Locus coeruleus tyrosine hydroxylase positive neurons mediated the peripheral and central therapeutic effects of transcutaneous auricular vagus nerve stimulation (taVNS) in MRL/lpr mice

Lv, Hongjie; Yu, Xiu; Wang, Ping; Luo, Mengxian; Luo, Yijun; Lu, Haimei; Wang, Keer; Xi, Anran; Wen, Chengping; Xu, Zhenghao

doi:10.1016/j.brs.2023.12.008

Cited by 4 publications

(1 citation statement)

References 57 publications

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“…This may then activate the caudal ventrolateral medulla to inhibit the rostral ventrolateral medulla, thus reducing the sympathetic outflow (Schreihofer and Guyenet 2002), as observed in humans (Clancy et al 2014). In particular, a recent study in mice showed that the central immune effect as well as the peripheral reduction of sympathetic outflow induced by tVNS may be mediated in part by the activation of locus coeruleus tyrosine hydroxylase-positive neurons (Lv et al 2024). In addition, the NTS may also activate the dorsal motor nucleus of the vagus and the nucleus ambiguous, thereby increasing vagal outflow (Frangos et al 2015).…”

Section: Defining the Best Tvns Protocolmentioning

confidence: 99%

Impact of optimized transcutaneous auricular vagus nerve stimulation on cardiac autonomic profile in healthy subjects and heart failure patients

Maestri,

Pinna,

Robbi

et al. 2024

Physiol. Meas.

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Objective. To determine the optimal frequency and site of stimulation for transcutaneous vagus nerve stimulation (tVNS) to induce acute changes in the autonomic profile (heart rate (HR), heart rate variability (HRV)) in healthy subjects (HS) and patients with heart failure (HF). Approach. We designed three single-blind, randomized, cross-over studies: (1) to compare the acute effect of left tVNS at 25 Hz and 10 Hz (n = 29, age 60 ± 7 years), (2) to compare the acute effect of left and right tVNS at the best frequency identified in study 1 (n = 28 age 61 ± 7 years), and (3) to compare the acute effect of the identified optimal stimulation protocol with sham stimulation in HS and HF patients (n = 30, age 59 ± 5 years, and n = 32, age 63 ± 7 years, respectively). Main results. In study 1, left tragus stimulation at 25 Hz was more effective than stimulation at 10 Hz in decreasing HR (−1.0 ± 1.2 bpm, p < 0.001 and −0.5 ± 1.6 bpm, respectively) and inducing vagal effects (significant increase in RMSSD, and HF power). In study 2, the HR reduction was greater with left than right tragus stimulation (−0.9 ± 1.5 bpm, p < 0.01 and −0.3 ± 1.4 bpm, respectively). In study 3 in HS, left tVNS at 25 Hz significantly reduced HR, whereas sham stimulation did not (−1.1 ± 1.2 bpm, p< 0.01 and −0.2 ± 2.9 bpm, respectively). In HF patients, both active and sham stimulation produced negligible effects. Significance. Left tVNS at 25 Hz is effective in acute modulation of cardiovascular autonomic control (HR, HRV) in HS but not in HF patients (NCT05789147).

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Section: Defining the Best Tvns Protocolmentioning

confidence: 99%

Impact of optimized transcutaneous auricular vagus nerve stimulation on cardiac autonomic profile in healthy subjects and heart failure patients

Maestri,

Pinna,

Robbi

et al. 2024

Physiol. Meas.

View full text Add to dashboard Cite

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Transcutaneous auricular vagus nerve stimulation as a novel therapy connecting the central and peripheral systems: a review

Zou,

Zhou,

Zhang

et al. 2024

International Journal of Surgery

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Currently, clinical practice and scientific research mostly revolve around a single disease or system, but the single disease-oriented diagnostic and therapeutic paradigm needs to be revised. This review describes how transcutaneous auricular vagus nerve stimulation (taVNS), a novel noninvasive neuromodulation approach, connects the central and peripheral systems of the body. Through stimulation of the widely distributed vagus nerve from the head to the abdominal cavity, this therapy can improve and treat central system disorders, peripheral system disorders, and central-peripheral comorbidities caused by autonomic dysfunction. In the past, research on taVNS has focused on the treatment of central system disorders by modulating this brain nerve. As the vagus nerve innervates the heart, lungs, liver, pancreas, gastrointestinal tract, spleen and other peripheral organs, taVNS could have an overall modulatory effect on the region of the body where the vagus nerve is widespread. Based on this physiological basis, we summarize the existing evidence of the taVNS ability to regulate cardiac function, adiposity, glucose levels, gastrointestinal function, and immune function, among others, to treat peripheral system diseases, and complex diseases with central and peripheral comorbidities. This review shows the successful examples and research progress of taVNS using peripheral neuromodulation mechanisms from more perspectives, demonstrating the expanded scope and value of taVNS to provide new ideas and approaches for holistic therapy from both central and peripheral perspectives.

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Feasibility and effectiveness of transcutaneous auricular vagus nerve stimulation (taVNS) in awake mice

Yu,

Yao,

Liu

et al. 2024

CNS Neurosci Ther

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AimsTranscutaneous auricular vagus nerve stimulation (taVNS) is widely used to treat a variety of disorders because it is noninvasive, safe, and well tolerated by awake patients. However, long‐term and repetitive taVNS is difficult to achieve in awake mice. Therefore, developing a new taVNS method that fully mimics the method used in clinical settings and is well‐tolerated by awake mice is greatly important for generalizing research findings related to the effects of taVNS. The study aimed to develop a new taVNS device for use in awake mice and to test its reliability and effectiveness.MethodsWe demonstrated the reliability of this taVNS device through retrograde neurotropic pseudorabies virus (PRV) tracing and evaluated its effectiveness through morphological analysis. After 3 weeks of taVNS application, the open field test (OFT) and elevated plus maze (EPM) were used to evaluate anxiety‐like behaviors, and the Y‐maze test and novel object recognition test (NORT) were used to evaluate recognition memory behaviors, respectively.ResultsWe found that repetitive taVNS was well tolerated by awake mice, had no effect on anxiety‐like behaviors, and significantly improved memory.ConclusionOur findings suggest that this new taVNS device for repetitive stimulation of awake mice is safe, tolerable, and effective.

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Locus coeruleus tyrosine hydroxylase positive neurons mediated the peripheral and central therapeutic effects of transcutaneous auricular vagus nerve stimulation (taVNS) in MRL/lpr mice

Cited by 4 publications

References 57 publications

Impact of optimized transcutaneous auricular vagus nerve stimulation on cardiac autonomic profile in healthy subjects and heart failure patients

Impact of optimized transcutaneous auricular vagus nerve stimulation on cardiac autonomic profile in healthy subjects and heart failure patients

Transcutaneous auricular vagus nerve stimulation as a novel therapy connecting the central and peripheral systems: a review

Feasibility and effectiveness of transcutaneous auricular vagus nerve stimulation (taVNS) in awake mice

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