Long COVID-associated symptoms prevalent in both SARS-CoV-2 positive and negative individuals: A prospective follow-up study

Kantele, Anu; Paajanen, Juuso; Pietilä, Jukka-Pekka; Vapalahti, Olli; Pakkanen, Sari H.; Lääveri, Tinja

doi:10.1016/j.nmni.2023.101209

Cited by 3 publications

(3 citation statements)

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“…We selected impaired olfaction as a representative of PASC symptoms because, together with impaired sense of taste, it was the only symptom that was more common among the SARS-CoV-2-positive than -negative individuals in our master study [ 16 ]. Moreover, unlike more generic symptoms, such as fatigue, it is uncommon among SARS-CoV-2-negative individuals [ 17 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…We chose to use impaired olfaction as a proxy of persisting symptoms after acute COVID-19, as it has been most commonly associated with PASC. Moreover, unlike many other symptoms, such as fatigue, it is uncommon among SARS-CoV-2-negative individuals [16][17][18]. The data on persisting symptoms used here were obtained from the Long Covid Master study [16] with 1326 participants whose symptoms were evaluated with an online questionnaire.…”

Section: Persisting Symptomsmentioning

confidence: 99%

“…Moreover, unlike many other symptoms, such as fatigue, it is uncommon among SARS-CoV-2-negative individuals [16][17][18]. The data on persisting symptoms used here were obtained from the Long Covid Master study [16] with 1326 participants whose symptoms were evaluated with an online questionnaire.…”

Section: Persisting Symptomsmentioning

confidence: 99%

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Stable Levels of Antibodies Against Unrelated Toxoid Vaccines After COVID-19: COVID-19 Infection Does Not Affect Toxoid Vaccine Antibody Levels

Jokiranta,

Miettinen,

Salonen

et al. 2024

PAI

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Background: Lymphopenia is common in COVID-19. This has raised concerns that COVID-19 could affect the immune system akin to measles infection, which causes immune amnesia and a reduction in protective antibodies. Methods: We recruited COVID-19 patients (n = 59) in Helsinki, Finland, and collected plasma samples on 2 to 3 occasions during and after infection. We measured IgG antibodies to diphtheria toxin, tetanus toxoid, and pertussis toxin, along with total IgG, SARS-CoV-2 spike protein IgG, and neutralizing antibodies. We also surveyed the participants for up to 17 months for long-term impaired olfaction as a proxy for prolonged post-acute COVID-19 symptoms. Results: No significant differences were found in the unrelated vaccine responses while the serological response against COVID-19 was appropriate. During the acute phase of the disease, the SARS-CoV-2 IgG levels were lower in outpatients when compared to inpatients. SARS-CoV-2 serology kinetics matched expectations. In the acute phase, anti-tetanus and anti-diphtheria IgG levels were lower in patients with prolonged impaired olfaction during follow up than in those without. Conclusions: We could not detect significant decline in overall humoral immunity during or after COVID-19 infection. In severe COVID-19, there appears to be a temporary decline in total IgG levels.

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Section: Discussionmentioning

confidence: 99%