Logopenic aphasia or Alzheimer's disease: Different phases of the same disease?

Beber, Bárbara Costa; Kochhann, Renata; Silva, Bruna Matias da; Chaves, Márcia Lorena Fagundes

doi:10.1590/s1980-57642014dn83000016

Cited by 9 publications

(6 citation statements)

References 26 publications

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“…The lack of histopathologic examination precluded the establishment of a final diagnosis in our case. The lvPPA is more commonly associated with Alzheimer’s pathology [ 29 ], which might explain the difficulty to differentiate Alzheimer’s disease from lvPPA in certain cases [ 30 ]. Given the similarity of our case to the pattern of semantic dementia from right temporal variant frontotemporal dementia (tvFTD), TDP-43 pathology should also be considered [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

A presumptive association between obsessive compulsions and asymmetric temporal lobe atrophy: a case report

et al. 2022

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Background The relatively isolated atrophy of the temporal lobes leads to a clinical radiological pattern, referred to as the temporal variant of frontotemporal dementia. While semantic dementia and behavioral variant frontotemporal dementia are classically related to this syndrome, the logopenic variant of primary progressive aphasia has been less commonly reported. This case report aims to give a pictorial description of a case in which a patient with asymmetric temporal lobe atrophy presented with the logopenic variant of primary progressive aphasia and complex rituals of cleanliness. Case presentation We report on the case of a 68-year-old, right-handed White woman with complex rituals and progressive speech impairment. The obsessive–compulsive rituals represented an exacerbation of lifelong preoccupations with cleanliness and orderliness that were praised by her relatives. Neuropsychological assessment revealed a striking impairment of language and memory, with relative sparing of tool-use praxis and visuospatial skills. Magnetic resonance imaging and 18fluorodeoxyglucose-positron emission tomography scans showed bilateral asymmetrical temporal lobe atrophy and hypometabolism. A year later, she was still able to entertain conversation for a short while, but her vocabulary and fluency had further declined. Praxis and visuospatial skills remained intact. She did not experience pathological elation, delusions, or hallucinations. The disease followed a relentless progression into a partial Klüver–Bucy syndrome, abulia, and terminal dementia. She died from acute myocardial infarction 8 years after the onset of aphasia. The symptoms and their temporal course supported a diagnosis of logopenic variant of primary progressive aphasia due to asymmetric temporal variant frontotemporal lobar degeneration. Conclusions This report gives a pictorial description of a temporal variant of frontotemporal dementia in a patient who presented with worsening of a lifelong obsessive–compulsive disorder and logopenic variant of primary progressive aphasia.

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Section: Discussionmentioning

confidence: 99%

A presumptive association between obsessive compulsions and asymmetric temporal lobe atrophy: a case report

et al. 2022

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“…We only use the three sub-types of FTD in NIFD dataset: bvFTD, PNFA and SV. The reason for this is that the other variant of FTD (i.e., logopenic variant) is typically associated with AD neuropathological changes [23,24]. Finally, only subjects with consistent diagnosis thorough their follow-up sessions are included in this study.…”

Section: Datasetsmentioning

confidence: 99%

Interpretable Differential Diagnosis for Alzheimer’s Disease and Frontotemporal Dementia

Nguyen

Clément

Mansencal

et al. 2022

Lecture Notes in Computer Science

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Alzheimer's disease and Frontotemporal dementia are common forms of neurodegenerative dementia. Behavioral alterations and cognitive impairments are found in the clinical courses of both diseases and their differential diagnosis is sometimes difficult for physicians. Therefore, an accurate tool dedicated to this diagnostic challenge can be valuable in clinical practice. However, current structural imaging methods mainly focus on the detection of each disease but rarely on their differential diagnosis. In this paper, we propose a deep learning based approach for both problems of disease detection and differential diagnosis. We suggest utilizing two types of biomarkers for this application: structure grading and structure atrophy. First, we propose to train a large ensemble of 3D U-Nets to locally determine the anatomical patterns of healthy people, patients with Alzheimer's disease and patients with Frontotemporal dementia using structural MRI as input. The output of the ensemble is a 2-channel disease's coordinate map able to be transformed into a 3D grading map which is easy to interpret for clinicians. This 2channel map is coupled with a multi-layer perceptron classifier for different classification tasks. Second, we propose to combine our deep learning framework with a traditional machine learning strategy based on volume to improve the model discriminative capacity and robustness. After both cross-validation and external validation, our experiments based on 3319 MRI demonstrated competitive results of our method compared to the state-of-the-art methods for both disease detection and differential diagnosis.

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“…Cette recension comporte une étude de cas [13] et 18 études de groupes comportant entre 14 et 155 participants atteints d'un trouble neurodégénératif [8,[14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30]. Au total, 880 participants présentant un syndrome d'APP sont inclus dans cette recension (307 vlAPP, 145 vsAPP, 212 vnf/aAPP, 96 APP mixtes/non classées.…”

Section: Caractéristiques Principales Des éTudesunclassified

“…Au total, 880 participants présentant un syndrome d'APP sont inclus dans cette recension (307 vlAPP, 145 vsAPP, 212 vnf/aAPP, 96 APP mixtes/non classées. Elle porte également sur 20 personnes présentant un déficit cognitif léger [24] et 100 personnes ayant rec ¸u un diagnostic de MA syndromique (n = 68) [13,17,22,24,26] ou étiologique (i.e. confirmé par autopsie, n = 27 ; ou par modification des biomarqueurs spécifiques de la MA, n = 5) [8,14].…”

Section: Caractéristiques Principales Des éTudesunclassified

“…Dans cinq des 19 articles, les auteurs dressent un inventaire des différences cliniques entre la MA classique et la vlAPP [14,17,22,24,26]. Deux autres études [8,13] la différenciation entre la vlAPP et la MA. Finalement, deux études [25,28] remettent directement en question l'existence même de la vlAPP au moyen d'analyses factorielles.…”

Section: Caractéristiques Principales Des éTudesunclassified

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La variante logopénique de l’aphasie primaire progressive : état des connaissances et controverses cliniques

Marceau¹,

Veilleux-Létourneau²,

Macoir³

2018

Revue De Neuropsychologie

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Logopenic aphasia or Alzheimer's disease: Different phases of the same disease?

Cited by 9 publications

References 26 publications

A presumptive association between obsessive compulsions and asymmetric temporal lobe atrophy: a case report

A presumptive association between obsessive compulsions and asymmetric temporal lobe atrophy: a case report

Interpretable Differential Diagnosis for Alzheimer’s Disease and Frontotemporal Dementia

La variante logopénique de l’aphasie primaire progressive : état des connaissances et controverses cliniques

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