Long-Acting Phenothiazine Preparations in the Treatment of Schizophrenia

Abstract

CORRESPONDENCE atrophic testes, a normal-sized penis, sparse body hair, XY karyotype, high oestrogen level, and low I 7-KS level; their conclusion is that a primary failure of androgen led to the desire for sex change. They describe a female who stopped menses at 28, developed acne, hirsutism, had a deep voice and an enlarged clitoris; their conclusion is that an elevated androgen level led to the desire for sex change. Unfortunately for the authors' hypothesis, both these clinical pictures are typical of the anatomically normal male and female after a period on oestrogens (for the male) and androgens (for the female)! Had the authors fully read the references they cite, they would had learned that a case to which they refer of a male transsexual with ‘¿ oestrogen-secreting testicular tumour' (Stoller et al., 1960) confessed years later to having secretly taken oestrogens since puberty (Stoller, i988).

Neuroleptische Therapie und Suizid - Literaturübersieht und eigene Resultate

“…1979) -mit extrapyramidalen Störungen, insbesondere Akinesie (van Putten und May 1978) einherging. Kasuistische Mitteilungen berichteten über jeweils kurz nach Fluphenazin-Depotinjektionen auftretende Depressionen, die in 5 Fällen sogar im Suizid gipfelten (de Alarcon und Carney 1969) und darüber, daß sich nach Einstellung auf Depotneuroleptika die Zahl der Suizidversuche bei schizophrenen Patienten verdoppelte (Kernohan 1972). Der Anteil der Depressionen unter den entlassenen, mit Neuroleptika behandelten schizophrenen Patienten ist hoch und wurde kürzlich mit 19-43 % beziffert (Bandelow u. a.…”