“Long COVID” results after hospitalization for SARS-CoV-2 infection

Abstract

Long-term sequelae of symptomatic infection caused by SARS-CoV-2 are largely undiscovered. We performed a prospective cohort study on consecutively hospitalized Sars-CoV-2 patients (March–May 2020) for evaluating COVID-19 outcomes at 6 and 12 months. After hospital discharge, patients were addressed to two follow-up pathways based on respiratory support needed during hospitalization. Outcomes were assessed by telephone consultation or ambulatory visit. Among 471 patients, 80.9% received no respiratory support during hospitalization; 19.1% received non-invasive ventilation (NIV) or invasive mechanical ventilation (IMV). 58 patients died during hospitalization, therefore 413 were enrolled for follow-up. At 6 months, among 355 patients, the 30.3% had any symptoms, 18.0% dyspnea, 6.2% neurological symptoms. Fifty-two out of 105 had major damages in interstitial computed tomography images. NIV/IMV patients had higher probability to suffer of symptoms (aOR = 4.00, 95%CI:1.99–8.05), dyspnea (aOR = 2.80, 95%CI:1.28–6.16), neurological symptoms (aOR = 9.72, 95%CI:2.78–34.00). At 12 months, among 344, the 25.3% suffered on any symptoms, 12.2% dyspnea, 10.1% neurological symptoms. Severe interstitial lesions were present in 37 out of 47 investigated patients. NIV/IMV patients in respect to no respiratory support, had higher probability of experiencing symptoms (aOR = 3.66, 95%CI:1.73–7.74), neurological symptoms (aOR = 8.96, 95%CI:3.22–24.90). COVID-19 patients showed prolonged sequelae up to 12 months, highlighting the need of follow-up pathways for post-COVID-19 syndrome.

Undiagnosed Long COVID-19 in China Among Non-vaccinated Individuals: Identifying Persistent Symptoms and Impacts on Patients' Health-Related Quality of Life

“…Other symptoms reported in other studies, including sleep disorders [ 4 , 6 , 7 ] and memory problems [ 4 , 5 , 7 ] were also complains identified in our study. In this regard, we can argue that emotional disorders and cognitive impairment might be caused by persistent inflammation.…”

“…Other available studies focused on the patients' mental/psychological sequelae, of which cognitive impairment was the most common problem [ 2 , 5 – 7 , 9 ]. Emotional disorders, such as anxiety/depression, plagued the patients' daily life [ 2 , 4 , 5 , 7 , 22 , 27 ], which is also a set of persistent symptoms with high recurrence [ 44 ]. Our data for China are in agreement with these studies.…”

“…For this study, the considered definitions of Long COVID-19 include that of a condition where individuals have any symptoms persisting for at least 1 year or persisting symptom during the follow-up time [ 4 ]. This observation is accepted as post-COVID-19 syndrome and referred to the related symptoms and sequelae due to long-term impact of COVID-19 [ 5 ].…”

The Use of Palmitoylethanolamide in the Treatment of Long COVID: A Real-Life Retrospective Cohort Study

“…The main symptoms include extreme tiredness, shortness of breath, chest pain or tightness and “brain fog” (that is problems with memory and concentration), as well as difficulty sleeping, heart palpitations, dizziness and joint pain. Persistence of anosmia and dysgeusia [ 9 ] or neuropsychiatric complications are also possible [ 10 , 11 , 12 , 13 ]. Therefore, the increasing importance of long COVID symptoms and burden, led the WHO organization to plan several international meetings with experts reaching a consensus on a definition and reporting details and the subtypes and case definitions of this condition [ 13 ].…”

Оценка Эффективности И Безопасности Применения Доксофиллина При Постковидном Респираторном Синдроме У Пациентов С Продолжающимся И Долгим Ковидом

“…52 из 105 больных имели картину существенных интерстициальных изменений на изображениях компьютерной томографии. На протяжении 12 месяцев наблюдения из 344 больных у 25,3% имелись те или иные симптомы, у 12,2% отмечалась одышка и у 10,1% -неврологические симптомы [3].…”