Lokale Wundtherapie eines chronischen therapierefraktären Ulcus cruris venosum mit Omega3-Wundmatrix

Cyrek, A.; Bernheim, Jan L.; Juntermanns, Benjamin; Paúl, Alexandra

doi:10.12687/phleb2387-6-2017

Cited by 5 publications

(5 citation statements)

References 18 publications

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“…No adverse reactions have been observed during clinical use of the fish skin grafts. [26][27][28] Healthy volunteers with fullthickness skin wounds that were treated with the fish skin grafts showed no elevations of anti-type I collagen or antitype II collagen antibodies. 29 The detection of anti-type II collagen antibodies in the porcine collagen group was unexpected.…”

Section: Discussionmentioning

confidence: 99%

Acellular Fish Skin Grafts and Pig Urinary Bladder Matrix Assessed in the Collagen-Induced Arthritis Mouse Model

Magnússon

Kjartansson

Baldursson

et al. 2018

The International Journal of Lower Extremity Wounds

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Basic and Experimental Science Cellular-and tissue-based products (CTPs) are used in the treatment of wounds of various etiologies. 1-3 CTPs are typically decellularized and virally inactivated, leaving behind the structural elements of connective tissue, mainly collagens. Most CTPs are composed of type I collagen, but some CTPs also contain other collagen types. One CTP example is porcine urinary bladder matrix that contains numerous collagens. 4 The majority of contemporary CTPs are mammalian in origin. Concerns exist regarding collagen's potential to provoke autoimmune responses. 5-10 In addition to possible autoimmune responses, other disadvantages associated with mammalian-derived matrices are the potential of transmission of prion and viral diseases such as bovine spongiform encephalopathy, 11 as well as cultural and religious objections. 12,13 Fish skin grafts from the Atlantic cod (Gadus morhua) do not pose a risk of disease transmission as do mammalian CTPs. 14 Because of the use of fish skin products in the food industry, there is an abundance of studies on the specific allergens contained in fish skin and on the composition of extracted collagens. 15-17 The introduction of foreign proteins in a test subject can trigger an immune system response that normally results in the transient production of antibodies. The induction of an

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Section: Discussionmentioning

confidence: 99%

Acellular Fish Skin Grafts and Pig Urinary Bladder Matrix Assessed in the Collagen-Induced Arthritis Mouse Model

Magnússon

Kjartansson

Baldursson

et al. 2018

The International Journal of Lower Extremity Wounds

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“…Apart from NF therapy, iFSGs have already been used in a broad spectrum of clinical situations. Typical and commonly reported indications for iFSGs involve chronic wounds caused by peripheral arterial occlusive disease, chronic venous insufficiency or diabetes mellitus [ 15 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 38 ]. These reports also describe its successful use in uncovered tendons or bones, as in our second patient.…”

Section: Discussion and Literature Reviewmentioning

confidence: 99%

“…Vasculitis (MPO (myeloperoxidase), p-ANCA, cryo-positive) of small, medium and large vessels in the setting of undifferentiated collagenosis [15]; • Ischemic necrosis (sepsis-related, dialysis shunt-associated steal syndrome) [15]; • Necrotic angiodermatitis [35]; • Calciphylaxis [34]; • Hemophilia-associated chronic wound [33]. Burns Partial thickness burns [24,29,32]; • Full-thickness burns and blast areas [38]; • Thin-skin graft donor site [29][30][31].…”

Section: Atypical Wounds •mentioning

confidence: 99%

The Use of Intact Fish Skin Grafts in the Treatment of Necrotizing Fasciitis of the Leg: Early Clinical Experience and Literature Review on Indications for Intact Fish Skin Grafts

Dueppers,

Bozalka,

Kopp

et al. 2023

JCM

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Background: Necrotizing fasciitis (NF) is a serious infectious disease that can initially place the patient’s life in danger and, after successful surgical and antibiotic treatment, leaves extensive wounds with sometimes even exposed bones and tendons. Autologous skin grafts are not always possible or require adequate wound bed preparation. Novel intact fish skin grafts (iFSGs; Kerecis® Omega3 Wound, Kerecis hf, Isafjördur, Iceland) have already shown their potential to promote granulation in many other wound situations. Faster wound healing rates and better functional and cosmetic outcomes were observed due to their additionally postulated anti-inflammatory and analgesic properties. Therefore, iFSGs may also be essential in treating NF. We present our initial experience with iFSGs in treating leg wounds after NF and review the literature for the current spectrum of clinical use of iFSGs. Case Presentations: We present two male patients (aged 60 and 69 years) with chronic or acute postsurgical extensive leg ulcers six weeks and six days after necrotizing fasciitis, respectively. Both suffered from diabetes mellitus without vascular pathologies of the lower limbs. A single application of one pre-meshed (Kerecis® Graftguide) and one self-meshed 300 cm2 iFSG (Kerecis® Surgiclose) was performed in our operation room after extensive surgical debridement and single circles of negative wound pressure therapy. Application and handling were easy. An excellent wound granulation was observed, even in uncovered tibia bone and tendons, accompanied by pain relief in both patients. Neither complications nor allergic reactions occurred. The patients received autologous skin grafting with excellent functional and cosmetic outcomes. Conclusions: iFSGs have the potential to play a significant role in the future treatment of NF due to the fast promotion of wound granulation and pain relief. Our experience may encourage surgeons to use iFSGs in NF patients, although high-quality, large-sized studies are still required to confirm these results. The observed effects of iFSGs on wounds associated with NF may be transferred to other wound etiologies as well.

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“…Previous studies have already explored the potential of Kerecis ® fish skin in hard-to-heal lower extremity chronic ulcers and deep-burn management [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ]. Despite its demonstrated efficacy, the pediatric field in this matter is poorly documented [ 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Place of Fish Skin Grafts with Omega-3 in Pediatric Wound Management

Cherry,

Tarhini,

Doan

et al. 2023

JCM

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Wound healing in the pediatric population is known to be a challenge and poorly studied. Split-thickness skin grafts, full-thickness skin grafts, and flaps overlap their applications with the growing field of cellular and tissue-based therapies. However, their role in pediatric reconstruction has yet to be defined. The Kerecis® Omega-3 wound patch, derived from decellularized codfish skin, has garnered attention due to its preserved microscopic architecture resembling the human extracellular matrix. This acellular dermal matrix acts as a scaffold, fostering dermal cell and capillary adhesion while harnessing omega-3 polyunsaturated fatty acids for granulation acceleration and antimicrobial effects. This study presents a comprehensive review and surgical protocol for utilizing Kerecis® fish skin in pediatric wound care. The research embraces a case series involving five patients with diverse wound locations. The Kerecis® Omega-3 wound patch underwent meticulous application and careful monitoring. The results highlight an average time of 48.6 days for complete epithelialization, yielding favorable outcomes with no hypertrophic scarring and mild retraction. Kerecis® fish skin grafting stands as a tool that not only accelerates healing but also addresses the multifaceted challenges associated with wound management in the pediatric population: the avoidance of donor site morbidity and improved postoperative pain control.

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Lokale Wundtherapie eines chronischen therapierefraktären Ulcus cruris venosum mit Omega3-Wundmatrix

Cited by 5 publications

References 18 publications

Acellular Fish Skin Grafts and Pig Urinary Bladder Matrix Assessed in the Collagen-Induced Arthritis Mouse Model

Acellular Fish Skin Grafts and Pig Urinary Bladder Matrix Assessed in the Collagen-Induced Arthritis Mouse Model

The Use of Intact Fish Skin Grafts in the Treatment of Necrotizing Fasciitis of the Leg: Early Clinical Experience and Literature Review on Indications for Intact Fish Skin Grafts

Exploring the Place of Fish Skin Grafts with Omega-3 in Pediatric Wound Management

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