The complex red-bed geology is primarily composed of iron-rich sedimentary rock layers with clay minerals as a major component. The soil water content exceeds 30%, and its high viscosity and water content lead to the easy formation of mud cake on the cutterhead, endangering the safety and progress of construction, which poses a significant challenge for tunnel boring machines (TBMs). The use of dispersants to eliminate mud cake is a common method in engineering projects. This paper presents an improved disintegration experiment instrument to study the disintegration characteristics of mud cake from the red-bed geology under different dispersant solutions, proposing a dispersant formulation suitable for the red-bed geology of the Haizhu Bay Tunnel project. The results indicate that mud cake samples exhibit a moderate disintegration effect in pure water. Furthermore, it has been observed that the disintegration effect decreases as the thickness of mud cake increases. Sodium silicate solution was not suitable for treating the red-bed geological mud cake, while sodium hexametaphosphate and oxalic acid solutions had a good promoting effect on the disintegration of red-bed geological mud cake. However, there was a threshold for the dispersant concentration; exceeding this threshold actually worsened the disintegration effect. Ultimately, the engineering application of a 10% oxalic acid solution, which proved effective in disintegrating the mud cake, significantly enhanced the excavation efficiency in the Haizhu Bay Tunnel project.