Long-acting FSH versus daily FSH for women undergoing assisted reproduction

Pouwer, Anne-Floor W.; Farquhar, Cindy; Kremer, J.A.M.

doi:10.1002/14651858.cd009577.pub3

Cited by 48 publications

(19 citation statements)

References 39 publications

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“…However, in rodents, the injection of these FSH isoforms exhibited different pharmacokinetics, due to the clearance operated by different metabolic pathways, depending on the type of glycan linked to the hormones [80]. To overcome the relatively short half-life of FSH, which requires daily administration, a new recombinant molecule with a prolonged action was produced in transfected CHO cells [81], corifollitropin alpha (Elonva ® ; MSD, Readington, NJ, USA). This chimeric molecule includes the sequence encoding the CTP extension of hCGβ fused to the human FSHβ subunit, which bears four O-linked glycosylation sites and provides extended half-life [82,83].…”

Section: Fsh In Therapymentioning

confidence: 99%

FSH for the Treatment of Male Infertility

Casarini

Crépieux

Reiter

et al. 2020

IJMS

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Follicle-stimulating hormone (FSH) supports spermatogenesis acting via its receptor (FSHR), which activates trophic effects in gonadal Sertoli cells. These pathways are targeted by hormonal drugs used for clinical treatment of infertile men, mainly belonging to sub-groups defined as hypogonadotropic hypogonadism or idiopathic infertility. While, in the first case, fertility may be efficiently restored by specific treatments, such as pulsatile gonadotropin releasing hormone (GnRH) or choriogonadotropin (hCG) alone or in combination with FSH, less is known about the efficacy of FSH in supporting the treatment of male idiopathic infertility. This review focuses on the role of FSH in the clinical approach to male reproduction, addressing the state-of-the-art from the little data available and discussing the pharmacological evidence. New compounds, such as allosteric ligands, dually active, chimeric gonadotropins and immunoglobulins, may represent interesting avenues for future personalized, pharmacological approaches to male infertility.

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Section: Fsh In Therapymentioning

confidence: 99%

FSH for the Treatment of Male Infertility

Casarini

Crépieux

Reiter

et al. 2020

IJMS

View full text Add to dashboard Cite

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“…They have rarely been associated with OHSS [10]. Most infertility regimens use daily FSH injections for follicular stimulation [11]. FSH is used in conjunction with a low dose of a GnRH analog to prevent the LH surge until the follicles are judged to be mature.…”

Section: Controlled Ovarian Stimulationmentioning

confidence: 99%

A Brief Review of Stroke associated with Assisted Reproductive Technology

O’Neal¹

2017

J Neurol Neurophysiol

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Strokes related to assisted reproductive technology are rare, but can be devastating. In order to understand how stroke can occur as a complication of assisted reproductive technology, both the normal physiology of ovulation and the hormonal manipulations used to maximize pregnancy will be examined. In particular, the danger of thrombotic complications related to ovarian hyperstimulation syndrome will be reviewed including the pathophysiology, clinical features, risk factors and treatment.

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“…Randomized controlled trials comparing gonadotropin preparations have primarily focused on clinical aspects and have been designed to evaluate the number of oocytes retrieved or, to a lesser extent, pregnancy rates. [6][7][8][9] Several studies comparing the outcome of r-FSH and hMG have been reported, most of which were performed in women undergoing pituitary downregulation with a GnRH agonist long protocol. [10][11][12][13] Recent meta analysis have demonstrated that hMG was not inferior to r-FSH with regard to pregnancy and live birth rates.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Human Menopousal Gonadotropin with Recombinant Follicle Stimulating Hormone in Ovulation Stimulation During Intrauterine Insemination

Hartono¹

2016

AJCEM

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Fecundability increases when ovulation induction was conducted before starting intrauterine insemination procedure (IUI). Human Menopousal gonadotrophin (HMG) and recombinant follicle stimulating hormone (rFSH) are gonadotropin hormones that are widely used in the stimulation of ovulation in infertile patients. Although comparison of gonadotropin preparations have been carried out in IVF, but comparison of rFSH preparations and HMG on IUI was still lacking. The aim of this study was to compare rFSH and HMG, each was combined with clomiphene citrate in infertile women undergone intrauterine insemination (IUI). This study was a retrospective study in the Department of Obstetrics and Gynecology Wahidin Sudirohusodo. Samples were infertile patients who meet these following criteria: women aged 20-45 years, infertility of unknown cause for approximately 12 months, had a history of induced ovulation for approximately 6 cycles without IUI, IVF or ICSI, patent tubes examined with hysterosalpingography, and normal semen analysis according to 1999 WHO criteria. A total of 78 patients consisted of 30 patients using clomiphene citrate + rFSH and 48 other patients using clomiphene citrate + HMG. In two groups, total dosage, duration of gonadotropin administration, follicle count, mean size of follicles, endometrial line size and pregnancy were compared. Statistical test using Levene T and unpaired t test was conducted using SPSS 16 for Windows version. There was no statistically significant difference among total dosage, duration of gonadotropins administration, follicle counts, mean size of follicles, and endometrial line size. The mean number of pregnancy was higher in patients treated with clomiphene citrate + hMG but this difference was not statistically significant. hMG and rFSH was equally effective in stimulating ovulation in intrauterine insemination.

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Long-acting FSH versus daily FSH for women undergoing assisted reproduction

Cited by 48 publications

References 39 publications

FSH for the Treatment of Male Infertility

FSH for the Treatment of Male Infertility

A Brief Review of Stroke associated with Assisted Reproductive Technology

Comparison of Human Menopousal Gonadotropin with Recombinant Follicle Stimulating Hormone in Ovulation Stimulation During Intrauterine Insemination

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