The aim of this paper is to analyze the effects of labor market conditions in the origin and the destination on interregional migration in Spain, over the period 1988-2010. A basic theoretical framework is developed and the implications of the model suggest that the effect of labor market conditions on migration can vary, depending on a certain threshold. In a second step, the implications of the model are tested with Spanish data, using a new approach based on the presence of thresholds. We show that interregional migration can be explained by labor market fundamentals if the expected wage gap between the origin and the destination is below an endogenously determinate value.JEL Code: R23, C20, J61