Locus coeruleus-norepinephrine modulation of sensory processing and perception: A focused review

McBurney-Lin, Jim; Ju, Lu; Zuo, Yi; Yang, Hongdian

doi:10.1016/j.neubiorev.2019.06.009

Cited by 89 publications

(73 citation statements)

References 155 publications

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“…The prevailing interpretation emerging from these studies is that neuromodulators gate cortical plasticity by enhancing sensory perception, and by promoting patterns of cortical activity suitable for plasticity induction via controlling network excitability. This is consistent with a wealth of studies documenting that neuromodulators improve perception in vivo (see Gelbard-Sagiv et al, 2018;Jacob and Nienborg, 2018;McBurney-Lin et al, 2019;Nadim and Bucher, 2014 for reviews) also affect cellular intrinsic excitability and synaptic inhibition to gate the induction of Hebbian plasticity in vitro (see Brzosko et al, 2019;Palacios-Filardo and Mellor, 2019;Pawlak et al, 2010 for reviews). We propose an additional and different mode of action: direct control of the expression, not the induction, of Hebbian plasticity via the Gq/Gs based pull-push metaplasticity mechanism that we previously demonstrated in vitro, in slices.…”

Section: Discussionsupporting

confidence: 79%

Pull-Push Neuromodulation of Cortical Plasticity Enables Rapid Bi-Directional Shifts in Ocular Dominance

Hong

Huang

Severín

et al. 2019

Preprint

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Neuromodulatory systems are essential for remodeling glutamatergic connectivity during experience-dependent cortical plasticity. This permissive/enabling function of neuromodulators has been associated with their capacity to facilitate the induction of Hebbian forms of long-term potentiation (LTP) and depression (LTD) by affecting cellular and network excitability. In vitro studies indicate that neuromodulators can also affect the expression of Hebbian plasticity in a pull-push manner: receptors coupled to the G-protein Gs promote the expression of LTP at the expense of LTD, and Gq-coupled receptors promote LTD at the expense of LTD. Here we show that the pull-push mechanism can be recruited in vivo by pairing brief monocular stimulation with pharmacological or chemogenetical activation of Gs-or Gq-coupled receptors to respectively enhance or reduce visual cortical responses. These changes were stable, can be induced in adults after the termination of the critical period for juvenile ocular dominance plasticity, and can rescue deficits induced by prolonged monocular deprivation.

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Section: Discussionsupporting

confidence: 79%

Pull-Push Neuromodulation of Cortical Plasticity Enables Rapid Bi-Directional Shifts in Ocular Dominance

Hong

Huang

Severín

et al. 2019

Preprint

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“…The most prominent effect of the NA is the modulation of synaptic transmission and various forms of plasticity (Harley, 1987;Mouradian et al, 1991;Sara, 2009), which are analogous to those of DA (Seamans and Yang, 2004;Tritsch and Sabatini, 2012;Froemke, 2015). In various sensory systems, both dopaminergic and noradrenergic systems were effective in remodeling the tuning properties of the cortical neurons (Bao et al, 2001;Manunta and Edeline, 2004;Edeline et al, 2011;Martins and Froemke, 2015;McBurney-Lin et al, 2019;Waterhouse and Navarra, 2019). Notably, both systems also contribute to the maintenance and transitions of global brain states, wakefulness, arousal, attention, and memory consolidation (Berridge, 2008;Carter et al, 2010;Lee and Dan, 2012;Eban-Rothschild et al, 2016;Fazlali et al, 2016;Sara, 2017;Schicknick et al, 2019).…”

Section: Physiological Role Dopamine Noradrenalinementioning

confidence: 99%

Dopamine and Noradrenaline in the Brain; Overlapping or Dissociate Functions?

Ranjbar-Slamloo

Fazlali

2020

Front. Mol. Neurosci.

161

101

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Dopamine and noradrenaline are crucial neuromodulators controlling brain states, vigilance, action, reward, learning, and memory processes. Ventral tegmental area (VTA) and Locus Coeruleus (LC) are canonically described as the main sources of dopamine (DA) and noradrenaline (NA) with dissociate functions. A comparison of diverse studies shows that these neuromodulators largely overlap in multiple domains such as shared biosynthetic pathway and co-release from the LC terminals, convergent innervations, non-specificity of receptors and transporters, and shared intracellular signaling pathways. DA-NA interactions are mainly studied in prefrontal cortex and hippocampus, yet it can be extended to the whole brain given the diversity of catecholamine innervations. LC can simultaneously broadcast both dopamine and noradrenaline across the brain. Here, we briefly review the molecular, cellular, and physiological overlaps between DA and NA systems and point to their functional implications. We suggest that DA and NA may function in parallel to facilitate learning and maintain the states required for normal cognitive processes. Various signaling modules of NA and DA have been targeted for developing of therapeutics. Understanding overlaps of the two systems is crucial for more effective interventions in a range of neuropsychiatric conditions.

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“…The role of LC phasic response in mediating the orienting response and attention is well known 16 . Salient stimuli elicit phasic discharge of LC neurons 17 , 18 and associated noradrenaline (NA) release in the LC forebrain targets affects sensory processing 19 , 20 , including auditory 21 – 23 . The results of pharmacological and lesion studies suggested that the LC-NA system exerts an excitatory effect on the ASR circuit 24 – 27 .…”

Section: Introductionmentioning

confidence: 99%

Phasic activation of the locus coeruleus attenuates the acoustic startle response by increasing cortical arousal

Yang

Logothetis

Eschenko

2021

Sci Rep

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An alerting sound elicits the Acoustic Startle Response (ASR) that is dependent on the sound volume and organisms’ state, which is regulated by neuromodulatory centers. The locus coeruleus (LC) neurons respond to salient stimuli and noradrenaline release affects sensory processing, including auditory. The LC hyperactivity is detrimental for sensorimotor gating. We report here that priming microstimulation of the LC (100-ms at 20, 50, and 100 Hz) attenuated the ASR in rats. The ASR reduction scaled with frequency and 100 Hz-stimulation mimicked pre-exposure to a non-startling tone (prepulse). A rapid (~ 40 ms) EEG desynchronization following the LC stimulation suggested that the ASR reduction was due to elevated cortical arousal. The effects of LC stimulation on the ASR and EEG were consistent with systematic relationships between the ASR, awake/sleep state, and the cortical arousal level; for that matter, a lower ASR amplitude corresponded to a higher arousal level. Thus, the LC appears to modulate the ASR circuit via its diffuse ascending projections to the forebrain saliency network. The LC modulation directly in the brainstem and/or spinal cord may also play a role. Our findings suggest the LC as a part of the brain circuitry regulating the ASR, while underlying neurophysiological mechanisms require further investigation.

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Locus coeruleus-norepinephrine modulation of sensory processing and perception: A focused review

Cited by 89 publications

References 155 publications

Pull-Push Neuromodulation of Cortical Plasticity Enables Rapid Bi-Directional Shifts in Ocular Dominance

Pull-Push Neuromodulation of Cortical Plasticity Enables Rapid Bi-Directional Shifts in Ocular Dominance

Dopamine and Noradrenaline in the Brain; Overlapping or Dissociate Functions?

Phasic activation of the locus coeruleus attenuates the acoustic startle response by increasing cortical arousal

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