Background: Diabetes has significant effects on bone metabolism. Both type 1 and type 2 diabetes can cause osteoporotic fracture. However, it remains challenging to diagnose osteoporosis in type 2 diabetes by bone mineral density which lacks regular changes. Seen another way, osteoporosis can be ascribed to the imbalance of bone metabolism, which is closely related to diabetes as well. Method: Here, to assist clinicians in diagnosing osteoporosis in type 2 diabetes, an efficient and simple SVM model was established based on different combinations of biochemical indices, including bone turnover makers, calcium and phosphorus, etc. The classification performance was measured using several evaluations. Results: The predicting accuracy rate of final model is above 88%, with feature combination of Sex, Age, BMI, TP1NP and OSTEOC. Conclusion: Experimental results show that the model has come to an anticipant result for early detection and daily monitoring on type 2 diabetic osteoporosis.