Long COVID: Long-Term Impact of SARS-CoV2

Makhluf, Huda; Madany, Henry; Kim, Kenneth

doi:10.3390/diagnostics14070711

Cited by 6 publications

(1 citation statement)

References 79 publications

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“…Anyone can get sick with COVID-19 and become seriously ill and die at any age [2]. Among many lifestyle changes the pandemic brought, like sleep, work, and shopping changes, were social distancing and masking [3][4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Important Repercussions of the COVID-19 Pandemic Lifestyle Avoided by Researchers? Face Masks and Temporomandibular Disorders: A Systematic Search and Review

Pietrzyk,

Kielczynska,

Kowalczyk

et al. 2024

Preprint

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Since December 2019, the COVID-19 virus has rapidly spread worldwide, prompting the World Health Organization (WHO) to declare it a pandemic and advocate for the widespread use of face masks to mitigate transmission. In this review, we delve into the potential impact of prolonged face mask use on temporomandibular joint (TMJ) health, an area that has garnered limited attention amidst COVID-19 research. Research has revealed that improper mask fit, and constant readjustment can lead to TMJ abnormalities. Similarly, there is a demonstrated correlation between continuous mask usage and increased incidence of headaches, temporomandibular pain, and diminished quality of life. Many studies have highlighted discomfort in the preauricular area, headaches, TMJ noises, headache, jaw pain, and muscle fatigue, as well as dermatological disorders that have been attributed to prolonged mask wear and its impact on TMJ. Our study catalyzes future research endeavors, urging a deeper exploration of the implications of long-term mask wear, not only in the context of the COVID-19 pandemic but also among occupational groups regularly exposed to extended mask use. By unraveling the complexities of TMJ health in the face of evolving preventive measures, we aim to enhance our understanding and safeguard the well-being of mask-wearers worldwide.

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Section: Introductionmentioning

confidence: 99%

Important Repercussions of the COVID-19 Pandemic Lifestyle Avoided by Researchers? Face Masks and Temporomandibular Disorders: A Systematic Search and Review

Pietrzyk,

Kielczynska,

Kowalczyk

et al. 2024

Preprint

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Is there a rationale for hyperbaric oxygen therapy in the patients with Post COVID syndrome?

Pawlik,

Rinneberg,

Koch

et al. 2024

Eur Arch Psychiatry Clin Neurosci

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The SARS-CoV-2 pandemic has resulted in 762 million infections worldwide from 2020 to date, of which approximately ten percent are suffering from the effects after infection in 2019 (COVID-19) [1, 40]. In Germany, it is now assumed that at least one million people suffer from post-COVID condition with long-term consequences. These have been previously reported in diseases like Myalgic Encephalomyelitis (ME) and Chronic Fatigue Syndrome (CFS). Symptoms show a changing variability and recent surveys in the COVID context indicate that 10–30 % of outpatients, 50 to 70% of hospitalised patients suffer from sequelae. Recent data suggest that only 13% of all ill people were completely free of symptoms after recovery [3, 9]. Current hypotheses consider chronic inflammation, mitochondrial dysfunction, latent viral persistence, autoimmunity, changes of the human microbiome or multilocular sequelae in various organ system after infection. Hyperbaric oxygen therapy (HBOT) is applied since 1957 for heart surgery, scuba dive accidents, CO intoxication, air embolisms and infections with anaerobic pathogens. Under hyperbaric pressure, oxygen is physically dissolved in the blood in higher concentrations and reaches levels four times higher than under normobaric oxygen application. Moreover, the alternation of hyperoxia and normoxia induces a variety of processes at the cellular level, which improves oxygen supply in areas of locoregional hypoxia. Numerous target gene effects on new vessel formation, anti-inflammatory and anti-oedematous effects have been demonstrated [74]. The provision of intermittently high, local oxygen concentrations increases repair and regeneration processes and normalises the predominance of hyperinflammation. At present time only one prospective, randomized and placebo-controlled study exists with positive effects on global cognitive function, attention and executive function, psychiatric symptoms and pain interference. In conclusion, up to this date HBO is the only scientifically proven treatment in a prospective randomized controlled trial to be effective for cognitive improvement, regeneration of brain network and improvement of cardiac function. HBOT may have not only theoretical but also potential impact on targets of current pathophysiology of Post COVID condition, which warrants further scientific studies in patients.

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Neutralizing antibody titers predict protection from virus transmission in a cohort of household members with documented exposure to SARS-CoV-2

Maaß,

Hinrichs,

Pavletic

et al. 2024

Preprint

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Background While correlates of protection against symptomatic and severe breakthrough SARS-CoV-2 infections are well characterized, correlates of protection against virus transmission are incompletely understood. Methods We studied a Croatian cohort of individuals with documented household exposure to SARS-CoV-2 in December 2022. Sera were acquired prior to symptom onset, at the time of the COVID-19 diagnosis of the index cases, and comprehensively analyzed for correlates of protection against virus transmission. We monitored participants for 14 days and tested them with PCR at the end of the observation period to identify any virus transmission, including asymptomatic ones. Interpretation Out of nearly 200 tested serological parameters, 22 features were significantly different between the infected and the uninfected participants. Titers of variant-specific neutralizing antibody showed the biggest difference and were significantly higher in the uninfected subgroup. Some infected individuals with strong IgM responses to the spike antigen showed robust neutralization titers as well. Since IgM is likely an indication of recent antigenic exposure, data were reanalyzed by excluding such values. This refined analysis showed a complete segregation of infected and uninfected individuals into groups with low and high variant-specific neutralization titers. Therefore, our data indicate that high neutralizing titers are correlates of protection against SARS-CoV-2 transmission in intense contacts among household members.

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Long COVID: Long-Term Impact of SARS-CoV2

Cited by 6 publications

References 79 publications

Important Repercussions of the COVID-19 Pandemic Lifestyle Avoided by Researchers? Face Masks and Temporomandibular Disorders: A Systematic Search and Review

Important Repercussions of the COVID-19 Pandemic Lifestyle Avoided by Researchers? Face Masks and Temporomandibular Disorders: A Systematic Search and Review

Is there a rationale for hyperbaric oxygen therapy in the patients with Post COVID syndrome?

Neutralizing antibody titers predict protection from virus transmission in a cohort of household members with documented exposure to SARS-CoV-2

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