Long cruising aptamer-albumin nanobots intelligently capture and restrain circulating tumor cells

Wang, Jie; Xu, Huo; Li, Shuhui; Lin, Min; Lu, Yusheng; Liu, Kuancan; Katanaev, Vladimir; Denisov, Evgeny V.; Jia, Lee

doi:10.1016/j.nantod.2023.102002

Cited by 1 publication

(5 citation statements)

References 32 publications

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“…designed to counteract the main neoplastic hallmark features of BC by sustaining proliferative pathways [31,32], evading growth suppressors/evasion of anti-growth signaling [12], resisting programmed cell death [33][34][35][36][37][38][39][40][41][42], inducing angiogenesis (neovascularization) [43][44][45][46], activating invasion and metastasis [47][48][49], preventing genomic instability, mutation, mitosis/cell cycle deregulation [50], evading/avoiding immune destruction [51] and deregulating autophagy [52,53].…”

Section: Nano-"magic Bullets" In Bc Theranosticsmentioning

confidence: 99%

“…Nanotechnologies have been widely applied in oncological research through multiple strategies to target and alleviate these hallmarks, from automatic nanorobots that induce mitochondria-mediated apoptosis and mitochondrial deregulation to improve the anticancer effects and suppression of cancer metastasis [89] to nanotechnology-based metabolic reprogramming strategies for enhanced tumor immunotherapies [114], or to self-propelling nanosized robots in blood, for CTCs capture [48]. The multiple roles of several types of nanorobots, among other nanomaterials, in BC therapy and diagnosis are summarized in Figure 2.…”

Section: Breast Cancer Hallmark Featuresmentioning

confidence: 99%

“…This Mg-Fe 3 O 4 -GSH-G4-Cy5-Ab/Tf (called Janus MFN) nanobot was prepared by fabricating a hemispherical shell of Fe 3 O 4 on Mg NPs selectively loaded with an anti-epithelial cell adhesion molecule (EpCAM) monoclonal antibody (Ab)/transferrin (Tf) for targeting MCF7 BC cells, a dye, cyanine 5 NHS (Cy5) for particle fluorescent labelling, a fourth generation (G4) dendrimer for multiple conjugation and a glutathione (GSH) linker. For a similar purpose, Wang et al ( 2023) developed a long cruising and intelligent aptamer (AP)-albumin nanorobot able to capture and restrain CTCs by conjugation of CTC-targeting circulating trivalent aptamers (CTA) with human serum albumin (HSA), resulting in CTA-HSA nanorobots that are able to circulate for longer in the blood, with an increased probability of collision and the ability to capture more CTCs [48]. Anti-metastatic functions of nanorobots are illustrated in Figure 4.…”

Section: Anti-invasion and Anti-metastatic Nanomaterialsmentioning

confidence: 99%

“…Cruise in blood longer, capture more CTCs, escape the immune clearance, inhibit invasion/adhesion and cell cycle of CTCs, induce CTCs apoptosis and prevent CTCinduced metastasis [48] CTL-inspired nanovesicles (MPV) with a cell membrane-derived shell and MB and Pt loaded gelatin nanogel core.…”

Section: Activating Invasion and Metastasismentioning

confidence: 99%

“…In this review, readers will be able to deepen their knowledge of the structure, behavior and role of nanorobots, among other nanomaterials, in BC theranostic. We have summarized here the characteristics of several functionalized nanodevices that have been designed to counteract the main neoplastic hallmark features of BC by sustaining proliferative path-ways [31,32], evading growth suppressors/evasion of anti-growth signaling [12], resisting programmed cell death [33][34][35][36][37][38][39][40][41][42], inducing angiogenesis (neovascularization) [43][44][45][46], activating invasion and metastasis [47][48][49], preventing genomic instability, mutation, mitosis/cell cycle deregulation [50], evading/avoiding immune destruction [51] and deregulating autophagy [52,53].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

A Nanorobotics-Based Approach of Breast Cancer in the Nanotechnology Era

Neagu,

Jayaweera,

Weraduwage

et al. 2024

IJMS

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We are living in an era of advanced nanoscience and nanotechnology. Numerous nanomaterials, culminating in nanorobots, have demonstrated ingenious applications in biomedicine, including breast cancer (BC) nano-theranostics. To solve the complicated problem of BC heterogeneity, non-targeted drug distribution, invasive diagnostics or surgery, resistance to classic onco-therapies and real-time monitoring of tumors, nanorobots are designed to perform multiple tasks at a small scale, even at the organelles or molecular level. Over the last few years, most nanorobots have been bioengineered as biomimetic and biocompatible nano(bio)structures, resembling different organisms and cells, such as urchin, spider, octopus, fish, spermatozoon, flagellar bacterium or helicoidal cyanobacterium. In this review, readers will be able to deepen their knowledge of the structure, behavior and role of several types of nanorobots, among other nanomaterials, in BC theranostics. We summarized here the characteristics of many functionalized nanodevices designed to counteract the main neoplastic hallmark features of BC, from sustaining proliferation and evading anti-growth signaling and resisting programmed cell death to inducing angiogenesis, activating invasion and metastasis, preventing genomic instability, avoiding immune destruction and deregulating autophagy. Most of these nanorobots function as targeted and self-propelled smart nano-carriers or nano-drug delivery systems (nano-DDSs), enhancing the efficiency and safety of chemo-, radio- or photodynamic therapy, or the current imagistic techniques used in BC diagnosis. Most of these nanorobots have been tested in vitro, using various BC cell lines, as well as in vivo, mainly based on mice models. We are still waiting for nanorobots that are low-cost, as well as for a wider transition of these favorable effects from laboratory to clinical practice.

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