Long-lasting astrocyte reaction to persistent Junin virus infection of rat cortical neurons

Caccuri, Roberto L.; Iacono, Rubén Francisco; Weissenbacher, Mercedes; Ávila, María Mercedes; Berría, María I.

doi:10.1007/s00702-003-0010-1

Cited by 6 publications

(2 citation statements)

References 27 publications

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“…1, F and G) (31). Despite the paucity of infiltrating cells, early observations that thymectomized and nude nu/nu mice survive TCRV infection suggested a role for T cells (8,10,11) that was confirmed in this study using RAG Ϫ/Ϫ mice (Fig.…”

Section: Discussionsupporting

confidence: 69%

Immunotherapy with CpG Oligonucleotides and Antibodies to TNF-α Rescues Neonatal Mice from Lethal Arenavirus-Induced Meningoencephalitis

Pedras-Vasconcelos

Puig

Sauder

et al. 2008

The Journal of Immunology

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Viral encephalitides are life-threatening diseases in neonates partly due to the irreversible damage inflammation causes to the CNS. This study explored the role of proinflammatory cytokines in the balance between controlling viral replication and eliciting pathologic immune responses in nonlytic viral encephalitis. We show that neonatal mice challenged with arenavirus Tacaribe (TCRV) develop a meningoencephalitis characterized by high IFN-γ and TNF-α levels and mild T cell infiltration. Neutralization of the TNF-α using mAb was associated with lower chemokine expression, reduced T cell infiltration, and lower levels of IFN-γ, and TNF-α in the CNS and led to 100% survival. Moreover, treatment with Abs to TNF-α improved mobility and increased survival even after the mice developed bilateral hind limb paralysis. Of note, animals treated with anti-TNF-α Abs alone did not clear the virus despite generating Abs to TCRV. Direct activation of the innate immune response using CpG oligodeoxynucleotides in combination with anti-TNF-α Abs resulted in 100% survival and complete viral clearance. To our knowledge, this is the first demonstration of the use of innate immune modulators plus Abs to TNF-α as therapeutics for a lethal neurotropic viral infection.

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Section: Discussionsupporting

confidence: 69%

Immunotherapy with CpG Oligonucleotides and Antibodies to TNF-α Rescues Neonatal Mice from Lethal Arenavirus-Induced Meningoencephalitis

Pedras-Vasconcelos

Puig

Sauder

et al. 2008

The Journal of Immunology

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“…While the neuronal cell population is the major target for VEEV infection, it is unclear to what degree astrocytes may be involved in amplifying the virus and/or orchestrating the inflammatory response (Schoneboom et al, 2000(Schoneboom et al, , 1999. It is known, however, that reactive hyperplasia and hypertrophy of astrocytes (gliosis) may be detected in infected brains (Audouy et al, 1999;Caccuri et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Production of IL-8, IL-17, IFN-gamma and IP-10 in human astrocytes correlates with alphavirus attenuation

Peng

Borisevich

Popov

et al. 2013

Veterinary Microbiology

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Arenaviruses and Filoviruses

Raabe,

Gilchrist,

Kraft

2023

ClinMicroNow

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This chapter focuses on the viruses capable of causing viral hemorrhagic fever (VHF) from two taxa, the families Arenaviridae and Filoviridae . Some members of these virus families can cause severe VHF with high mortality in localized areas of the world. Continuing detection and isolation of new arenavirus and filovirus species from new geographic locations remains important for public health. Human infection with filoviruses and arenaviruses can cause a wide spectrum of illness. For virus isolation, antigen detection, and RT‐PCR, serum, heparinized plasma, or whole blood should be collected during the acute, febrile stages of illness and frozen on dry ice or in liquid nitrogen vapor. Most arenavirus and filovirus species grow well in cell culture. Early diagnosis of arenavirus and filovirus infections is desirable since specific monoclonal antibody treatments and appropriately selected antiviral drugs are, in certain cases, effective when treatment is initiated soon after onset.

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Long-lasting astrocyte reaction to persistent Junin virus infection of rat cortical neurons

Cited by 6 publications

References 27 publications

Immunotherapy with CpG Oligonucleotides and Antibodies to TNF-α Rescues Neonatal Mice from Lethal Arenavirus-Induced Meningoencephalitis

Immunotherapy with CpG Oligonucleotides and Antibodies to TNF-α Rescues Neonatal Mice from Lethal Arenavirus-Induced Meningoencephalitis

Production of IL-8, IL-17, IFN-gamma and IP-10 in human astrocytes correlates with alphavirus attenuation

Arenaviruses and Filoviruses

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