Locomotor activity, ultrasonic vocalization and oxytocin levels in infant CD38 knockout mice

Liu, Hong Xiang; Lopatina, Olga; Higashida, Chiharu; Tsuji, Takahiro; Kato, Ichiro; Takasawa, Shin; Okamoto, Hiroshi; Yokoyama, Shigeru; Higashida, Haruhiro

doi:10.1016/j.neulet.2008.09.084

Cited by 58 publications

(70 citation statements)

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“…Therefore, we showed here that OT-induced OT release, autoregulation of the positive feedback, is a PKC-and cADPR-dependent process in the hypothalamus and/or pituitary. As we used 10-12-week-old adult male mice, this PKC-and cADPR-dependent autoregulation of OT release is not related to female reproductive processes, but to social recognition or social behavior found in this mouse strain (Jin et al, 2007a;Liu et al, 2008). The positive feedback mechanism of OT release plays a critical and physiological role in causing uterus contraction during labor and triggering milk release from the breast tissue when infants are nursed (Moos et al, 1984;Neumann et al, 1994 and1996).…”

Section: Discussionmentioning

confidence: 95%

Oxytocin-induced elevation of ADP-ribosyl cyclase activity, cyclic ADP-riboseor Ca2+ concentrations is involved in autoregulation of oxytocin secretionin the hypothalamus and posterior pituitary in male mice

et al. 2010

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Section: Discussionmentioning

confidence: 95%

Oxytocin-induced elevation of ADP-ribosyl cyclase activity, cyclic ADP-riboseor Ca2+ concentrations is involved in autoregulation of oxytocin secretionin the hypothalamus and posterior pituitary in male mice

et al. 2010

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“…1), double immunohistochemical staining revealed high levels of CD38 immunoreactivity in many cells in the paraventricular nucleus of the hypothalamus and showed extensive colabeling with OT (Yamashita et al, 2002), while much lower CD38 expression levels and little or no detectable OT were observed in the insular cortex, which served as a control. These results suggested that CD38 may have an important role in OT release in the human hypothalamus, as in the mice (Jin et al, 2007;Liu et al, 2008). Based on this new information about the human brain, we set out to examine the human CD38 gene.…”

Section: Resultsmentioning

confidence: 99%

“…The samples were centrifuged at 0°C at 2,600 x g for 15 min and the plasma was separated off, divided into 2 tubes, and stored at -80°C. We performed the peptide assay for OT and vasopressin (AVP) as described previously (Jin et al, 2007;Liu et al, 2008).…”

Section: Enzyme Immunoassay For Ot and Vasopressinmentioning

confidence: 99%

“…Little was known about the CD38-dependent cADPR/Ca 2+ signaling pathway in the brain until recent studies in our laboratory. They showed that CD38 regulates OT secretion in the mouse hypothalamus and posterior pituitary, which is critical for mouse social behavior (Jin et al, 2007;Liu et al, 2008). The precise role of CD38 in the human hypothalamus, however, has not been clarified.…”

Section: Introductionmentioning

confidence: 99%

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Two genetic variants of CD38 in subjects with autism spectrum disorder and controls

Munesue

Yokoyama

Nakamura

et al. 2010

Neuroscience Research

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34 These authors contributed equally to the work.Key Words: CD38, oxytocin, mutation, polymorphism, autism, high-functioning autism Author information Correspondence and requests for materials should be addressed to H. Higashida (haruhiro@med.kanazawa-u.ac.jp). 3 ABSTRACTThe neurobiological basis of autism spectrum disorder (ASD) remains poorly understood.Given the role of CD38 in social recognition through oxytocin (OT) release, we hypothesized that CD38 may play a role in the etiology of ASD. Here, we first examined the immunohistochemical expression of CD38 in the hypothalamus of post-mortem brains of non-ASD subjects and found that CD38 was colocalized with OT in secretory neurons.In studies of the association between CD38 and autism, we analyzed 10 single nucleotide polymorphisms (SNPs) and mutations of CD38 by re-sequencing DNAs mainly from a case-control study in Japan, and Caucasian cases mainly recruited to the Autism Genetic Resource Exchange (AGRE). The SNPs of CD38, rs6449197 (p<0.040) and rs3796863 (p<0.005) showed significant associations with a subset of ASD (IQ>70; designated as high-functioning autism (HFA)) in the U.S. 104 AGRE family trios, but not with Japanese 188 HFA subjects. A mutation that caused tryptophan to replace arginine at amino acid residue 140 (R140W; (rs1800561, 4693C>T)) was found in 0.6%-4.6% of the Japanese population and was associated with ASD in the smaller case-control study. The SNP was clustered in pedigrees in which the fathers and brothers of T-allele-carrier probands had ASD or ASD traits. In this cohort OT plasma levels were lower in subjects with the T allele than in those without. One proband with the T allele who was taking nasal OT spray showed relief of symptoms. The two variant CD38 poloymorphysms tested may be of interest with regard of the pathophysiology of ASD.4

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“…Oxytocin application in decerebrate rat neonates reduced vocalizations in response to electrical stimulation of the whiskers, a pain-inducing stimulus (Mazzuca et al, 2011). CD38 has been identified as a potent releaser of oxytocin in the hypothalamus (Jin et al, 2007), and these mice have altered social behavior in the neonatal period (Higashida et al, 2010), including a reduction in isolation-induced ultrasonic vocalizations (Liu et al, 2008). Therefore, as presence of oxytocin, total lack of oxytocin, or poor oxytocin secretion, all result in reduced separation or stress-induced vocalizations, the role of oxytocin in ultrasonic vocalizations in neonatal rodents is unclear.…”

Section: Behavioral Influence During Developmentmentioning

confidence: 99%

Developmental Perspectives on Oxytocin and Vasopressin

Hammock

2014

Neuropsychopharmacol

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The related neuropeptides oxytocin and vasopressin are involved in species-typical behavior, including social recognition behavior, maternal behavior, social bonding, communication, and aggression. A wealth of evidence from animal models demonstrates significant modulation of adult social behavior by both of these neuropeptides and their receptors. Over the last decade, there has been a flood of studies in humans also implicating a role for these neuropeptides in human social behavior. Despite popular assumptions that oxytocin is a molecule of social bonding in the infant brain, less mechanistic research emphasis has been placed on the potential role of these neuropeptides in the developmental emergence of the neural substrates of behavior. This review summarizes what is known and assumed about the developmental influence of these neuropeptides and outlines the important unanswered questions and testable hypotheses. There is tremendous translational need to understand the functions of these neuropeptides in mammalian experience-dependent development of the social brain. The activity of oxytocin and vasopressin during development should inform our understanding of individual, sex, and species differences in social behavior later in life.

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Locomotor activity, ultrasonic vocalization and oxytocin levels in infant CD38 knockout mice

Cited by 58 publications

References 30 publications

Oxytocin-induced elevation of ADP-ribosyl cyclase activity, cyclic ADP-riboseor Ca2+ concentrations is involved in autoregulation of oxytocin secretionin the hypothalamus and posterior pituitary in male mice

Oxytocin-induced elevation of ADP-ribosyl cyclase activity, cyclic ADP-riboseor Ca2+ concentrations is involved in autoregulation of oxytocin secretionin the hypothalamus and posterior pituitary in male mice

Two genetic variants of CD38 in subjects with autism spectrum disorder and controls

Developmental Perspectives on Oxytocin and Vasopressin

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