Loganin attenuates diabetic nephropathy in C57BL/6J mice with diabetes induced by streptozotocin and fed with diets containing high level of advanced glycation end products

Loganin possesses neuroprotective properties, restores SMN protein and activates protein synthesis positive regulator Akt/mTOR in experimental models of spinal muscular atrophy

“…Loganin has been mentioned for its glucose-lowering effect [27] and anti-diabetic nephropathic activity [31][32][33][34], but this study has first reported the potential muscle protective effect of loganin. In SMA, despite the above-mentioned beneficial effects of loganin such as SMN restoration and neuroprotection, the potential muscle protection of loganin via regulating two major protein synthesis pathways, a positive regulator Akt/mTOR pathway and a negative regulator atrogin-1/MuRF-1 pathway were also revealed in this study.…”

“…Loganin has been mentioned for its glucose-lowering effect [27] and anti-diabetic nephropathy activity [31][32][33][34]; however, the protective effects and mechanisms of loganin on SMN-deficient neuron and atrophic muscle are firstly investigated here. In the present study, the effects of loganin on SMA were investigated in a severe SMA animal model, SMA7 mice and in two cellular models of SMA, SMN-deficient motor neuron-like NSC34 cells and skin fibroblasts from SMA patients.…”

Iridoids are natural glycation inhibitors

“…Loganin also increased serum and k i d n e y S O D a n d d e c r e a s e d s e r u m a n d k i d n e y malondialdehyde. These changes were associated with improved diabetic symptoms in the mice [119].…”

Therapeutic Insights against Oxidative Stress Induced Diabetic Nephropathy: A Review

“…It is necessary to timely scavenge these free radicals otherwise persistent exposure to them can lead to tissue degradation directing its way to a state of organ pathophysiology. To prevent the deleterious effects of free radicals, the effects of antioxidants are extensively studied [83][84][85][86]. Antioxidants act through different mechanisms at various sites exerting a number of biochemical effects.…”