Long Chain PUFA Transport in Human Term Placenta

Regulation of fatty acid binding proteins by hypoxia inducible factors 1α and 2α in the placenta: Relevance to pre-eclampsia

“…These include three intracellular liver, heart and adipocyte fatty acid binding proteins (FABP1, FABP3, and FABP4 respectively) and membrane associated fatty acid transport protein 2/very long chain acyl CoA synthetase 1 (FATP2) [6]. The protein levels of FABP1, FABP3 and FABP4 increase in hypoxic human trophoblasts [7].…”

Interrelation of Changes in Concentration of Leptin and Ω-3 Family Acids in the Placenta at the Reactivation of Cytomegalovirus Infection in the Iii Trimester of Human Pregnancy

“…Транспорт ЖК через плацентарный барьер осу-ществляется простой диффузией [13] и с помощью специальных липид-переносящих белков [8,14]. Также плацента может регулировать свою собствен-ную поставку субстрата ЖК посредством действия плацентарного лептина на жировую ткань матери [10].…”

Acute fatty liver of pregnancy: an update on mechanisms

“…In addition, placental macrophages (Hofbauer cells) represent 40% of the placental cell population, and are located close to trophoblasts and fetal capillaries where they can also contribute to free radical generation. 16 However, until now, no study has addressed the significance of these cells in AFLP.…”

“…Placental plasma membrane FA -binding protein and FATP 4 are mainly involved in the uptake of long chain FA such as docosahexanoic acid and other FA binding proteins like FABP 1, 3, 4, 5 and 7 have also been detected in the placental syncytiotrophoblast. 16 Two of the most important long chain polyunsaturated FAs such as arachidonic acid (AA) and docosahexanoic acid are markedly increased in the fetal circulation as well as fetal tissues such as brain due to their need for its development. 5 Activation and acylation of FAs for b-oxidation occurs in the outer mitochondrial membrane by acyl CoA synthase and carnitine acyl transferase I to form acyl-carnitines.…”