Long COVID risk - a signal to address sex hormones and women's health

Stewart, Stuart; Newson, Louise; Briggs, Tracy A; Grammatopoulos, Dimitris K.; Young, Lawrence S.; Gill, Paramjit

doi:10.1016/j.lanepe.2021.100242

Cited by 66 publications

(71 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The present study also recognizes female sex as a risk factor associated with post-COVID syndrome. 6,7 As shown in the Supplementary Materials (Table 1), careful comparison of the RHR and NOI parameters collected for females and males seems to corroborate a difference in risk based on sex. For example, the RHR parameter is higher for females than males in the control group, but there is no such difference in the post-COVID group.…”

Section: Resultsmentioning

confidence: 66%

“…The apparent higher risk of females to post-COVID syndrome may indicate viral-induced sex hormone dysfunction, which can result in early menopause, as observed for other viral diseases. 6…”

Section: Resultsmentioning

confidence: 99%

“…The apparent higher risk of females to post-COVID syndrome may indicate viral-induced sex hormone dysfunction, which can result in early menopause, as observed for other viral diseases. 6 In previous communications, we have suggested that the Hypoxia Sensitivity (HS) parameter can be used to predict severity of the acute phase of COVID-19 infection.…”

Section: Resultsmentioning

confidence: 99%

“…4,5 Female sex is a risk factor associated with post-COVID syndrome, with sex hormones possibly playing an important role in that risk. 6,7…”

Section: Introductionmentioning

confidence: 99%

“…4,5 Female sex is a risk factor associated with post-COVID syndrome, with sex hormones possibly playing an important role in that risk. 6,7 The list of post-COVID symptoms is long, but fatigue is the most common, occurring in more than 70% of post-COVID patients. There is limited mechanistic knowledge explaining the pathophysiology of chronic fatigue associated with post-COVID.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Chronic fatigue associated with post-COVID syndrome versus transient fatigue caused by high intensity exercise: are they comparable in terms of vascular effects?

Chudzik

Cender²,

Mordaka³

et al. 2022

Preprint

View full text Add to dashboard Cite

Purpose: The pathophysiology of chronic fatigue associated with post-COVID syndrome is not well recognized. It is assumed that this condition is partly due to vascular dysfunction developed during an acute phase of infection. There is great demand for a diagnostic tool that is able to clinically assess post-COVID syndrome and monitor the rehabilitation process. Patients and Methods: The Flow Mediated Skin Fluorescence (FMSF) technique appears uniquely suitable for the analysis of basal microcirculatory oscillations and reactive hyperemia induced by transient ischemia. The FMSF was used to measure vascular circulation in 45 patients with post-COVID syndrome. The results were compared with those for a group of 26 amateur runners before and after high intensity exercise, as well as for a control group of 32 healthy age-matched individuals. Results: Based on the NOI and RHR parameters measured with the FMSF technique, it was found that chronic fatigue associated with post-COVID syndrome is comparable with transient fatigue caused by high-intensity exercise in terms of vascular effects. Both chronic fatigue associated with post-COVID syndrome and transient fatigue caused by high-intensity exercise are associated with vascular stress in the macrocirculation and microcirculation. Conclusion: The NOI and RHR parameters measured with the FMSF technique can be used for non-invasive clinical assessment of post-COVID syndrome, as well as for monitoring the rehabilitation process.

show abstract

Section: Resultsmentioning

confidence: 66%

“…The apparent higher risk of females to post-COVID syndrome may indicate viral-induced sex hormone dysfunction, which can result in early menopause, as observed for other viral diseases. 6…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…4,5 Female sex is a risk factor associated with post-COVID syndrome, with sex hormones possibly playing an important role in that risk. 6,7…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Chronic fatigue associated with post-COVID syndrome versus transient fatigue caused by high intensity exercise: are they comparable in terms of vascular effects?

Chudzik

Cender²,

Mordaka³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

Incidence of long COVID-19 in people with previous SARS-Cov2 infection: a systematic review and meta-analysis of 120,970 patients

et al. 2022

View full text Add to dashboard Cite

The long-term consequences of the coronavirus disease 19 (COVID-19) are likely to be frequent but results hitherto are inconclusive. Therefore, we aimed to define the incidence of long-term COVID signs and symptoms as defined by the World Health Organization, using a systematic review and meta-analysis of observational studies. A systematic search in several databases was carried out up to 12 January 2022 for observational studies reporting the cumulative incidence of long COVID signs and symptoms divided according to body systems affected. Data are reported as incidence and 95% confidence intervals (CIs). Several sensitivity and meta-regression analyses were performed. Among 11,162 papers initially screened, 196 were included, consisting of 120,970 participants (mean age: 52.3 years; 48.8% females) who were followed-up for a median of six months. The incidence of any long COVID symptomatology was 56.9% (95% CI 52.2–61.6). General long COVID signs and symptoms were the most frequent (incidence of 31%) and digestive issues the least frequent (7.7%). The presence of any neurological, general and cardiovascular long COVID symptomatology was most frequent in females. Higher mean age was associated with higher incidence of psychiatric, respiratory, general, digestive and skin conditions. The incidence of long COVID symptomatology was different according to continent and follow-up length. Long COVID is a common condition in patients who have been infected with SARS-CoV-2, regardless of the severity of the acute illness, indicating the need for more cohort studies on this topic.

show abstract