Locust bean gum: Exploring its potential for biopharmaceutical applications

Dionísio, Marita; Grenha, Ana

doi:10.4103/0975-7406.99013

Cited by 133 publications

(25 citation statements)

References 92 publications

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“…Dionisio et al depicted in detail the applications of LBG in drug delivery [117]. Here, we present the new outcomes about formulations involving LBG solely or in combination with other polymers.…”

Section: Lbg As Carrier Agent For Controlled Release Of Drugsmentioning

confidence: 88%

“…Especially calixarenes possess structural features considered to be potential drug carriers (Drug Delivery Systems, DDS) due to their unlimited chemical modifications and their selective creation of complexes with biomolecules [120,121,122]. Carob fruit phytochemicals could be a potential candidate for formulations with calixarenes and cyclodextrins as a result of its extensive use in drug-delivery witnesses [9,11,117]. …”

Section: Future Directions—conclusionmentioning

confidence: 99%

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Functional Components of Carob Fruit: Linking the Chemical and Biological Space

Goulas

Stylos

Chatziathanasiadou

et al. 2016

IJMS

130

135

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The contribution of natural products to the drug-discovery pipeline has been remarkable since they have served as a rich source for drug development and discovery. Natural products have adapted, during the course of evolution, optimum chemical scaffolds against a wide variety of diseases, including cancer and diabetes. Advances in high-throughput screening assays, assisted by the continuous development on the instrumentation’s capabilities and omics, have resulted in charting a large chemical and biological space of drug-like compounds, originating from natural sources. Herein, we attempt to integrate the information on the chemical composition and the associated biological impact of carob fruit in regards to human health. The beneficial and health-promoting effects of carob along with the clinical trials and the drug formulations derived from carob’s natural components are presented in this review.

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Section: Lbg As Carrier Agent For Controlled Release Of Drugsmentioning

confidence: 88%

Section: Future Directions—conclusionmentioning

confidence: 99%

Functional Components of Carob Fruit: Linking the Chemical and Biological Space

Goulas

Stylos

Chatziathanasiadou

et al. 2016

IJMS

130

135

View full text Add to dashboard Cite

show abstract

“…Buccal, or in some cases nasal drug delivery, is an option for these types of medication. Both bucaal and nasal inserts have been formulated with (xanthan + locust bean gum) and (xanthan + guar gum) respectively [37,38]. The nasal inserts showed excellent bioadehesion and sustained drug release for a medication to reduce nausea and vomiting (metoclopromide hydrochloride) in the treatment of cancer chemotherapy, migraine, pregnancy and gastroparesis [38].…”

Section: Reviewmentioning

confidence: 99%

Thickening agents used for dysphagia management: effect on bioavailability of water, medication and feelings of satiety

Cichero

2013

Nutr J

212

140

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Dysphagia is the medical term for difficulty swallowing. Thickened liquids are often used in the management of dysphagia to improve bolus control and to help prevent aspiration. A range of starches and gums has historically been used to thicken liquids. Although thickened liquids improve swallow safety, they appear to have a great potential for unintended physiological consequences. Initial concerns were raised about the impact of thickeners on water binding due to the high prevalence of dehydration amongst individuals with dysphagia. Thankfully, regardless of thickening agent, thickeners do not affect water bioavailability. This effect holds true even for extremely thick fluids. However, bioavailability of medication is impaired with viscous substances. Liquids thickened to as little as 150 mPa.s retards drug release. In addition, feelings of satiety and thirst increase with increasingly viscous fluids. Flavour deteriorates with increasing thickness regardless of thickening agent. Therapeutically clinicians often prescribe small volumes of thickened liquids, consumed often. Yet small volumes of thick substances consumed with a long oral processing time, which is common for individuals with dysphagia, reduces the amount consumed. A combination of poor flavour, and increasing feelings of fullness result in little motivation and poor physiologic drive to consume thickened liquids.This review provides evidence from the dysphagia, pharmaceutical and food technology literature to show unintended side effects of thickened liquids that contribute to dehydration and potential sub-theraputic medication levels for individuals with dysphagia. The physical property of viscosity rather than a particular thickening agent appears to be key. Provision of “spoon-thick” or “extremely thick liquids” is particularly likely to contribute to dehydration and poor bioavailability of solid dose medication. Clinicians are encouraged to prescribe the minimal level of thickness needed for swallowing safety. Consultation with pharmacy and dietetic staff is essential for optimum management of individuals with dysphagia. Given the aged population forecasts for the year 2050, improved dysphagia management should be a high priority.

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“…55 Additionally, the β-mannanase and mannosidase secreted from the microflora in colon environment can degrade the hydrogel-based therapeutics and release the drug molecule from a galactomannan-based hydrogel. 56,57 The sequence analysis of bglC1 and gmuG (SL-1) genes of Bacillus sp. SL-1 showed 100.0% homology with both of these genes from B. licheniformis as well as 76.43% and 72.48% identities with those of B. subtilis 168, respectively.…”

Section: Pharmaceutically Important Enzymes From Halo-thermotolerant mentioning

confidence: 99%