at other body sites was 11.4%. Among the patients who responded to the questionnaire about the cosmetic outcome, 70.2% of patients declared being either very satisfied (44.7%) or satisfied (25.5%). CONCLUSION Surgical excision, followed by CT-based conformal electron beam RT, for patients with keloids ensures a high degree of local control resulting in good cosmetic outcomes.

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Location Propensity for Keloids in the Head and Neck

Cited by 8 publications

References 16 publications

Fraktur Os Nasal Terbuka dengan Bakat Keloid

Fraktur Os Nasal Terbuka dengan Bakat Keloid

Bioinformatics analysis and verification of m6A related genes based on the construction of keloid diagnostic model

The Efficacy of CT-Based Conformal Electron Beam Radiation Therapy After Keloid Excision

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