Long-acting inhalable chitosan-coated poly(lactic-co-glycolic acid) nanoparticles containing hydrophobically modified exendin-4 for treating type 2 diabetes

Lee, Changkyu; Choi, Ji Su; Kim, In-Soo; Oh, Kyung Taek; Lee, Eun Seong; Park, Eun-Seok; Lee, Kang Choon; Youn, Yu Seok

doi:10.2147/ijn.s48197

Cited by 24 publications

(7 citation statements)

References 33 publications

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“…PLGA nanoparticles coated with glycol chitosan was shown to be more readily absorbed onto A549 cells than the non-coated PLGA nanoparticles. The chitosan-coated PLGA nanoparticles were found in the lungs up to 72 h after pulmonary administration, whereas non-coated PLGA nanoparticles were removed from the lungs 8 h after administration [132].…”

Section: Drug Deliverymentioning

confidence: 99%

Delivery of natural phenolic compounds for the potential treatment of lung cancer

et al. 2019

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The application of natural products to treat various diseases, such as cancer, has been an important area of research for many years. Several phytochemicals have demonstrated anticarcinogenic activity to prevent or reduce the progression of cancer by modulating various cellular mechanisms. However, poor bioavailability has hindered clinical success and the incorporation of these drugs into efficient drug delivery systems would be beneficial. For lung cancer, local delivery via the pulmonary route would also be more effective. In this article, recent in vitro scientific literature on phenolic compounds with anticancer activity towards lung cancer cell lines is reviewed and nanoparticulate delivery is mentioned as a possible solution to the problem of bioavailability. The first part of the review will explore the different classes of natural phenolic compounds and discuss recent reports on their activity on lung cancer cells. Then, the problem of the poor bioavailability of phenolic compounds will be explored, followed by a summary of recent advances in improving the efficacy of these phenolic compounds using nanoparticulate drug delivery systems. Graphical abstract The rationale for direct delivery of phenolic compounds loaded in microparticles to the lungs

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Section: Drug Deliverymentioning

confidence: 99%

Delivery of natural phenolic compounds for the potential treatment of lung cancer

et al. 2019

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“…Smaller size relative to microspheres renders polymeric NPs a suitable drug carrier for parenteral administration. Moreover, it has been generally observed that NPs can translocate efficiently across epithelial surfaces relative to microparticles [5, 6]. Polymeric NPs also exhibit high stability in biological fluids compared to liposomes and solid lipid NPs.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Protein and Peptide Drug Delivery: A Special Emphasis on Polymeric Nanoparticles

Patel¹,

Patel²,

Yang³

et al. 2014

PPL

171

101

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Proteins and peptides are widely indicated in many diseased states. Parenteral route is the most commonly employed method of administration for therapeutic proteins and peptides. However, requirement of frequent injections due to short in vivo half-life results in poor patient compliance. Non-invasive drug delivery routes such as nasal, transdermal, pulmonary, and oral offer several advantages over parenteral administration. Intrinsic physicochemical properties and low permeability across biological membrane limit protein delivery via non-invasive routes. One of the strategies to improve protein and peptide absorption is by delivering through nanostructured delivery carriers. Among nanocarriers, polymeric nanoparticles (NPs) have demonstrated significant advantages over other delivery systems. This article summarizes the application of polymeric NPs for protein and peptide drug delivery following oral, nasal, pulmonary, parenteral, transdermal, and ocular administrations.

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“…ECM proteins induce migration and proliferation of cells (Badylak et al, 2001;Sarikaya et al, 2002). Nanoparticles formed from liposomes (Roursgaard et al, 2016), dendrimers (Kafil & Omidi, 2011), and PLGA (Lee et al, 2013) are toxic when given at similar concentrations to the same A549 cells. Proliferation of epithelial cells is important in COPD, as apoptosis of epithelial cells continues even after smoking cessation (Hodge, Hodge, Holmes, & Reynolds, 2005).…”

Section: Resultsmentioning

confidence: 99%

Electrosprayed extracellular matrix nanoparticles induce a pro‐regenerative cell response

Link

Ritchie

Cotman

et al. 2018

J Tissue Eng Regen Med

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Decellularized extracellular matrix (ECM) is an effective tissue repair scaffold. Additionally, ECM has recently been shown to be protective to the lungs. However, current processing is inadequate for effective delivery of ECM to the lungs. Processing methods, such as milling, produce large variability in particle sizes. The size variation produced is ineffective at treating the lung because only a small range of sizes reach the distal regions of the alveoli. The aim of this work is to formulate decellularized ECM to reach the distal lung while retaining the pro-regenerative effects of ECM.We first digested the protein in acid and then electrosprayed the solution into nanoparticles. The average size of the nanoparticles was 225 (±67) nm, within size requirements to reach the alveoli. After characterizing the particles, we measured cytotoxicity of the nanoparticles. Adding 0.125 mg/ml of nanoparticles to the media increased cellular proliferation in A549 alveolar epithelial cells and caused no cytotoxicity in BEAS-2B cells. We added the formed nanoparticles to macrophages derived from murine bone marrow-derived monocytes. The macrophages exposed to the formed nanoparticles expressed cell surface marker CD206 (mannose receptor C type 1), commonly attributed to a pro-regeneration phenotype. Electrosprayed ECM formed nanoparticles may improve bronchoalveolar deposition while maintaining the pro-regenerative benefits shown by other decellularized ECM materials.

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Long-acting inhalable chitosan-coated poly(lactic-co-glycolic acid) nanoparticles containing hydrophobically modified exendin-4 for treating type 2 diabetes

Cited by 24 publications

References 33 publications

Delivery of natural phenolic compounds for the potential treatment of lung cancer

Delivery of natural phenolic compounds for the potential treatment of lung cancer

Recent Advances in Protein and Peptide Drug Delivery: A Special Emphasis on Polymeric Nanoparticles

Electrosprayed extracellular matrix nanoparticles induce a pro‐regenerative cell response

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