Loci Associated with Negative Heterosis for Viability and Meat Productivity in Interspecific Sheep Hybrids

Zlobin, Alexander S.; Волкова, Н. А.; Zinovieva, N. A.; Иолчиев, Б. С.; Багиров, В. А.; Бородин, П. М.; Axenovich, Tatiana I.; Tsepilov, Yakov A.

doi:10.3390/ani13010184

Cited by 4 publications

(3 citation statements)

References 43 publications

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“…Our study also identified some genes related to meat production. Zlobin et al (2023) identified protocadherin 15 (PCDH15), a gene associated with meat productivity, between domesticated sheep (Ovis aries) and pan sheep (Ovis ammon), which is consistent with a super-dominant model of inheritance. Kizilaslan et al (2022) studied the genetic structure of growth-and linear-type traits in Akkaraman sheep and proposed 22 genes, among which transducin-like enhancer of split-4 (TLE4) and transcription factor AP-2 β (TFAP2B) were same as the genes found in this study (Kizilaslan et al, 2022).…”

Section: Fat-and Growth-related Genessupporting

confidence: 58%

Genetic diversity, population structure, and selective signature of sheep in the northeastern Tarim Basin

Wang,

Suo,

Yang

et al. 2023

Front. Genet.

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Local sheep in the northeastern Tarim Basin can adapt to dry and low-rainfall regional environments. In this study, three local sheep breeds in the northeastern Tarim Basin, LOP (LOP) sheep, Bayinbuluke (BYK) sheep, and Kunlun (KUN, also known as the Qiemo sheep) sheep, and three introduced sheep breeds, Suffolk (SUF) sheep, Dorset (APD) sheep, and Texel (TEX) sheep, were analyzed for genetic diversity, population structure, and selective signature using the Illumina OvineSNP50K BeadChip. We found that LOP, BYK, and KUN had lower observed heterozygosity and expected heterozygosity than TEX, SUF, and ADP, which were differentiated based on geographic distribution. We performed fixation index (FST) analysis on three local sheep breeds in the northeastern Tarim Basin (LOP, BYK, and KUN) and introduced sheep breeds (TEX, SUF, and ADP) to measure genetic differentiation. Nucleotide diversity (PI) analysis was performed on single-nucleotide polymorphism (SNP) data of LOP, BYK, and KUN. A total of 493 candidate genes were obtained by taking the intersection at a threshold of 5%. Among them, SMAD2, ESR2, and HAS2 were related to reproductive traits. PCDH15, TLE4, and TFAP2B were related to growth traits. SOD1, TSHR, and DNAJB5 were related to desert environmental adaptation. Analyzing the genetic patterns of local sheep in the northeastern Tarim Basin can protect the germplasm resources of local sheep and promote the development and utilization of sheep genetic resources.

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Section: Fat-and Growth-related Genessupporting

confidence: 58%

Genetic diversity, population structure, and selective signature of sheep in the northeastern Tarim Basin

Wang,

Suo,

Yang

et al. 2023

Front. Genet.

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“…Negative dominant effects have been reported in other species. Zlobin et al (2023) reported the loci associated with negative heterosis for viability and meat productivity in interspecific hybrids between domestic sheep and argali. Clasen et al (2017) observed negative heterosis effects for the period from first calving until culling in Danish Jersey × Danish Holstein and Danish Jersey × Danish Red crosses.…”

Section: Resultsmentioning

confidence: 99%

Genetic parameters for carcass and meat quality traits in Jinhua, Duroc, and their crossbred pigs

Terada,

Ohtani,

Ogawa

et al. 2023

J Animal Breeding Genetics

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Jinhua pigs have excellent meat quality and intramuscular fat content (IMF). Crossbreeding of Jinhua with Duroc pigs with high productivity was conducted to develop a new composite breed that possesses the beneficial characteristics of both breeds. The objective of this study was to estimate the crossbreeding parameters (additive breed, dominance, and epistatic loss effects) using the Kinghorn model and genetic parameters (heritability and genetic correlation) for carcass and meat quality traits by analysing the phenotypic data of Jinhua, Duroc, and their crossbred pigs. Backfat thickness at the thinnest point above the 9th to 13th thoracic vertebrae (BF), longissimus muscle area between the 4th and 5th thoracic vertebrae (LMA), meat shear force value (SFV), and IMF were measured. The additive breed effects were significant for all traits: 1.59 cm, −8.30 cm2, −6.38 lb/cm2, and 1.76% for BF, LMA, SFV, and IMF, respectively. The dominance effect was significant for LMA (7.41 cm2) and IMF (−2.46%), whereas the epistatic loss effect was significant for only LMA (−15.18 cm2). The estimated heritability values were high, ranging from 0.58 for IMF to 0.76 for LMA. A negative but non‐significant genetic correlation of −0.11 was estimated between BF and IMF; however, previous studies have reported that the genetic correlation between these traits is moderately positive in modern western pigs. Our results imply that, with the estimation of crossbreeding and genetic parameters, genetic improvement could be implemented to produce a new composite breed with good meat quality and productivity, to meet Japanese market requirements, by crossbreeding Jinhua and Duroc pigs.

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“…Occasionally, we also included specific animal (e.g., sheep, goats or cattle) as an additional keyword to refine the results. We then summarized all the previously reported genes in terms of function and animal in Additional file 2 : Table S30 [ 28 , 30 , 31 , 35 – 38 , 41 , 43 – 47 , 103 , 114 , 247 – 306 ]. To eliminate potential bias in the results of literature review, we did not use the literature including the same sheep/goat individuals as the present study for gene comparison.…”

Section: Methodsmentioning

confidence: 99%

Structural variant landscapes reveal convergent signatures of evolution in sheep and goats

Yang,

Wang,

Huang

et al. 2024

Genome Biol

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Background Sheep and goats have undergone domestication and improvement to produce similar phenotypes, which have been greatly impacted by structural variants (SVs). Here, we report a high-quality chromosome-level reference genome of Asiatic mouflon, and implement a comprehensive analysis of SVs in 897 genomes of worldwide wild and domestic populations of sheep and goats to reveal genetic signatures underlying convergent evolution. Results We characterize the SV landscapes in terms of genetic diversity, chromosomal distribution and their links with genes, QTLs and transposable elements, and examine their impacts on regulatory elements. We identify several novel SVs and annotate corresponding genes (e.g., BMPR1B, BMPR2, RALYL, COL21A1, and LRP1B) associated with important production traits such as fertility, meat and milk production, and wool/hair fineness. We detect signatures of selection involving the parallel evolution of orthologous SV-associated genes during domestication, local environmental adaptation, and improvement. In particular, we find that fecundity traits experienced convergent selection targeting the gene BMPR1B, with the DEL00067921 deletion explaining ~10.4% of the phenotypic variation observed in goats. Conclusions Our results provide new insights into the convergent evolution of SVs and serve as a rich resource for the future improvement of sheep, goats, and related livestock.

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Loci Associated with Negative Heterosis for Viability and Meat Productivity in Interspecific Sheep Hybrids

Cited by 4 publications

References 43 publications

Genetic diversity, population structure, and selective signature of sheep in the northeastern Tarim Basin

Genetic diversity, population structure, and selective signature of sheep in the northeastern Tarim Basin

Genetic parameters for carcass and meat quality traits in Jinhua, Duroc, and their crossbred pigs

Structural variant landscapes reveal convergent signatures of evolution in sheep and goats

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