Locoregional and Distant Recurrence Patterns in Young versus Elderly Women Treated for Breast Cancer

Rudra, Soumon; Yu, David S.; En, YU; Switchenko, Jeffrey M.; Mister, Donna; Torres, Mylin A.

doi:10.1155/2015/213123

Cited by 11 publications

(8 citation statements)

References 19 publications

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“…[17][18][19] The tumors are often poorly differentiated and may present higher rates of vascular and lymphatic embolization, as well as a higher locoregional recurrence rate. 9,20 This was also verified in the current study, where most of the tumors showed a high nuclear grade and high proliferative rates, associated with important lymph node involvement.…”

Section: Discussionsupporting

confidence: 85%

Breast cancer features in women under the age of 40 years

Eugênio

Souza

Chojniak

et al. 2016

Rev. Assoc. Med. Bras.

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Results:The mean age at diagnosis of primary breast cancer was 34 years. Only 11 patients (9.0%) had a family history of breast or ovarian cancer in first-degree relative. Ninety-two (92) patients sought medical attention after showing breast symptoms, and the presence of a palpable nodule was the main complaint. One hundred and twenty-two (122) primary tumors were diagnosed, of which 112 were invasive (95%). The most common histological type was invasive ductal carcinoma (73.8%). Luminal B was the predominant molecular subtype (42.6%). Ultrasonography was positive in 94.5% of the cases and the most common finding were nodules (94.8%). At mammography, the malignancy was observed in 92.8% and the presence of suggestive calcifications was the dominant feature. The MRI was positive in 98% of patients, and mass lesions were the most common. Conclusion: Most cases of breast cancer diagnosed in patients under the age of 40 years, in our population, had symptoms at diagnosis and tumor with more aggressive biological behavior. Despite the ultrasound has been the most widely used method, we found improved characterization of breast lesions when also used mammography and MRI.

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Section: Discussionsupporting

confidence: 85%

Breast cancer features in women under the age of 40 years

Eugênio

Souza

Chojniak

et al. 2016

Rev. Assoc. Med. Bras.

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“…Among them, 49% of patients (n=384) were young and 51% of patients (n=395) were elder. The median age of young and elder patients was 30 (19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) and 74 (70-87) years, respectively. The co-morbidities were higher in the elderly (10% vs. 62%, p<0.001).…”

Section: Patient Characteristicsmentioning

confidence: 99%

The Comparision of Breast Cancer in the Young and Elderly Patients

Erpolat¹

2019

TJ Oncol

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To compare the tumor characteristics, treatment approaches, recurrence patterns and survival results rates of young and elderly patients with breast cancer. METHODS In this study, Between between 2000-2013, a total of 779 patients were treated for breast cancer at nine radiation oncology departments were evaluated retrospectively. Three-hundred eight-four of these patients were young (≤35 years), and 395 of those the patients were elderly (≥70 years). RESULTS Young patients were more likely to present with aggressive tumor features. They were more often received comprehensive lymphatic irradiation, tumor bed boost and intense chemotherapy. No difference was found for 5 and 10-year loco-regional recurrence-free survival rates were (96% and 93% for young, 97% and 97% for elderly). The 5 and 10-year distant recurrence-free survival rates were lower in the young patients (77% and 67% for young, 85% and 85% for elderly, p<0.0001). No difference was found in 5 and 10-year breast cancer-specific survival (91% and 79% for young, 92% and 87% for elderly). The 5 and 10-year overall survival rates were higher in the young patients (92% and 78% for young, 78% and 63% for elderly, p<0.0001). CONCLUSION The reason for the similarity between the age groups in terms ofregarding loco-regional recurrence-free survival can be more comprehensive lymphatic irradiation and tumor bed boost, the young patients received. The distant recurrence-free survival rates rates were significantly lower in the young patients even though they received more intensive chemotherapy. Future studies aimed at more effective systemic regimens to decrease distant recurrence in young patients are warranted.

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“…Studies found that younger patients are more likely to be diagnosed with stage IV disease at first presentation with breast cancer [32][33][34][35] . A study of the incidence and survival rates of women with breast cancer from the SEER database found a small but statistically significant increase (~ 2% per year) in the incidence of de novo metastatic breast cancer in patients aged < 40 years 35 .…”

Section: Clinicopathological Characteristics Of Breast Cancer In Younmentioning

confidence: 99%