Lockhart Clarke (1817–1880): his role in the early history of muscular dystrophy

Emery, Alan E. H.; Emery, Marcia L. H.

doi:10.1016/s0960-8966(00)00106-1

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…1) is best known for his descriptions of spinal cord anatomy, in particular the ‘posterior vesicular column’ (Clarke’s column), but also for an early account of syringomyelia (Pearce, 1990a, b). He also made important contributions to the early history of muscular dystrophy (Emery and Emery, 2000). It was noted by Pearce that, despite his remarkable achievements, and although he had been elected to membership of the Royal College of Physicians under the ‘Dispensing Clause’ in 1871, he was mysteriously never advanced to fellowship of the college.…”

Section: Lockhart Clarke’s Early Clinicopathological Studies In Amyotmentioning

confidence: 99%

“…Lockhart Clarke played an important role in the London Pathological Society, but his clinical activities achieved little reputation in the early development of neurology, at least in terms of original clinical contributions to the subject. He never held an academic position (Emery and Emery, 2000) and his obituary in The Lancet concluded: He was a man single of purpose, of noble independence and honesty, wholly free from ambition…he will be remembered, not as the popular physician, but on account of his patient and laborious researches so fruitful to medical science.…”

Section: Lockhart Clarke’s Early Clinicopathological Studies In Amyotmentioning

confidence: 99%

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Lockhart Clarke's contribution to the description of amyotrophic lateral sclerosis

Turner

Swash

Ebers

2010

Brain

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The definition of the clinicopathological entity of amyotrophic lateral sclerosis evolved over half a century. Although the definitive term amyotrophic lateral sclerosis that acknowledged both upper and lower motor neuron involvement was attributed to Jean-Martin Charcot in 1874, his initial case was published nearly a decade earlier; and it is accepted that, from at least the 1830s, several others (including Charles Bell, François-Amilcar Aran and Jean Cruveilhier) had already recognized a progressive lower motor neuron-only syndrome within a broader, clinically-defined group of disorders, termed progressive muscular atrophy. Although William Gowers first grouped the three phenotypes of amyotrophic lateral sclerosis, progressive muscular atrophy and progressive bulbar palsy together as part of the same syndrome, the term motor neuron disease, as an over-arching label, was not suggested until nearly a century later by W. Russell Brain. Augustus Jacob Lockhart Clarke (1817-80) is best known for his descriptions of spinal cord anatomy. However, in two detailed case reports from the 1860s, he carried out rigorous post-mortem neuropathological studies of what appear to be classical cases of amyotrophic lateral sclerosis. Furthermore, he recognized the additional involvement of the corticospinal tracts that distinguished this from progressive muscular atrophy. Several aspects of the exquisite clinical histories documented as part of both studies, one by Charles Bland Radcliffe, resonate with contemporary debates concerning the evolution of disease in amyotrophic lateral sclerosis. These 'past masters' still have much to teach us.

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Section: Lockhart Clarke’s Early Clinicopathological Studies In Amyotmentioning

confidence: 99%

Section: Lockhart Clarke’s Early Clinicopathological Studies In Amyotmentioning

confidence: 99%

Lockhart Clarke's contribution to the description of amyotrophic lateral sclerosis

Turner

Swash

Ebers

2010

Brain

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Jacob Augustus Lockhart Clarke (1817–1880)

2022

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The history of progressive muscular atrophy

Visser¹,

Jong²,

Visser³

2008

Neurology

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Since its first description more than a century ago, there has been much debate about the diagnostic entity progressive muscular atrophy (PMA). Initially, PMA included all forms of progressive amyotrophy. With the identification of several myogenic and neurogenic diseases and the recognition of amyotrophic lateral sclerosis (ALS), PMA was deemed to disappear as a nosologic entity at the end of the 19th century. In the last century, various other lower motor neuron syndromes were distinguished which may previously have been designated as cases of PMA. In contrast, several observations provided evidence that PMA can be linked both clinically and pathologically to ALS. Therefore, PMA should be considered as a syndromal subtype within a clinical spectrum of motor neuron diseases.

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Lockhart Clarke (1817–1880): his role in the early history of muscular dystrophy

Cited by 4 publications

References 6 publications

Lockhart Clarke's contribution to the description of amyotrophic lateral sclerosis

Lockhart Clarke's contribution to the description of amyotrophic lateral sclerosis

Jacob Augustus Lockhart Clarke (1817–1880)

The history of progressive muscular atrophy

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