Locoregional Thermal and Chemical Tumor Ablation: Review of Clinical Applications and Potential Opportunities for Use in Low- and Middle-Income Countries

Quang, Tri T.; Yang, Jeffrey; Mikhail, Andrew S.; Wood, Bradford J.; Ramanujam, Nimmi; Mueller, Jenna L.

doi:10.1200/go.23.00155

JCO Global Oncology

2023

DOI: 10.1200/go.23.00155

|View full text |Cite

Locoregional Thermal and Chemical Tumor Ablation: Review of Clinical Applications and Potential Opportunities for Use in Low- and Middle-Income Countries

Tri T. Quang,

Jeffrey Yang,

Andrew S. Mikhail

et al.

Abstract: This review highlights opportunities to develop accessible ablative therapies to reduce the cancer burden in LMICs.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 125 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Light‐activatable minimally invasive ethyl cellulose ethanol ablation: Biodistribution and potential applications

Yang,

Ma,

Quinlan

et al. 2024

Bioengineering & Transla Med

View full text Add to dashboard Cite

While surgical resection is a mainstay of cancer treatment, many tumors are unresectable due to stage, location, or comorbidities. Ablative therapies, which cause local destruction of tumors, are effective alternatives to surgical excision in several settings. Ethanol ablation is one such ablative treatment modality in which ethanol is directly injected into tumor nodules. Ethanol, however, tends to leak out of the tumor and into adjacent tissue structures, and its biodistribution is difficult to monitor in vivo. To address these challenges, this study presents a cutting‐edge technology known as Light‐Activatable Sustained‐Exposure Ethanol Injection Technology (LASEIT). LASEIT comprises a three‐part formulation: (1) ethanol, (2) benzoporphyrin derivative, which enables fluorescence‐based tracking of drug distribution and the potential application of photodynamic therapy, and (3) ethyl cellulose, which forms a gel upon injection into tissue to facilitate drug retention. In vitro drug release studies showed that ethyl cellulose slowed the rate of release in LASEIT by 7×. Injections in liver tissues demonstrated a 6× improvement in volume distribution when using LASEIT compared to controls. In vivo experiments in a mouse pancreatic cancer xenograft model showed LASEIT exhibited significantly stronger average radiant efficiency than controls and persisted in tumors for up to 7 days compared to controls, which only persisted for less than 24 h. In summary, this study introduced LASEIT as a novel technology that enabled real‐time fluorescence monitoring of drug distribution both ex vivo and in vivo. Further research exploring the efficacy of LASEIT is strongly warranted.

show abstract

Light‐activatable minimally invasive ethyl cellulose ethanol ablation: Biodistribution and potential applications

Yang,

Ma,

Quinlan

et al. 2024

Bioengineering & Transla Med

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Locoregional Thermal and Chemical Tumor Ablation: Review of Clinical Applications and Potential Opportunities for Use in Low- and Middle-Income Countries

Abstract: This review highlights opportunities to develop accessible ablative therapies to reduce the cancer burden in LMICs.

Cited by 1 publication

References 125 publications

Light‐activatable minimally invasive ethyl cellulose ethanol ablation: Biodistribution and potential applications

Light‐activatable minimally invasive ethyl cellulose ethanol ablation: Biodistribution and potential applications

Contact Info

Product

Resources

About