Long-Acting, Injectable Antiretroviral Therapy for the Management of HIV Infection: An Update on a Potential Game-Changer

Barnhart, L.

doi:10.4172/2155-6113.1000466

Cited by 3 publications

(1 citation statement)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Long-acting injectable (LAI)-PrEP, formulated for multi-month use, was developed to overcome some of the challenges associated with oral PrEP. It offers numerous bene ts, including being discreet and less stigmatising, making it a potential alternative to oral PrEP (14). LAI-PrEP was safe and preferred over oral PrEP in the HPTN 083 trial, resulting in 66% fewer HIV infections among cisgender men and MSM (15).…”

Section: Introductionmentioning

confidence: 99%

Willingness to Use Long-acting Injectable Pre-exposure Prophylaxis Among Key Populations at a Large Hiv Prevention Clinic in Kampala, Uganda: a Cross-sectional Study

Lukubuya,

Katana,

Baguma

et al. 2024

Preprint

View full text Add to dashboard Cite

Background. Long-acting injectable (LAI)-PrEP provides better protection against HIV compared to oral PrEP, which requires taking a daily pill. Our study aimed to assess knowledge about oral and LAI-PrEP and identify factors associated with willingness to use LAI-PrEP among key populations (KP) in Uganda. Methods. We conducted a cross-sectional study at the Most at Risk Populations Initiative (MARPI) clinic between November and December 2021. Participants were recruited through convenience sampling and interviewed using a structured questionnaire by trained interviewers. Participants were categorised into three groups based on their oral PrEP use: those who had not yet initiated PrEP, those who had discontinued oral PrEP, and those currently on oral PrEP. Modified Poisson regression analysis was performed to determine factors associated with the participant's willingness to use LAI-PrEP. Data was analysed using STATA 14 software. Results. Of the 234 participants, 135 (56.7%) were female, 82.5% knew about LAI-PrEP, and 67.5% were willing to use it. The mean age was 28.7 years (standard deviation [SD] 5.8). Willingness to use LAI-PrEP was less likely among divorced, widowed, or separated individuals than those in relationships (adjusted prevalence ratio [aPR] 0.65, 95% CI: 0.43–0.98). Relative to current oral PrEP users, willingness to use LAI-PrEP was similar among those who discontinued oral PrEP (aPR 1.39, 95% CI: 0.92–2.11) and those who had not yet initiated PrEP but were at risk for HIV (aPR 1.26, 95% CI: 0.83–1.89). Conclusions. In this cross-sectional analysis of diverse members of key populations in Uganda, previous or non-use of oral PrEP was not associated with willingness to use LAI-PrEP relative to current users. Future studies should investigate effective methods for promoting the uptake of long-acting PrEP formulations among populations at high risk of HIV acquisition.

show abstract

Section: Introductionmentioning

confidence: 99%

Willingness to Use Long-acting Injectable Pre-exposure Prophylaxis Among Key Populations at a Large Hiv Prevention Clinic in Kampala, Uganda: a Cross-sectional Study

Lukubuya,

Katana,

Baguma

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

The LAIs Are Coming! Implementation Science Considerations for Long-Acting Injectable Antiretroviral Therapy in the United States: A Scoping Review

Kanazawa

Saberi

Sauceda

et al. 2021

AIDS Research and Human Retroviruses

View full text Add to dashboard Cite

Predictors and Barriers Associated with Non-Adherence to ART by People Living with HIV and AIDS in a Selected Local Municipality of Limpopo Province, South Africa

Nhlongolwane,

Shonisani

2023

TOAIDJ

View full text Add to dashboard Cite

Introduction: The partial success of Anti-Retroviral treatment remains a challenge, therefore, contributory factors need to be addressed for treatment success. For instance, issues leading to ART non-adherence, that can be prevented, must be identified and addressed. Prevention of HIV has remained the best approach to controlling the spread of HIV, as there is no definitive cure yet. This study aimed at identifying predictors and barriers associated with ART non-adherence amongst HIV patients attending an adult antiretroviral clinic in Makhado Municipality, Limpopo Province, South Africa Methods: A cross-sectional study was conducted with patients who were on antiretroviral treatment, were attending HIV and AIDS clinics, and whose ages ranged from 18 years and above; structured questionnaires were distributed to these respondents. Results: A total of 225 respondents participated in the study. There were more female (68%) respondents; most respondents (72%) were unemployed. They travelled more than 15 km to the treatment centers and over half (65%) of the respondents have been on ART treatment for less than five years. The financial cost, the long distance travelled, and forgetfulness were identified as some of the barriers to ART adherence. Respondents mentioned the provision of health education as one of the strategies that might assist in improving adherence. Conclusion: Non-adherence to ART poses a significant challenge in the study area. The study concluded that lack of knowledge regarding the urgency of follow-up and financial constraints were contributing to ART non-adherence, therefore, HIV education should form part of the curriculum in the basic education syllabus.

show abstract

Long-Acting, Injectable Antiretroviral Therapy for the Management of HIV Infection: An Update on a Potential Game-Changer

Cited by 3 publications

References 46 publications

Willingness to Use Long-acting Injectable Pre-exposure Prophylaxis Among Key Populations at a Large Hiv Prevention Clinic in Kampala, Uganda: a Cross-sectional Study

Willingness to Use Long-acting Injectable Pre-exposure Prophylaxis Among Key Populations at a Large Hiv Prevention Clinic in Kampala, Uganda: a Cross-sectional Study

The LAIs Are Coming! Implementation Science Considerations for Long-Acting Injectable Antiretroviral Therapy in the United States: A Scoping Review

Predictors and Barriers Associated with Non-Adherence to ART by People Living with HIV and AIDS in a Selected Local Municipality of Limpopo Province, South Africa

Contact Info

Product

Resources

About