Locomotor effects of ethanol and acetaldehyde after peripheral and intraventricular injections in Swiss and C57BL/6J mice

Histamine and H3 receptor-dependent mechanisms regulate ethanol stimulation and conditioned place preference in mice

“…We found that a low dose of ethanol induced a clear stimulation of locomotor activity with a peak effect seen at 5-min post-injection. In contrast to our finding, several studies have reported no stimulation of locomotor activity by low doses of ethanol in C57BL/6 mice, most commonly in C57BL/6J sub-strain from the Jackson laboratories (Randall et al 1975;Frye and Breese 1981;Tambour et al 2006). However, there are also studies showing ethanol-induced activation in C57BL/6J mice (Middaugh et al 1987;Crabbe et al 1994Crabbe et al , 2005.…”

“…Furthermore, we used a long habituation period in the novel environment prior to ethanol administration, which could be an important factor affecting the outcome of the study. In accordance with this, Middaugh et al (1992) showed a stimulatory response to ethanol after habituation in C57BL/6 mice, whereas Tambour et al (2006) used no habituation and showed depression or no effect by 1-2 g/kg ethanol in this strain. It is also possible that the substrain from Scanbur that we used in our study, although originally received from the Jackson Laboratories, has genetically drifted and shows different behavioral patterns from those mice where the lack of ethanol stimulation was observed originally.…”

What is in that Drink: The Biological Actions of Ethanol, Acetaldehyde, and Salsolinol

“…Quertemont and De Witte (2001) reported that rats showed a dose dependent stimulus preference when ACD was administered peripherally. Much like EtOH, ICV-administered ACD at lower doses, produced an elevation in locomotor activity in rats (Correa et al, 2003), while peripheral and central administration of high doses of ACD produced motor depression in both rats and mice (Durlach et al, 1988;Holtzman & Schneider, 1974;Myers et al, 1987;Quertemont et al, 2004;Tambour et al, 2006). Similar biphasic effects on locomotor activity have been observed following vapor exposure to ACD .…”

Ontogeny of the stimulant and sedative effects of ethanol in male and female Swiss mice: gradual changes from weaning to adulthood

“…Although the locomotor activity was recorded for 30 min in the test sessions in experiments 1 and 3, statistical analyses were performed on the mean locomotor activity during the first 10 min on the basis of our previous studies in adult Swiss mice showing that significant locomotor stimulant effects of ethanol were mainly observed during this time interval (Tambour et al 2006). However, it is noteworthy that analyzing the mean locomotor activity during the entire 30-min test sessions only slightly altered the statistical significance of the reported effects.…”