Log odds of positive lymph nodes as a prognostic indicator in stage IV colorectal cancer patients undergoing curative resection

Ozawa, Tomohiro; Ishihara, Soichiro; Sunami, Eiji; Kitayama, Joji; Watanabe, Toshiaki

doi:10.1002/jso.23855

Cited by 15 publications

(25 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For this reason, it is intuitive that RLNs and the number of negative lymph nodes should be simultaneously taken into consideration when formulating an adjuvant treatment plan. LODDS is an intuitive indicator that is reflective of both interrogated lymph nodes and the number of negative lymph nodes, and its use is supported by available data in other malignancies [7, 9–11]. For the first time in the epithelial ovarian cancer population, we evaluated ROC curves based on RLNs, PLNs, LNR and LODDS, and found that LODDS has the highest AUC with superior sensitivity and specificity compared to other factors.…”

Section: Discussionmentioning

confidence: 94%

See 1 more Smart Citation

A novel nomogram based on LODDS to predict the prognosis of epithelial ovarian cancer

Cheng

Tang³

et al. 2016

Oncotarget

View full text Add to dashboard Cite

BACKGROUNDTo develop and validate a nomogram based on log of odds between the number of positive lymph node and the number of negative lymph node (LODDS) in predicting the overall survival (OS) and cancer specific survival (CSS) for epithelial ovarian cancer (EOC) patients.MATERIALS AND METHODSA total of 10,692 post-operative EOC patients diagnosed between 2004 and 2013 were obtained from the Surveillance, Epidemiology, and End Results (SEER) database and randomly divided into training (n = 7,021) and validation (n = 3,671) cohorts. Multiple clinical pathological parameters were assessed and compared with outcomes. Parameters significantly correlating with outcomes were used to build a nomogram. Bootstrap validation was subsequently used to assess the predictive value of the model.RESULTSIn the training set, age at diagnosis, race, marital status, tumor location, stage, grade and LODDS were correlated significantly with outcome in both the univariate and multivariate analyses and were used to develop a nomogram. The nomogram demonstrated good accuracy in predicting OS and CSS, with a bootstrap-corrected concordance index of 0.757 (95% CI, 0.746-0.768) for OS and 0.770 (95% CI, 0.759-0.782) for CSS. Notably, in this population our model performed favorably compared to the currently utilized Federation of Gynecology and Obstetrics (FIGO) model, with concordance indices of 0.699 (95% CI, 0.688-0.710, P < 0.05) and 0.719 (95% CI, 0.709- 0.730, P < 0.05) for OS and CSS, respectively. Using our nomogram in the validation cohort, the C-indices were 0.757 (95% CI, 0.741-0.773, P < 0.05, compared to FIGO) for OS and 0.762 (95% CI, 0.746-0.779, P < 0.05, compared to FIGO) for CSS.CONCLUSIONSLODDS works as an independent prognostic factor for predicting survival in patients with EOC regardless of the tumor stage. By incorporating LODDS, our nomogram may be superior to the currently utilized FIGO staging system in predicting OS and CSS among post-operative EOC patients.

show abstract

Section: Discussionmentioning

confidence: 94%

“…Recently, ratio of PLNs to RLNs (LNR) and log of odds between PLNs and the number of negative lymph node (LODDS) have emerged as alternative predictive factors for outcomes in breast [6, 7], gastric [8], pancreatic [9] and colorectal cancer [10, 11]. LNR is defined as the ratio of PLNs to RLNs.…”

Section: Introductionmentioning

confidence: 99%

A novel nomogram based on LODDS to predict the prognosis of epithelial ovarian cancer

Cheng

Tang³

et al. 2016

Oncotarget

View full text Add to dashboard Cite

show abstract

“…Median follow up was 16 months (range, 0-117 months). The median LNR was 0.25 (range, 0-0.94) and used a cutoff to define patients with a low LNR (L-LNR, ≤0.25) or high LNR (H-LNR, >0.25), as previously reported (8). Among 53 eligible patients, 26 (49%) had H-LNR.…”

Section: Resultsmentioning

confidence: 99%

“…Appropriate surgical technique along with diligent pathologic examination of resected specimen are required to consistently attain that goal (16,17). Due to variability in surgical technique and pathologic assessment of specimens, recent studies have proposed alternative LN parameters which may be more reliable than standard nodal staging in predicting outcomes (8,9). The most thoroughly investigated alternative nodal staging approach is LNR (18,19).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Association of primary tumor lymph node ratio with burden of liver metastases and survival in stage IV colorectal cancer

Ahmad¹,

Reha²,

Saied³

et al. 2017

Hepatobiliary Surg. Nutr.

View full text Add to dashboard Cite

Survival effect of different lymph node staging methods on ovarian cancer: An analysis of 10 878 patients

Wang

Chen

et al. 2018

Cancer Medicine

View full text Add to dashboard Cite

BackgroundTo compare the survival impact of several lymph node staging methods and therapeutic role of lymphadenectomy in patients with epithelial ovarian cancer who had undergone lymphadenectomy.MethodsData were retrospectively collected from the Surveillance, Epidemiology, and End Results program between 1988 and 2013.ResultsAn increasing number of resected lymph nodes (RLNs) was associated with a significant improvement in survival of FIGO stage II and III disease. However, for FIGO stage IV patients, better survival was not significantly associated with a more extensive lymphadenectomy. A higher lymph node ratio (LNR) and log odds of positive lymph nodes (LODDS) were associated with poorer survival regardless of stage. Nevertheless, four‐category classification of LODDS was more suitable for stage IV patients when three‐category classification was compatible with stage I‐III disease. Multivariate analysis demonstrated that LODDS and LNR were significant independent prognostic factors, but not RLN classification.ConclusionSixteen to thirty RLNs are recommended for stage I disease. For stages II and III patients, the more lymph node excision, the better the prognosis. However, lymphadenectomy was nonessential for stage IV patients. Considering staging methods, for stages II and III patients, three‐category classification of LODDS was recommended to evaluate the prognosis. For stage I and IV, three‐category classification of positive LNR was idoneous.

show abstract

Log odds of positive lymph nodes as a prognostic indicator in stage IV colorectal cancer patients undergoing curative resection

Abstract: The LODDS is a good prognostic indicator in Stage IV CRC patients who have undergone curative resection.

Cited by 15 publications

References 36 publications

A novel nomogram based on LODDS to predict the prognosis of epithelial ovarian cancer

A novel nomogram based on LODDS to predict the prognosis of epithelial ovarian cancer

Association of primary tumor lymph node ratio with burden of liver metastases and survival in stage IV colorectal cancer

Survival effect of different lymph node staging methods on ovarian cancer: An analysis of 10 878 patients

Contact Info

Product

Resources

About