Locked nucleic acid inhibits miR-92a-3p in human colorectal cancer, induces apoptosis and inhibits cell proliferation

Ahmadi, Samaneh; Sharifi, Mohammadreza; Salehi, Roya

doi:10.1038/cgt.2016.10

Cited by 27 publications

(15 citation statements)

References 43 publications

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“…The results showed that overexpression of miR-92a significantly induced growth retardation, which implicated miR-92a as playing an inhibitory role in the growth of gastric cancer [18]. Similar results were reported in Ahmadi's study in colorectal cancer [19].…”

Section: The Potential Oncogenic and Suppressive Effect Of The Mir-17supporting

confidence: 86%

Current Advancement of the miR-17-92 Cluster in Gastrointestinal Cancers

Liu

Chen

Sun

et al. 2019

IGH

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Gastrointestinal (GI) cancers, especially including esophageal, gastric and colorectal cancer, are common types of cancer with high morbidity and mortality worldwide. Despite great advances having been made for these cancers, current treatments including surgery, Radiotherapy (RT) and Chemotherapy (CT) are still far from satisfactory as these cancers are usually discovered in advanced stages that are associated with short longevity and poor outcomes. MicroRNAs (miRNAs) are short noncoding strands of RNA that regulate gene expression, affecting proliferation, development, differentiation, apoptosis, metabolism and Epithelial-mesenchymal Transition (EMT). The miR-17-92 cluster was detected as “oncomir-1”, which is involved in the onset and progression of numerous human cancers. This review presents the recent developments in knowledge about miR-17-92 clusters for diagnosing and treating GI cancers based on genetic functions, biological phenotypes, related mechanisms, biomarkers and therapeutic perspectives, which could provide a wider horizon for future use.

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Section: The Potential Oncogenic and Suppressive Effect Of The Mir-17supporting

confidence: 86%

Current Advancement of the miR-17-92 Cluster in Gastrointestinal Cancers

Liu

Chen

Sun

et al. 2019

IGH

View full text Add to dashboard Cite

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“…Furthermore, miR-92a-3p over-expression was shown to be related to acute myeloid leukemia [ 57 ]. Moreover, miR-92a-3p and miR-24-3p were associated with colorectal cancer [ 58 ] and nasopharyngeal carcinoma [ 59 ], respectively. miR-155-5p behaves as either an oncogene or an anti-oncogene in carcinogenesis, and miR-155-5p has been associated with various diseases including cancers, viral infections, inflammation, and cardiovascular diseases [ 60 ].…”

Section: Discussionmentioning

confidence: 99%

Potential biomarkers and therapeutic targets in cervical cancer: Insights from the meta-analysis of transcriptomics data within network biomedicine perspective

2018

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The malignant neoplasm of the cervix, cervical cancer, has effects on the reproductive tract. Although infection with oncogenic human papillomavirus is essential for cervical cancer development, it alone is insufficient to explain the development of cervical cancer. Therefore, other risk factors such as host genetic factors should be identified, and their importance in cervical cancer induction should be determined. Although gene expression profiling studies in the last decade have made significant molecular findings about cervical cancer, adequate screening and effective treatment strategies have yet to be achieved. In the current study, meta-analysis was performed on cervical cancer-associated transcriptome data and reporter biomolecules were identified at RNA (mRNA, miRNA), protein (receptor, transcription factor, etc.), and metabolite levels by the integration of gene expression profiles with genome-scale biomolecular networks. This approach revealed already-known biomarkers, tumor suppressors and oncogenes in cervical cancer as well as various receptors (e.g. ephrin receptors EPHA4, EPHA5, and EPHB2; endothelin receptors EDNRA and EDNRB; nuclear receptors NCOA3, NR2C1, and NR2C2), miRNAs (e.g., miR-192-5p, miR-193b-3p, and miR-215-5p), transcription factors (particularly E2F4, ETS1, and CUTL1), other proteins (e.g., KAT2B, PARP1, CDK1, GSK3B, WNK1, and CRYAB), and metabolites (particularly, arachidonic acids) as novel biomarker candidates and potential therapeutic targets. The differential expression profiles of all reporter biomolecules were cross-validated in independent RNA-Seq and miRNA-Seq datasets, and the prognostic power of several reporter biomolecules, including KAT2B, PCNA, CD86, miR-192-5p and miR-215-5p was also demonstrated. In this study, we reported valuable data for further experimental and clinical efforts, because the proposed biomolecules have significant potential as systems biomarkers for screening or therapeutic purposes in cervical carcinoma.

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“…In recent studies, it was observed that overexpression of miR-92a-3p can disrupt PI3K/Akt/mTOR pathway by targeting two negative regulatory factors of this pathway, PTEN and PHLPP [29, 31]. Different studies have reported that overexpression of miR-92a-3p is involved in the development of metastasis and correlates with survival in different malignancies [32–34]. Our study shows that miR-92a-3p is significantly overexpressed in urinary cells of NMIBC progressing patients which is in concordance with its role as oncomiR.…”

Section: Discussionmentioning

confidence: 99%

Urinary cell microRNA-based prognostic classifier for non-muscle invasive bladder cancer

et al. 2017

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Current prognostic tools for non-muscle invasive bladder cancer (NMIBC) do not have enough discriminative capacity to predict the risk of tumour progression. This study aimed to identify urinary cell microRNAs that may be useful as non-invasive predictive biomarkers of tumour progression in NMIBC patients. To this end, 210 urine samples from NMIBC patients were included in the study. RNA was extracted from urinary cells and expression of 8 microRNAs, previously described by our group, was analysed by quantitative PCR. A tumour progression predicting model was developed by Cox regression analysis and validated by bootstrapping. Regression analysis identified miR-140-5p and miR-92a-3p as independent predictors of tumour progression. The risk score derived from the model containing these two microRNAs was able to discriminate between two groups with a highly significant different probability of tumour progression (HR, 5.204; p<0.001) which was maintained when patients were stratified according to tumour risk. The algorithm was also able to identify two groups with different cancer-specific survival (HR, 3.879; p=0.021). Although the data needs to be externally validated, miRNA analysis in urine appears to be a valuable prognostic tool in NMIBC patients.

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Locked nucleic acid inhibits miR-92a-3p in human colorectal cancer, induces apoptosis and inhibits cell proliferation

Cited by 27 publications

References 43 publications

Current Advancement of the miR-17-92 Cluster in Gastrointestinal Cancers

Current Advancement of the miR-17-92 Cluster in Gastrointestinal Cancers

Potential biomarkers and therapeutic targets in cervical cancer: Insights from the meta-analysis of transcriptomics data within network biomedicine perspective

Urinary cell microRNA-based prognostic classifier for non-muscle invasive bladder cancer

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