Locomotor exercise and circadian rhythms in mammals

Hughes, Alun

doi:10.1016/j.cophys.2018.07.001

Cited by 2 publications

(1 citation statement)

References 64 publications

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“…Environmental light and internal arousal are key cues (or Zeitgebers) that synchronize the SCN with the 24 h external world 17 , 18 . Mice lacking VIP or VPAC 2 receptor do not express endogenous 24 h rhythms in behavior 13 , 19 , 20 , while targeted deficiency in SCN VGAT expression attenuates mouse locomotor rhythms without altering their ~24 h period 16 .…”

Section: Introductionmentioning

confidence: 99%

Timed daily exercise remodels circadian rhythms in mice

et al. 2021

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Regular exercise is important for physical and mental health. An underexplored and intriguing property of exercise is its actions on the body’s 24 h or circadian rhythms. Molecular clock cells in the brain’s suprachiasmatic nuclei (SCN) use electrical and chemical signals to orchestrate their activity and convey time of day information to the rest of the brain and body. To date, the long-lasting effects of regular physical exercise on SCN clock cell coordination and communication remain unresolved. Utilizing mouse models in which SCN intercellular neuropeptide signaling is impaired as well as those with intact SCN neurochemical signaling, we examined how daily scheduled voluntary exercise (SVE) influenced behavioral rhythms and SCN molecular and neuronal activities. We show that in mice with disrupted neuropeptide signaling, SVE promotes SCN clock cell synchrony and robust 24 h rhythms in behavior. Interestingly, in both intact and neuropeptide signaling deficient animals, SVE reduces SCN neural activity and alters GABAergic signaling. These findings illustrate the potential utility of regular exercise as a long-lasting and effective non-invasive intervention in the elderly or mentally ill where circadian rhythms can be blunted and poorly aligned to the external world.

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Section: Introductionmentioning

confidence: 99%

Timed daily exercise remodels circadian rhythms in mice

et al. 2021

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Phase-shift of cellular coupling induces the anti-phase synchronization between the left and right suprachiasmatic nucleus

Gu¹,

Zhang²,

Zheng³

et al. 2022

Int. J. Mod. Phys. C

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Exposed to the constant light, the master clock located in the bilaterally paired suprachiasmatic nucleus (SCN) above the optic chiasma exhibits three rhythmic behaviors in hamsters. Some hamsters remain or lose circadian rhythms due to synchronization or desynchronization between the SCN neurons, respectively. Interestingly, the other hamsters show a phenomenon called “split”, in which the left SCN and right SCN oscillate with a stable anti-phase. In this paper, a modified Kuramoto model is built to explain these three rhythmic behaviors, where the phase-shift of cellular coupling is taken into account. Three cases of phase-shifts are considered, including that first case exists in all the SCN neurons, second case exists between the left and right SCN, and the last case exists within each group. We found that the phase-shift is able to induce the anti-phase synchronization between the left SCN and right SCN in the former two cases, but eliminate this anti-phase synchronization in the latter case. Our findings provide an alternative explanation for the emergency of the split and shed light on the collective behaviors of the SCN neurons.

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Locomotor exercise and circadian rhythms in mammals

Cited by 2 publications

References 64 publications

Timed daily exercise remodels circadian rhythms in mice

Timed daily exercise remodels circadian rhythms in mice

Phase-shift of cellular coupling induces the anti-phase synchronization between the left and right suprachiasmatic nucleus

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