Long-circulating self-assembled cholesteryl albumin nanoparticles enhance tumor accumulation of hydrophobic anticancer drug

Battogtokh, Gantumur; Kang, Ji Hee; Ko, Young Tag

doi:10.1016/j.ejpb.2015.07.013

Cited by 40 publications

(23 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The paclitaxel–Chol–BSA structure was prepared via self-assembly with high colloidal stability in comparison to structures without Chol. The NPs had a 147.6 ± 1.6-nm hydrodynamic diameter and a high drug-loading capacity [62]. Paclitaxel–Chol–BSA NPs acted as an efficient agent showing sustained drug release (Figure 4(b)).…”

Section: Albumin Nanostructuresmentioning

confidence: 99%

See 1 more Smart Citation

Albumin nanostructures as advanced drug delivery systems

Karimi

Bahrami

Ravari

et al. 2016

Expert Opinion on Drug Delivery

331

190

View full text Add to dashboard Cite

Introduction One of the biggest impacts that the nanotechnology has made on medicine and biology, has been in the area of drug delivery systems (DDSs). Many drugs suffer from serious problems concerning insolubility, instability in biological environments, poor uptake into cells and tissues, suboptimal selectivity for targets and unwanted side effects. Nanocarriers can be designed as DDSs to overcome many of these drawbacks. One of the most versatile building blocks to prepare these nanocarriers is the ubiquitous, readily available and inexpensive protein, serum albumin. Areas covered This review covers the use of different types of albumin (human, bovine, rat, and chicken egg) to prepare nanoparticle and microparticle-based structures to bind drugs. Various methods have been used to modify the albumin structure. A range of targeting ligands can be attached to the albumin that can be recognized by specific cell receptors that are expressed on target cells or tissues. Expert opinion The particular advantages of albumin used in DDSs include ready availability, ease of chemical modification, good biocompatibility, and low immunogenicity. The regulatory approvals that have been received for several albumin-based therapeutic agents suggest that this approach will continue to be successfully explored.

show abstract

Section: Albumin Nanostructuresmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Albumin nanostructures as advanced drug delivery systems

Karimi

Bahrami

Ravari

et al. 2016

Expert Opinion on Drug Delivery

331

190

View full text Add to dashboard Cite

show abstract

“…To circumvent the aforementioned problem, Battogtokh et al synthesized cholesteryl bovine serum albumin (Chol-BSA) ( Scheme 3 ) nanoparticles ( 6 ) as PTX carriers. When loaded with PTX, nanoparticles 6 showed a 94.8% drug loading efficiency and 37.9% drug loading capacity making the formulation a potential drug carrier than its closest competitors [ 50 ]. The nanoparticles had an optimum size of 150 nm and a negative charge surface making them stable in aqueous medium [ 51 ].…”

Section: Application Of Cholesterol-based Carriers In Anticancer Dmentioning

confidence: 99%

“…After incubating PTX-loaded nanoparticles 6 with MCF-7 cells for 1 h, the uptake of the nanoparticles was reported to be 3.5- and 1.4-fold higher when compared to PTX-Cre/EtOH and PTX–BSA, respectively. These findings revealed the capability of the PTX-loaded nanoparticles 6 in delivering more drugs to the cells [ 50 ].…”

Section: Application Of Cholesterol-based Carriers In Anticancer Dmentioning

confidence: 99%

The Efficacy of Cholesterol-Based Carriers in Drug Delivery

Ruwizhi

Aderibigbe

2020

Molecules

View full text Add to dashboard Cite

Several researchers have reported the use of cholesterol-based carriers in drug delivery. The presence of cholesterol in cell membranes and its wide distribution in the body has led to it being used in preparing carriers for the delivery of a variety of therapeutic agents such as anticancer, antimalarials and antivirals. These cholesterol-based carriers were designed as micelles, nanoparticles, copolymers, liposomes, etc. and their routes of administration include oral, intravenous and transdermal. The biocompatibility, good bioavailability and biological activity of cholesterol-based carriers make them potent prodrugs. Several in vitro and in vivo studies revealed cholesterol-based carriers potentials in delivering bioactive agents. In this manuscript, a critical review of the efficacy of cholesterol-based carriers is reported.

show abstract

“…16 In addition, tumors tend to trap plasma proteins and utilize their degradation products for proliferation, which means that the albumin-based NPs are easily trapped by cancer cells by the 60 kDa glycoprotein receptor binding. 17,18 Recently, NP-based contrast agents have attracted extraordinary attention for functional and molecular imaging investigations. 19,20 It has been reported that multimolecular imaging modalities provide complementary information for concurrent imaging applications and hence have become an attractive area of investigation (ie, magnetic resonance [MR]/fluorescence imaging, photoinduced electron transfer/fluorescence, MR/ultrasound imaging, and photoinduced electron transfer/CT).…”

Section: Introductionmentioning

confidence: 99%

1,3-Bis(2-chloroethyl)-1-nitrosourea-loaded bovine serum albumin nanoparticles with dual magnetic resonance–fluorescence imaging for tracking of chemotherapeutic agents

Wei

Lin

Huang

et al. 2016

IJN

View full text Add to dashboard Cite

To date, knowing how to identify the location of chemotherapeutic agents in the human body after injection is still a challenge. Therefore, it is urgent to develop a drug delivery system with molecular imaging tracking ability to accurately understand the distribution, location, and concentration of a drug in living organisms. In this study, we developed bovine serum albumin (BSA)-based nanoparticles (NPs) with dual magnetic resonance (MR) and fluorescence imaging modalities (fluorescein isothiocyanate [FITC]-BSA-Gd/1,3-bis(2-chloroethyl)-1-nitrosourea [BCNU] NPs) to deliver BCNU for inhibition of brain tumor cells (MBR 261-2). These BSA-based NPs are water dispersible, stable, and biocompatible as confirmed by XTT cell viability assay. In vitro phantoms and in vivo MR and fluorescence imaging experiments show that the developed FITC-BSA-Gd/BCNU NPs enable dual MR and fluorescence imaging for monitoring cellular uptake and distribution in tumors. The T1 relaxivity (R1) of FITC-BSA-Gd/BCNU NPs was 3.25 mM −1 s −1 , which was similar to that of the commercial T1 contrast agent (R1 =3.36 mM −1 s −1 ). The results indicate that this multifunctional drug delivery system has potential bioimaging tracking of chemotherapeutic agents ability in vitro and in vivo for cancer therapy.

show abstract

Long-circulating self-assembled cholesteryl albumin nanoparticles enhance tumor accumulation of hydrophobic anticancer drug

Cited by 40 publications

References 32 publications

Albumin nanostructures as advanced drug delivery systems

Albumin nanostructures as advanced drug delivery systems

The Efficacy of Cholesterol-Based Carriers in Drug Delivery

1,3-Bis(2-chloroethyl)-1-nitrosourea-loaded bovine serum albumin nanoparticles with dual magnetic resonance–fluorescence imaging for tracking of chemotherapeutic agents

Contact Info

Product

Resources

About

Long-circulating self-assembled cholesteryl albumin nanoparticles enhance tumor accumulation of hydrophobic anticancer drug

Cited by 40 publications

References 32 publications

Albumin nanostructures as advanced drug delivery systems

Albumin nanostructures as advanced drug delivery systems

The Efficacy of Cholesterol-Based Carriers in Drug Delivery

1,3-Bis(2-chloroethyl)-1-nitrosourea-loaded bovine serum albumin nanoparticles with dual magnetic resonance&ndash;fluorescence imaging for tracking of chemotherapeutic agents

Contact Info

Product

Resources

About

1,3-Bis(2-chloroethyl)-1-nitrosourea-loaded bovine serum albumin nanoparticles with dual magnetic resonance–fluorescence imaging for tracking of chemotherapeutic agents