Locomotion and Behavioral Toxicity in Larval Zebrafish: Background, Methods, and Data

MacPhail, Robert C.; Hunter, Deborah L.; Irons, T.D.; Padilla, Stephanie

doi:10.1002/9781118102138.ch12

Cited by 13 publications

(7 citation statements)

References 38 publications

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“…Zebrafish exhibit a range of complex behaviors that can be used as sensitive parameters to assess toxicity, including color preference, spatial recognition and locomotion [ 39 , 40 ]. The nervous system that underpins these behaviors, including the developing brain, is particularly vulnerable to oxidative stress because of its high energy demand, low level of antioxidants, and high cellular content of lipids and proteins.…”

Section: Approaches For Measuring Nanoparticle Toxicity In Zebrafimentioning

confidence: 99%

Zebrafish as a Model to Evaluate Nanoparticle Toxicity

2018

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Nanoparticles are increasingly being developed for in vivo use, from targeted drug delivery to diagnostics, where they have enormous potential, while they are also being used for a variety of applications that can result in environmental exposure for humans. Understanding how specific nanoparticles interact with cells and cell systems is essential to gauge their safety with respect to either clinical or environmental exposure. Zebrafish is being increasingly employed as a model to evaluate nanoparticle biocompatibility. This review describes this model and how it can be used to assess nanoparticle toxicity at multiple levels, including mortality, teratogenicity, immunotoxicity, genotoxicity, as well as alterations in reproduction, behavior and a range of other physiological readouts. This review also provides an overview of studies using this model to assess the toxicity of metal, metal oxide and carbon-based nanoparticles. It is anticipated that this information will inform research aimed at developing biocompatible nanoparticles for a range of uses.

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Section: Approaches For Measuring Nanoparticle Toxicity In Zebrafimentioning

confidence: 99%

Zebrafish as a Model to Evaluate Nanoparticle Toxicity

2018

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“…One important parameter for toxicity evaluation is the hatching efficiency because nanoparticles can interact with hatching enzymes [ 145 ]. Zebrafish is also a versatile organism for genotoxicity studies [ 146 , 147 , 148 , 149 ], developmental and behavioral analysis [ 150 , 151 , 152 , 153 ], immunotoxicity [ 154 , 155 ], neurotoxicity [ 156 , 157 ], and reproductive toxicity studies [ 158 ]. For example, in experiments with transgenic lines, such as Tg(flk1:eGFP), Tg(cmlc2:eGFP), Hsp70:eGFP, ARE:eGFP, FLI-1, and Nacre/fli1:EGFP, it was possible to observe the chemical-induced toxicity of nanocomposites and metal oxide nanoparticles in real time [ 159 , 160 , 161 , 162 , 163 ].…”

Section: The Potential Of Zebrafish For Increasing the Translationmentioning

confidence: 99%

The Potential of Zebrafish as a Model Organism for Improving the Translation of Genetic Anticancer Nanomedicines

Gutiérrez-Lovera

Vázquez-Ríos

Guerra‐Varela

et al. 2017

Genes

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In the last few decades, the field of nanomedicine applied to cancer has revolutionized cancer treatment: several nanoformulations have already reached the market and are routinely being used in the clinical practice. In the case of genetic nanomedicines, i.e., designed to deliver gene therapies to cancer cells for therapeutic purposes, advances have been less impressive. This is because of the many barriers that limit the access of the therapeutic nucleic acids to their target site, and the lack of models that would allow for an improvement in the understanding of how nanocarriers can be tailored to overcome them. Zebrafish has important advantages as a model species for the study of anticancer therapies, and have a lot to offer regarding the rational development of efficient delivery of genetic nanomedicines, and hence increasing the chances of their successful translation. This review aims to provide an overview of the recent advances in the development of genetic anticancer nanomedicines, and of the zebrafish models that stand as promising tools to shed light on their mechanisms of action and overall potential in oncology.

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“…hunger level) of an individual (Brown et al, 2005) and the onset of light (MacPhail et al, 2009;Cavallari, et al, 2011). For example, locomotor activity has been found to increase in anticipation of food (Cavallari et al, 2011) and to be higher in the morning than in the afternoon (MacPhail et al, 2009(MacPhail et al, , 2011. Moreover, the nutritional state of an individual has been found to be linked to its inclination to take risks (Mikheev et al, 1992;Fanta, 1997;Sih, 1997) and hungry individuals are more likely to take risks, explore their environment and be more aggressive (Wieser et al, 1992;Arber et al, 1995;Machmer & Ydenberg, 1998;Vehanen, 2003;Chapman et al, 2010;Petersen et al, 2010).…”

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confidence: 99%

Effect of hunger level and time of day on boldness and aggression in the zebrafish Danio rerio

Ariyomo

Watt

2015

Journal of Fish Biology

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The effect of two environmental variables, hunger level (fed or not fed before behavioural assays) and time of day (morning or afternoon), on the boldness and aggressiveness of male and female zebrafish Danio rerio, was tested. The results showed that neither hunger level nor time of testing influenced boldness in males and females, but hunger level significantly affected aggression in females when compared with males.

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Locomotion and Behavioral Toxicity in Larval Zebrafish: Background, Methods, and Data

Cited by 13 publications

References 38 publications

Zebrafish as a Model to Evaluate Nanoparticle Toxicity

Zebrafish as a Model to Evaluate Nanoparticle Toxicity

The Potential of Zebrafish as a Model Organism for Improving the Translation of Genetic Anticancer Nanomedicines

Effect of hunger level and time of day on boldness and aggression in the zebrafish Danio rerio

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