1991
DOI: 10.1016/0955-2863(91)90030-9
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Long-chain fatty acid metabolism in fasting and diabetes: relation between altered desaturase activity and fatty acid composition

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Cited by 64 publications
(38 citation statements)
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“…3). This observation is particularly interesting because ⌬-6 desaturase is often considered the enzyme which catalyzes the rate-limiting step in the synthesis of 20-and 22-carbon polyenoic fatty acids (20,25,27). Regardless of which gene has the higher level of mRNA, the observation that many tissues express detectable levels of both ⌬-5 and ⌬-6 desaturase is consistent with the importance that the desaturase pathway plays in producing 20-and 22-carbon polyenoic fatty acids (e.g.…”
Section: Resultsmentioning
confidence: 99%
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“…3). This observation is particularly interesting because ⌬-6 desaturase is often considered the enzyme which catalyzes the rate-limiting step in the synthesis of 20-and 22-carbon polyenoic fatty acids (20,25,27). Regardless of which gene has the higher level of mRNA, the observation that many tissues express detectable levels of both ⌬-5 and ⌬-6 desaturase is consistent with the importance that the desaturase pathway plays in producing 20-and 22-carbon polyenoic fatty acids (e.g.…”
Section: Resultsmentioning
confidence: 99%
“…For example, the enzymatic activity of both desaturases is reduced by diabetes, and this is associated with a reduced tissue content of 20:4(n-6) (27,29,30). Similarly, the hepatic activity of both desaturases is suppressed by fasting and induced by re-feeding carbohydrate (25,27). However, molecular evidence for these conclusions has been lacking because the mammalian ⌬-6 and ⌬-5 desaturases had neither been cloned nor purified.…”
mentioning
confidence: 97%
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“…Elongation of DGLA was also demonstrated to be insulin dependent (Mimouni etal, 1992). Very recently, Mimouni et al (1994) (Poisson and Cunnane, 1991). ).…”
Section: Dietary Sources Of Essential Fatty Acidsmentioning
confidence: 99%
“…Cette observation n'est pas nécessairement surprenante quand on sait qu'il n'existe pas de relations simples entre modification d'activité désaturante et changement de composition en acides gras. En effet, la composition en acides gras dépend non seulement des étapes de désaturation/élongation mais aussi d'autres aspects du métabolisme lipidique, incluant l'oxydation, la disponibilité en substrat, l'acylation, la synthèse d'éicosanoïdes, ainsi que l'état nutritionnel et hormonal [22]. En revanche, l'activité de delta-6 n-3 désaturation, partiellement inhibée chez le rat SHR [14], est significativement augmentée dans le lot Fructose.…”
Section: Discussionunclassified