2002
DOI: 10.1080/000155502320323270
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Long-lasting "Christmas Tree Rash" in an Adolescent: Isotopic Response of Indeterminate Cell Histiocytosis in Pityriasis Rosea?

Abstract: A 13-year-old girl developed a non-pruritic pityriasis rosea-like rash, which did not respond to topical corticosteroids or UV therapy but persisted for 2 years. The lymphohistiocytic infiltrate in the upper dermis showed mononuclear cells immunoreactive with S100, CD68, factor XIIIa and CD1a. Electron microscopic evaluation of these cells demonstrated lamellated dense bodies but no Birbeck granules, lipid vacuoles or cholesterol crystals. Two diagnoses were made: a primarily clinical diagnosis of generalized … Show more

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Cited by 40 publications
(44 citation statements)
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“…Most skin lesions occur spontaneously; however, triggering factors have been identified in some cases, such as scabies 3 and pityriasis rosea. 4 Spontaneous resolution of the lesions has also been reported. 5 No triggering factors were revealed in our patient.…”
Section: Recurrent Generalized Indeterminate Cell Histiocytosis: a Camentioning
confidence: 93%
“…Most skin lesions occur spontaneously; however, triggering factors have been identified in some cases, such as scabies 3 and pityriasis rosea. 4 Spontaneous resolution of the lesions has also been reported. 5 No triggering factors were revealed in our patient.…”
Section: Recurrent Generalized Indeterminate Cell Histiocytosis: a Camentioning
confidence: 93%
“…Two clinical subtypes seem to predominate: a solitary nodular form [11][12][13][14]16 (Fig 1, A) and a multiple papulonodular form 3,5,6,[8][9][10]15,[17][18][19][20][21][22][23][24][25][26] (Fig 1, B). The former is usually characterized by a single, soft red asymptomatic nodule about 1 cm in diameter; the latter presents with a widespread eruption of multiple, firm asymptomatic lesions ranging in size from a few millimeters to 1 cm, varying in color from dark red to brownish and covered by intact skin.…”
Section: Clinical Findingsmentioning
confidence: 99%
“…7 Age of onset and incidence ICH affects predominantly adults, showing no sex-or age-specific predilection, although about one third of the cases so far reported in the literature are pediatric. 4,[8][9][10][11][12][13][14][15] Since the original description of Wood et al, 5 only about 20 cases of ICH had been reported, until a recent study on a large collection that included 18 patients with ICH. 4 …”
mentioning
confidence: 99%
“…The postherpetic isotopic reactions reported to date include granulomatous reactions of various types (majority), malignant tumours, leukaemic or lymphomatous infiltrations, infections, dysimmune reactions, and comedonic-microcystic reactions [12,15,17] (Fig. 4).…”
Section: Lines Of Blaschkomentioning
confidence: 99%
“…Cutaneous areas that have been infected by herpes viruses (mainly varicella zoster virus) are known to be privileged sites for either selectively harbouring skin diseases (malignancies, infections, immune dysregulation) not appearing elsewhere (locus minoris resistentiae, lmr) or selectively rejecting skin diseases involving the rest of the body (locus majoris resistentiae, LMR) [11,12,13,14,15,17] (Fig. 4).…”
Section: Lines Of Blaschkomentioning
confidence: 99%