Long‐chain fatty acids are bad in <scp>IPF</scp>, or are they?

McManus, Bruce M.; Knight, Darryl A.

doi:10.1111/resp.13981

Cited by 1 publication

(1 citation statement)

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“…The PLIN1 gene encodes perilipin 1, a protein primarily involved in lipid metabolism by regulating lipolysis in adipocytes [26,27]. Lipids have been shown to exacerbate the progression of lung fibrosis [28], and inhibiting lipolysis leads to an increase in dermal ECM deposition [29]. Additionally, studies have reported that PLIN1-knockout mice exhibit sustained inflammation due to increased storage of lipid droplets in adipocytes [30].…”

Section: Discussionmentioning

confidence: 99%

Transcriptional Changes in Radiation-Induced Lung Injury: A Comparative Analysis of Two Radiation Doses for Preclinical Research

Farh,

Kim,

Kim

et al. 2024

IJMS

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In a recent stereotactic body radiation therapy animal model, radiation pneumonitis and radiation pulmonary fibrosis were observed at around 2 and 6 weeks, respectively. However, the molecular signature of this model remains unclear. This study aimed to examine the molecular characteristics at these two stages using RNA-seq analysis. Transcriptomic profiling revealed distinct transcriptional patterns for each stage. Inflammatory response and immune cell activation were involved in both stages. Cell cycle processes and response to type II interferons were observed during the inflammation stage. Extracellular matrix organization and immunoglobulin production were noted during the fibrosis stage. To investigate the impact of a 10 Gy difference on fibrosis progression, doses of 45, 55, and 65 Gy were tested. A dose of 65 Gy was selected and compared with 75 Gy. The 65 Gy dose induced inflammation and fibrosis as well as the 75 Gy dose, but with reduced lung damage, fewer inflammatory cells, and decreased collagen deposition, particularly during the inflammation stage. Transcriptomic analysis revealed significant overlap, but differences were observed and clarified in Gene Ontology and KEGG pathway analysis, potentially influenced by changes in interferon-gamma-mediated lipid metabolism. This suggests the suitability of 65 Gy for future preclinical basic and pharmaceutical research connected with radiation-induced lung injury.

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