Locoregional Recurrence and Survival After Curative Resection of Adenocarcinoma of the Colon1

Read, Thomas E.; Mutch, Matthew G.; Chang, Benjamin W; McNevin, Michael S.; Fleshman, James W.; Birnbaum, Elisa H.; Fry, Robert D.; Caushaj, Philip F.; Kodner, Ira J.

doi:10.1016/s1072-7515(02)01224-3

Cited by 133 publications

(81 citation statements)

References 41 publications

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“…In other series, recurrence rates may range from 4-16% 22,23 . Tumor perforation, advanced-stage disease, and poor differentiation appear to increase recurrence after curative treatment 24 .…”

Section: Discussionmentioning

confidence: 95%

Comparative evaluation of oncologic outcomes in colon cancer

et al. 2016

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PURPOSE:In this paper we report clinical variables on colon cancer series. Oncological outcomes were compared to low-income and high-income countries. METHODS:We analysed a prospective database of 51 colon cancer patients submitted to primary tumor resection between 2010 and 2011, showing clinical variables and oncologic outcomes.RESULTS: R0 resection obtained in 80.4%, 21.6% of patients was TNM stage IV, and only 13.7% showed TNM stage I. Diseasefree survival was 32 months, overall survival was 46 months, and the tumoral recurrence rate was 9.8%. Univariate analysis showed association of serum CEA levels ≥ 5 ng/dl (p= 0.004), presence of metastasis at diagnosis (p= 0.012), compromised surgical margins (p < 0.001) and poorer tumor differentiation (p= 0.041) to death. Multivariate analysis identified compromised surgical margins as an independent risk factor for death due to colon cancer (P=0.003; odds ratio=0.36; 95% confidence interval=0.004-0.33). Nowadays, 62.7% of patients are alive. CONCLUSION:Recurrence rate, disease-free survival and overall survival was similar to those observed in more developed countries.Serum CEA levels ≥ 5 ng/dl, the presence of metastasis at diagnosis, compromised surgical margins and poorer tumor differentiation were associated with death. A compromised surgical margin was the only independent risk factor for death.

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Section: Discussionmentioning

confidence: 95%

Comparative evaluation of oncologic outcomes in colon cancer

et al. 2016

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“…Colon cancer has been shown to have risk of PE of 1-3.1% [22,23]. The highest incidence of a VTE is within the first 6 months of diagnosis compared to after 2 years; 5% and 0.6% respectively [22].…”

Section: Discussionmentioning

confidence: 99%

Left Atrial Myxoma With Concurrent Saddle Pulmonary Embolism and Duke’s B Colorectal Adenocarcinoma

Mehra

2013

J Med Cases

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A 64-year-old male with previous Duke's B adenocarcinoma of the colon, successfully treated with surgery and chemotherapy presented several months later with dyspnoea and atrial fibrillation. Investigations showed that he had a left atrial myxoma and a concurrent saddle pulmonary embolus. Full anticoagulation with unfractioned heparin was administered followed by surgical resection of the myxoma. Links between pulmonary emboli and underlying carcinoma are well established. However, to our knowledge, this is only the second case in the English literature where a patient has had both an adenocarcinoma of the colon and a myxoma. There are no links between a pulmonary saddle embolism and left atrial myxoma or between a right sided myxoma and a pulmonary saddle embolus and where the embolism is not a fragment of the myxoma.

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“…Amerikan NCCN rehberinde, çıkarılması gereken minimal lenf nodu sayısı hakkında, 7, 9, 13, 20 ve 30 değerlerini veren kaynaklar olduğu bildirilmektedir (10 Lenf nodu pozitifliği kolorektal kanserlerde en önemli prognostik parametrelerden birisidir (4-7). Lenf nodu metastazı, sağkalım dışında lokorejyonel nüks açısından da en önemli risk faktörle-rinden biridir (24,25). Bizim çalışmamızda, metastatik lenf nodu sayısı (R=0,42; p<0,0001) ve lenf nodu evresi (R=0,44; p<0,0001), sağkalım üzerine olumsuz etkili olarak bulunmuşlardır.…”

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Relationship of Lymph Node Ratio, Standard Prognostic Factors and Survival in Patients with Colorectal Cancer

İlgün¹,

Yıldırım²,

Şit³

et al. 2013

JAREM

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ÖZETAmaç: Kolorektal kanserli hastalarda, standart faktörlerin yanı sıra, tutulu lenf nodlarının çıkarılan lenf nodlarına oranının (LNR), sağkalımla olan ilişki-sinin belirlenmesi hedeflenmiştir.Yöntemler: Ocak 2003-Mart 2010 yılları arasında kolorektal kanser nedeniyle ameliyat edilen ve istenen kriterleri sağlayan 72 hastanın dosyaları, T, N ve M durumu ve evreleri, lenfovasküler ve perinöral invazyon varlığı, çıkarılan lenf nodu sayısı, tutulu lenf nodu sayısı, lenf nodu kapsül invazyonu varlığı ve LNR açısından incelenmiş ve bu parametrelerin sağkalımla ilişkileri retrospektif olarak araştırılmıştır.Bulgular: Kolorektal kanserli hastaların sağkalımlarıyla, LNR, lenf nodu evresi, tutulu lenf nodu sayısı, TNM evresi, PNI ve lenf nodu kapsül invazyonu varlığının korelasyon gösterdiği belirlenmiştir.Sonuç: LNR ve lenf nodu evresi, incelenen parametreler arasında sağkalımla en yüksek ilişkili parametreler olarak bulunmuştur. (JAREM 2013; 3: 14-8) Anahtar Sözcükler: Kolorektal kanser, lenf nodu oranı, sağkalım, prognoz ABSTRACT Objective: The aim of our study is to investigate the relationship between overall survival and lymph node ratio (the number of positive lymph nodes divided by total number of lymph nodes) (LNR) as well as other standard prognostic factors in patients who underwent surgery for colorectal cancer.Methods: A retrospective study was performed to analyse the data collected for 72 patients who underwent surgery with the diagnosis of colorectal cancer from January 2003 to March 2010. The variables such as T, N and M stage, lymphovascular and perineural invasion, number of retrived lymph nodes, number of metastatic lymph nodes, lymph node capsule invasion, LNR and their effects on overall survival were analysed.Results: LNR, lymph node stage, number of metastatic lymph nodes, TNM stage, perineural invasion and lymph node capsule invasion had significant effects on overall survival.Conclusion: LNR and lymph node stage were the most significant variables associated with overall survival. (JAREM 2013; 3: 14-8)

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Locoregional Recurrence and Survival After Curative Resection of Adenocarcinoma of the Colon1

Cited by 133 publications

References 41 publications

Comparative evaluation of oncologic outcomes in colon cancer

Comparative evaluation of oncologic outcomes in colon cancer

Left Atrial Myxoma With Concurrent Saddle Pulmonary Embolism and Duke’s B Colorectal Adenocarcinoma

Relationship of Lymph Node Ratio, Standard Prognostic Factors and Survival in Patients with Colorectal Cancer

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