Logistic Analysis of Risk Factors in Acute Retinopathy of Prematurity

Retinopathy of prematurity in babies weighing <1800 g; with special reference to babies weighing between 1501 and 1800 g: An experience from a tertiary care hospital in Delhi

“…Similarly, babies given extensive resuscitation with low APGAR scores <3 at 5 min had a signifi cantly increased incidence of ROP due to virtue of tissue hypoxia and acidosis. Similar results were found in the studies done by Hammer et al [20] The present study found PDA to be a signifi cant risk factor in the causation of ROP in babies owing to increased delivery of oxygen to tissues; similar fi nding was endorsed by the studies done in Indian context [18] and western context. [20,21] Use of vasopressors was associated with increased risk of ROP due to vasoconstriction and tissue anoxia on the univariate analysis.…”

“…Similar results were found in the studies done by Hammer et al [20] The present study found PDA to be a signifi cant risk factor in the causation of ROP in babies owing to increased delivery of oxygen to tissues; similar fi nding was endorsed by the studies done in Indian context [18] and western context. [20,21] Use of vasopressors was associated with increased risk of ROP due to vasoconstriction and tissue anoxia on the univariate analysis. Liu et al [22] and Nair et al [24] found use of dopamine to be signifi cantly associated with ROP; both on univariate and logistic regression analysis.…”

“…[16,18,23] MV due to variation in the oxygen tension was implicated as a risk factor; which is in accordance with various studies done by Yanovitch et al [17] and Dogra et al [16] MV was found to be independent risk factor in the causation of ROP [Table 3a] in infants weighing ≤1800 g. Similar fi nding was replicated by Yanovitch et al, [17] Dogra et al; [16] though on univariate analysis in babies weighing 1250-1800 g. Our present study of infants weighing ≤1800 g established a strong statistical association of BTs (P < 0.0001); similar to the studies done in the western context [17] and Indian context. [16,19] This study found anemia to be a signifi cant risk factor, which is in concordance with the study done by Hammer et al, [20] in which 37 out of 137 infants with anemia developed ROP. IUGR in the present study came out to be signifi cant and had a protective infl uence on ROP However, study done by Prendville et al [21] in 144 infants failed to fi nd a signifi cant co-relation between IUGR babies and ROP.…”

“…[17] RDS may result due to variations in oxygen fl uctuation, alternating hypoxia, and hypercarbia; leading to ROP, which is in concordance with various studies done in Indian [19] and the western world. [20,21] The incidence of ROP was directly proportional to the length of time the tissue remains in acidotic state; these fi ndings were concordant with data obtained in western [20,21] and Indian context. [16,18,23] MV due to variation in the oxygen tension was implicated as a risk factor; which is in accordance with various studies done by Yanovitch et al [17] and Dogra et al [16] MV was found to be independent risk factor in the causation of ROP [Table 3a] in infants weighing ≤1800 g. Similar fi nding was replicated by Yanovitch et al, [17] Dogra et al; [16] though on univariate analysis in babies weighing 1250-1800 g. Our present study of infants weighing ≤1800 g established a strong statistical association of BTs (P < 0.0001); similar to the studies done in the western context [17] and Indian context.…”

Retinal dysplasia in mice lacking p56lck

“…In our model, the lack of Lck protein resulted in retinal injury similar to that of ROP frequently seen in human infants and to that resulting from a photosensitization mechanism by which oxygen and light can interact to produce oxygen-derived free radicals, such as superoxide. ROP is a multifactorial disease and numerous risk factors in addition to light and oxygen such as xanthine administration, vitamin E de®ciency, gestational agebirth weight (Zierler 1988;Hammer et al, 1986;Sira et al, 1985) have been reported. A number of these suggested risk factors are consistent with an oxidative mechanism of injury; the lack of su cient antioxydant, such as vitamin E (Penn et al, 1992), would be expected to exacerbate the severity of oxidative retinal damage.…”