Long-label-retaining mammary epithelial cells are created early in ductal development and distributed throughout the branching ducts

Ragle, Lauren E.; Bruno, Robert D.; Boulanger, Corinne A.; Smith, Gilbert H.

doi:10.1016/j.mod.2019.103565

Cited by 2 publications

(1 citation statement)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This does not necessarily imply that multipotent stem cells are absent in the adult gland. In a commentary, Smith and Medina [27] provide arguments for the presence of multipotent progenitors in the adult gland, and it might be premature to dismiss several studies on the presence of long-label-retaining epithelial cells and the significance of asymmetric cell division in the mammary gland, which are features of stem cells [28,29]. As part of the discussion on the developmental contributions of multipotent and unipotent stem/progenitor cells, it is correct to point out that lineage-restricted progenitors and mature cells may behave differently during normal tissue homeostasis compared to engraftment of cells into an epithelium-divested mammary fat pad [30].…”

Section: The Evolving Model Of a Mammary Epithelial Hierarchymentioning

confidence: 99%

Cellular Plasticity in Mammary Gland Development and Breast Cancer

Wicker,

Wagner

2023

Cancers

View full text Add to dashboard Cite

Cellular plasticity is a phenomenon where cells adopt different identities during development and tissue homeostasis as a response to physiological and pathological conditions. This review provides a general introduction to processes by which cells change their identity as well as the current definition of cellular plasticity in the field of mammary gland biology. Following a synopsis of the evolving model of the hierarchical development of mammary epithelial cell lineages, we discuss changes in cell identity during normal mammary gland development with particular emphasis on the effect of the gestation cycle on the emergence of new cellular states. Next, we summarize known mechanisms that promote the plasticity of epithelial lineages in the normal mammary gland and highlight the importance of the microenvironment and extracellular matrix. A discourse of cellular reprogramming during the early stages of mammary tumorigenesis that follows focuses on the origin of basal-like breast cancers from luminal progenitors and oncogenic signaling networks that orchestrate diverse developmental trajectories of transforming epithelial cells. In addition to the epithelial-to-mesenchymal transition, we highlight events of cellular reprogramming during breast cancer progression in the context of intrinsic molecular subtype switching and the genesis of the claudin-low breast cancer subtype, which represents the far end of the spectrum of epithelial cell plasticity. In the final section, we will discuss recent advances in the design of genetically engineered models to gain insight into the dynamic processes that promote cellular plasticity during mammary gland development and tumorigenesis in vivo.

show abstract