Long distance running – Can bioprofiling predict success in endurance athletes?

König, Simone; Jockenhöfer, Charlotte; Billich, Christian; Beer, Meinrad; Machann, Jürgen; Schmidt‐Trucksäss, Arno; Schütz, Uwe

doi:10.1016/j.mehy.2020.110474

Cited by 5 publications

(8 citation statements)

References 114 publications

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“…Study showed D-mannose in type 2 diabetic rats was signi cantly increased with the risk of myocardial infarction [16] . Ultramarathon runners also been detected high levels of D-mannose in their urine [17] . Dmannose-1-phosphate easily reacts with proteins or lipids to participates in the glycosylation process and generate glycosylation end products (AGEs) [14] .…”

Section: Discussionmentioning

confidence: 99%

Effect of Acute High-Intensity Exercise on Rat Myocardium metabolic Profiles. An LC-MS Based Metabolomics Study

WANG

Cao

et al. 2022

Preprint

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Acute high-intensity exercise is a harmful manner associated with a series of myocardial injuries. Metabolism disorder of myocardium is one of the most serious conditions. However, few metabolomics-based studies provide data on the effect of exercise along with myocardial metabolism. Our study aimed to identify metabolic signatures in rat myocardium during acute high-intensity exercise and evaluate their diagnostic potential to sports injuries. SD rats were divided into control group and acute high-intensity exercise group and their myocardium samples were analyzed by LC-MS to explore metabolic alterations of rats’ myocardium. This study showed myocardium metabolism clearly differed between the two groups. there were 6 target metabolic pathways and 12 potential metabolic markers for acute high-intensity exercise. Our findings provide an insight that myocardium metabolism during acute high-intensity exercise have distinct disorders in complex lipids and fatty acids. Moreover, an increase of purine degradation products as well as signs of impaired glucose metabolism were observed. However, the amino acid was enhanced, which had a certain protective effect on the myocardium.

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Section: Discussionmentioning

confidence: 99%

Effect of Acute High-Intensity Exercise on Rat Myocardium metabolic Profiles. An LC-MS Based Metabolomics Study

WANG

Cao

et al. 2022

Preprint

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“…The capsules are safe to ingest (17.7×8.9 mm, 1.7 g) and are eliminated through the natural route in 1 to 3 days in the stool. This device is valid, reproducible, and well-tolerated [ 6 - 9 ] and does not affect the athlete’s performance. The e-Celsius capsule also has a high T° accuracy of 0.2 °C.…”

Section: Methodsmentioning

confidence: 99%

“…Unfortunately, these studies often focus on one variable or field of study [ 5 - 26 ], particularly cardiac, renal, or psychomotivational functions. Moreover, of these 23 studies, 12 (52%) protocols were conducted on a treadmill [ 5 , 13 , 19 , 27 ], on roads or nontechnical trails [ 6 , 10 , 12 , 18 , 23 , 28 ], on short distances [ 16 ], or in an extreme environment [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Study of the Kinetics of the Determinants of Performance During a Mountain Ultramarathon: Multidisciplinary Protocol of the First Trail Scientifique de Clécy 2021

Mauvieux¹,

Hingrand²,

Drigny³

et al. 2022

JMIR Res Protoc

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Background The growing interest of the scientific community in trail running has highlighted the acute effects of practice at the time of these races on isolated aspects of physiological and structural systems; biological, physiological, cognitive, and muscular functions; and the psychological state of athletes. However, no integrative study has been conducted under these conditions with so many participants and monitoring of pre-, per-, and postrace variables for up to 10 days over a distance close to 100 miles. Objective The aim of this study was to evaluate the kinetics of the performance parameters during a 156 km trail run and 6000 m of elevation gain in pre-, per-, and postrace conditions. The general hypothesis is based on significant alterations in the psychological, physiological, mechanical, biological, and cognitive parameters. Methods The Trail Scientifique de Clécy took place on November 11, 2021. This prospective experimental study provides a comprehensive exploration of the constraints and adaptations of psychophysiological and sociological variables assessed in real race conditions during a trail running of 156 km on hilly ground and 6000 m of elevation gain (D+). The study protocol allowed for repeatability of study measurements under the same experimental conditions during the race, with the race being divided into 6 identical loops of 26 km and 1000 m D+. Measurements were conducted the day before and the morning of the race, at the end of each lap, after a pit stop, and up to 10 days after the race. A total of 55 participants were included, 43 (78%) men and 12 (22%) women, who were experienced in ultra–trail-running events and with no contraindications to the practice of this sport. Results The launch of the study was authorized on October 26, 2021, under the trial number 21-0166 after a favorable opinion from the Comité de Protection des Personnes Ouest III (21.09.61/SIRIPH 2G 21.01586.000009). Of the 55 runners enrolled, 41 (75%) completed the race and 14 (25%) dropped out for various reasons, including gastric problems, hypothermia, fatigue, and musculoskeletal injuries. All the measurements for each team were completed in full. The race times (ie, excluding the measurements) ranged from 17.8206 hours for the first runner to 35.9225 hours for the last runner. The average time to complete all measurements for each lap was 64 (SD 3) minutes. Conclusions The Trail Scientifique de Clécy, by its protocol, allowed for a multidisciplinary approach to the discipline. This approach will allow for the explanation of the studied parameters in relation to each other and observation of the systems of dependence and independence. The initial results are expected in June 2022. International Registered Report Identifier (IRRID) RR1-10.2196/38027

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“…Many studies investigated the metabolic signature associated with chronic endurance exercise ( Table S3 ). Improvements in lipid metabolism were documented [ 8 , 9 , 10 , 11 , 12 , 13 , 19 , 58 , 59 ], with significant variations observed in the concentrations of 3-hydroxybutyric acid and acetoacetate (involved in ketolytic metabolism), and trimethylamine-N-oxide (utilized in phospholipid metabolism). Long-term metabolomic adaptations to chronic endurance exercise indicate an overall healthier lipid profile.…”

Section: Metabolic Signature Of Endurance Exercisementioning

confidence: 99%

“…Moreover, many of these exercise-induced changes can lead to long-term metabolic adaptations, as documented in studies on elite and professional athletes [ 1 , 8 , 9 , 10 ] as well as chronic exercise interventions [ 11 , 12 , 13 ]. In athletes, for example, years of training coupled with a unique genetic makeup result in significant metabolic adaptation specific to their type of sport: endurance training tends to increase mitochondrial content and the activity of oxidative enzymes [ 14 ], and resistance training is associated with increases in muscle fiber and increased glycolytic enzymes in skeletal muscle [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Exercise Metabolome: Insights for Health and Performance

Jaguri,

Al Thani,

Elrayess

2023

Metabolites

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Exercise has many benefits for physical and mental well-being. Metabolomics research has allowed scientists to study the impact of exercise on the body by analyzing metabolites released by tissues such as skeletal muscle, bone, and the liver. Endurance training increases mitochondrial content and oxidative enzymes, while resistance training increases muscle fiber and glycolytic enzymes. Acute endurance exercise affects amino acid metabolism, fat metabolism, cellular energy metabolism, and cofactor and vitamin metabolism. Subacute endurance exercise alters amino acid metabolism, lipid metabolism, and nucleotide metabolism. Chronic endurance exercise improves lipid metabolism and changes amino acid metabolism. Acute resistance exercise changes several metabolic pathways, including anaerobic processes and muscular strength. Chronic resistance exercise affects metabolic pathways, resulting in skeletal muscle adaptations. Combined endurance–resistance exercise alters lipid metabolism, carbohydrate metabolism, and amino acid metabolism, increasing anaerobic metabolic capacity and fatigue resistance. Studying exercise-induced metabolites is a growing field, and further research can uncover the underlying metabolic mechanisms and help tailor exercise programs for optimal health and performance.

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Long distance running – Can bioprofiling predict success in endurance athletes?

Cited by 5 publications

References 114 publications

Effect of Acute High-Intensity Exercise on Rat Myocardium metabolic Profiles. An LC-MS Based Metabolomics Study

Effect of Acute High-Intensity Exercise on Rat Myocardium metabolic Profiles. An LC-MS Based Metabolomics Study

Study of the Kinetics of the Determinants of Performance During a Mountain Ultramarathon: Multidisciplinary Protocol of the First Trail Scientifique de Clécy 2021

Exercise Metabolome: Insights for Health and Performance

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