Long-Distance Lipid Signaling and its Role in Plant Development and Stress Response

Barbaglia, Allison M.; Hoffmann-Benning, Susanne

doi:10.1007/978-3-319-25979-6_14

Cited by 18 publications

(15 citation statements)

References 135 publications

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“…However, since most of the mRNAs are expressed in mesophyll cells, it is unclear how they could enter the phloem stream in the apoplasmic loader A. thaliana . In addition to those many phloem-mobile proteins and mRNAs, the role of microRNAs 87 and lipids 88 as systemic signals needs to be further explored.…”

Section: Phloem Transportmentioning

confidence: 99%

An update on phloem transport: a simple bulk flow under complex regulation

Liesche

Patrick

2017

F1000Res

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The phloem plays a central role in transporting resources and signalling molecules from fully expanded leaves to provide precursors for, and to direct development of, heterotrophic organs located throughout the plant body. We review recent advances in understanding mechanisms regulating loading and unloading of resources into, and from, the phloem network; highlight unresolved questions regarding the physiological significance of the vast array of proteins and RNAs found in phloem saps; and evaluate proposed structure/function relationships considered to account for bulk flow of sap, sustained at high rates and over long distances, through the transport phloem.

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Section: Phloem Transportmentioning

confidence: 99%

An update on phloem transport: a simple bulk flow under complex regulation

Liesche

Patrick

2017

F1000Res

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“…The fast induction of the signalling molecules observed suggests a probable post-translational regulation of the enzymes involved in the process [67] . Although mainly thought to act as a signalling molecule recent discoveries have identified a functional role for PA as a second messenger molecule, PA has been shown to recruit target proteins with varied stress functions such as TFs, protein and lipid kinases, phosphatases and also cytoskeletal rearrangements [87] , [88] . Furthermore, PA would also participate in the ABA cold response, through interaction with sphingosine kinases [89] , that regulate the production of LCB-1-phosphates (LCBPs), including phyto-S1P, although the regulation mediated by this hormone is not fully understood.…”

Section: Introductionmentioning

confidence: 99%

Lipid remodelling: Unravelling the response to cold stress in Arabidopsis and its extremophile relative Eutrema salsugineum

et al. 2017

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HighlightsHigher plants rapidly remodel cellular lipids in response to environmental perturbation and abiotic stress.Lipids in plants perform many important functions including information exchange, protection, energy storage, signalling and light capture.Increases in unsaturation are a common response to cold stress, but not the only mechanism of adaptation.An increased understanding of lipid turnover is essential to establish the contribution made by the lipidome to plant stress resilience.Opportunities exist to improve the resilience of crops by manipulating the lipidome.

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“…Alternatively, they could be (part of) a signal themselves. As such they are released, sensed, and moved by phloem lipid-binding proteins (Benning et al, 2012 ; Hoffmann-Benning, 2015 ; Barbaglia and Hoffmann-Benning, 2016 ). Indeed, the proteins we identified include lipases, that could release the signaling lipid into the phloem, putative receptor components, and proteins that could mediate lipid-movement.…”

Section: Introductionmentioning

confidence: 99%

Phloem Proteomics Reveals New Lipid-Binding Proteins with a Putative Role in Lipid-Mediated Signaling

et al. 2016

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Global climate changes inversely affect our ability to grow the food required for an increasing world population. To combat future crop loss due to abiotic stress, we need to understand the signals responsible for changes in plant development and the resulting adaptations, especially the signaling molecules traveling long-distance through the plant phloem. Using a proteomics approach, we had identified several putative lipid-binding proteins in the phloem exudates. Simultaneously, we identified several complex lipids as well as jasmonates. These findings prompted us to propose that phloem (phospho-) lipids could act as long-distance developmental signals in response to abiotic stress, and that they are released, sensed, and moved by phloem lipid-binding proteins (Benning et al., 2012). Indeed, the proteins we identified include lipases that could release a signaling lipid into the phloem, putative receptor components, and proteins that could mediate lipid-movement. To test this possible protein-based lipid-signaling pathway, three of the proteins, which could potentially act in a relay, are characterized here: (I) a putative GDSL-motif lipase (II) a PIG-P-like protein, with a possible receptor-like function; (III) and PLAFP (phloem lipid-associated family protein), a predicted lipid-binding protein of unknown function. Here we show that all three proteins bind lipids, in particular phosphatidic acid (PtdOH), which is known to participate in intracellular stress signaling. Genes encoding these proteins are expressed in the vasculature, a prerequisite for phloem transport. Cellular localization studies show that the proteins are not retained in the endoplasmic reticulum but surround the cell in a spotted pattern that has been previously observed with receptors and plasmodesmatal proteins. Abiotic signals that induce the production of PtdOH also regulate the expression of GDSL-lipase and PLAFP, albeit in opposite patterns. Our findings suggest that while all three proteins are indeed lipid-binding and act in the vasculature possibly in a function related to long-distance signaling, the three proteins do not act in the same but rather in distinct pathways. It also points toward PLAFP as a prime candidate to investigate long-distance lipid signaling in the plant drought response.

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Long-Distance Lipid Signaling and its Role in Plant Development and Stress Response

Cited by 18 publications

References 135 publications

An update on phloem transport: a simple bulk flow under complex regulation

An update on phloem transport: a simple bulk flow under complex regulation

Lipid remodelling: Unravelling the response to cold stress in Arabidopsis and its extremophile relative Eutrema salsugineum

Phloem Proteomics Reveals New Lipid-Binding Proteins with a Putative Role in Lipid-Mediated Signaling

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